AUTHOR=van der Kemp Wybe J. M. , Stehouwer Bertine L. , Runge Jurgen H. , Wijnen Jannie P. , Nederveen Aart J. , Luijten Peter R. , Klomp Dennis W. J. 

TITLE=Glycerophosphocholine and Glycerophosphoethanolamine Are Not the Main Sources of the In Vivo31P MRS Phosphodiester Signals from Healthy Fibroglandular Breast Tissue at 7 T

JOURNAL=Frontiers in Oncology

VOLUME=Volume 6 - 2016

YEAR=2016

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2016.00029

DOI=10.3389/fonc.2016.00029

ISSN=2234-943X

ABSTRACT=Purpose: The identification of the phosphodiester <sup>31</sup>P MR signals in the healthy human breast at ultra-high field.

Methods:<i>In vivo</i> <sup>31</sup>P MRS measurements at 7 tesla of the phosphodiester signals in the breast were performed investigating the chemical shifts, the transverse- and the longitudinal relaxation times. Chemical shifts and transverse relaxation times were compared with non-ambiguous phosphodiester signals from the liver.

Results: The chemical shifts of the phosphodiester signals are shifted -0.5 ppm with respect to glycerophosphocholine and -ethanolamine, and the transverse and longitudinal relaxation times for these signals are a factor 3 to 4 shorter than expected for aqueous glycerophosphocholine and -ethanolamine.

Conclusions: The available experimental evidence suggests that glycerophosphocholine and –ethanolamine are not the main source of the phosphodiester signals measured in fibroglandular breast tissue at 7 tesla. These signals may predominantly originate from mobile phospholipids.