AUTHOR=Ng Thomas S. C. , Gao Xin , Salari Keyan , Zlatev Dimitar V. , Heidari Pedram , Kamran Sophia C. 

TITLE=Incorporating PSMA-Targeting Theranostics Into Personalized Prostate Cancer Treatment: a Multidisciplinary Perspective

JOURNAL=Frontiers in Oncology

VOLUME=Volume 11 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.722277

DOI=10.3389/fonc.2021.722277

ISSN=2234-943X

ABSTRACT=Recent developments in prostate-specific membrane antigen (PSMA) targeted imaging and therapeutics (theranostics) promise to revolutionize the management of primary, biochemically recurrent, and metastatic prostate cancer. In order to maximize the clinical impact of PSMA-targeted theranostics, a coordinated approach between the clinical stakeholders involved in prostate cancer management is required. Here, we present a vision for multidisciplinary use of PSMA theranostics from the viewpoints of nuclear radiology, medical oncology/urology and radiation oncology. We review the state-of-the-art PSMA-based imaging and therapeutics available and upcoming in the clinical pipeline and examine current and potential impacts on prostate cancer management from early localized disease to advanced treatment-refractory disease. Finally, we highlight the clinical and research opportunities related to PSMA-targeted theranostics and describe the importance of multidisciplinary collaboration in this space.