AUTHOR=Javed Zeeshan , Javed Iqbal Muhammad , Rasheed Amna , Sadia Haleema , Raza Shahid , Irshad Asma , Koch Wojciech , Kukula-Koch Wirginia , Głowniak-Lipa Anna , Cho William C. , Sharifi-Rad Javad 

TITLE=Regulation of Hedgehog Signaling by miRNAs and Nanoformulations: A Possible Therapeutic Solution for Colorectal Cancer

JOURNAL=Frontiers in Oncology

VOLUME=Volume 10 - 2020

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.607607

DOI=10.3389/fonc.2020.607607

ISSN=2234-943X

ABSTRACT=Hedgehog (Hh) signaling aberrations trigger differentiation and proliferation in colorectal cancer (CRC). The current approaches to inhibit this vital cellular pathway involve small molecule inhibitors which provoke some serious side effects.. Therefore, it is necessary to look for new therapeutic options. MicroRNAs (miRNAs) are small molecules that modulate expression of different genes and can be utilized as a potential therapeutic option for CRC. Nanoformulations have been implemented in the treatment of plethora of diseases. Owing to their limited cytotoxicity, excessive bioavailability and high specificity nanoparticles  NPs can be used as an alternative drug delivery platform for the Hh signaling mediated colorectal cancer. This article reviews the hedgehog signaling and its involvement in CRC with focus on miRNAs and nanoformulations as possible diagnostic/prognostic and therapeutics for the CRC.