AUTHOR=De Veirman Kim , Van Valckenborgh Els , Lahmar Qods , Geeraerts Xenia , De Bruyne Elke , Menu Eline , Van Riet Ivan , Vanderkerken Karin , Van Ginderachter Jo A. 

TITLE=Myeloid-Derived Suppressor Cells as Therapeutic Target in Hematological Malignancies

JOURNAL=Frontiers in Oncology

VOLUME=Volume 4 - 2014

YEAR=2014

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2014.00349

DOI=10.3389/fonc.2014.00349

ISSN=2234-943X

ABSTRACT=Myeloid derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells that accumulate during pathological conditions such as cancer and are associated with a poor clinical outcome. MDSC expansion hampers the host anti-tumor immune response by inhibition of T cell proliferation, cytokine secretion and recruitment of regulatory T cells. In addition, MDSC exert non-immunological functions including the promotion of angiogenesis, tumor invasion and metastasis. Recent years, MDSC are considered as a potential target in solid tumors and hematological malignancies to enhance the effects of currently used immune modulating agents. This review focuses on the characteristics, distribution, functions, cell-cell interactions and targeting of MDSC in hematological malignancies including multiple myeloma, lymphoma and leukemia.