AUTHOR=Pappalardo Annalisa , Giunta Emilio Francesco , Tirino Giuseppe , Pompella Luca , Federico Piera , Daniele Bruno , De Vita Ferdinando , Petrillo Angelica 

TITLE=Adjuvant Treatment in Pancreatic Cancer: Shaping the Future of the Curative Setting

JOURNAL=Frontiers in Oncology

VOLUME=Volume 11 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.695627

DOI=10.3389/fonc.2021.695627

ISSN=2234-943X

ABSTRACT=Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease even in the early stages, despite surgical and pharmacological progresses in the latest years. High potential for metastasis is the main cause of therapeutic failure in localized disease, highlighting the current limited knowledge of underneath pathological processes. However, nowadays the research is focusing on the search of personalized approach also in the adjuvant setting for PDAC, by implementing the use of biomarkers and investigating new therapeutic targets. In this context, the aim of this narrative review is to summarize the current treatment scenario and new potential therapeutic approaches in early stage PDAC, from both preclinical and clinical point of view. Additionally, the review examines the role of targeted therapies in localized PDAC and the influence of neoadjuvant treatments on survival outcomes.