AUTHOR=Wei Yunxiong , Cao Yaqing , Sun Rui , Cheng Lin , Xiong Xia , Jin Xin , He Xiaoyuan , Lu Wenyi , Zhao Mingfeng 

TITLE=Targeting Bcl-2 Proteins in Acute Myeloid Leukemia

JOURNAL=Frontiers in Oncology

VOLUME=Volume 10 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.584974

DOI=10.3389/fonc.2020.584974

ISSN=2234-943X

ABSTRACT=B-cell lymphoma 2 (BCL-2) family proteins play an important role in intrinsic apoptosis.
Overexpression of BCL-2 proteins in acute myeloid leukemia can circumvent apoptotic and
chemotherapy resistance. Within this background, exploration in antiapoptotic BCL-2 inhibitors
were considered to be a tremendous potential toward the discovery of novel pharmacological
modulators in cancer. This review outlines the impact of the BCL-2 family proteins on intrinsic
apoptosis and the development in AML. Furthermore, we will also review the new combination
with venetoclax to overcome resistance to venetoclax and the biomarkers of response identified
from the early phase clinical trials performed.