AUTHOR=Zhang Zheng , Zhao Shuangshuang , Yang Haizhen , Chen Yanwei , Feng Huahui , An Maohui , Chen Baoding 

TITLE=Prognostic and Immunological Role of Gasdermin E in Pan-Cancer Analysis

JOURNAL=Frontiers in Oncology

VOLUME=Volume 11 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.706266

DOI=10.3389/fonc.2021.706266

ISSN=2234-943X

ABSTRACT=Although accumulating cell- or animal-based experiments provide the relationship between Gasdermin E (GSDME) and human diseases, especially malignant cancers, no pan-cancer analysis about the function of GSMDE in cancer management can be available. Our research, for the first time, explored the potential carcinogenic role of GSDME across thirty-three tumors from the public platform of TCGA (The cancer genome atlas) database. GSDME is highly expressed in most malignant cancers, and obvious relationship exist between GSDME level and survival prognosis of cancer patients. The expression of GSDME was statically associated with the cancer-associated fibroblast infiltration in diverse cancer types, such as BLCA, CHOL, GBM, KIRC, LIHC, MESO, STAD and UCEC. Furthermore, pyroptosis, sensory perception of sound and defense response to bacterium associated functions were involved in the functional mechanisms of GSDME based on GO analysis. Our first pan-cancer analysis of GSDME not only broadens understanding of the carcinogenic roles of GSDME, but also provides a promising therapeutic strategy for benefiting an increasing number of cancerous patients based on GSDME-induced pyroptosis.