AUTHOR=González-Rodríguez Yaiza , La Nuez-García Manuel A. , Jiménez Marina , Villar-Suárez Vega , Casado-Santos Alejandro 
  
TITLE=Comparative effects of MKARE® eggshell membrane and hydrolyzed collagen as nutricosmetics on skin biophysical properties: a randomized clinical trial
  
JOURNAL=Frontiers in Nutrition
  
VOLUME=Volume 12 - 2025
  
YEAR=2026
  
URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1689701
  
DOI=10.3389/fnut.2025.1689701
  
ISSN=2296-861X
  
ABSTRACT=IntroductionThis study aimed to investigate the impact of fresh eggshell membrane (MKARE®) as a nutricosmetic ingredient, with a focus on its influence on skin properties. Biomechanical measurement devices were used to assess the effects on skin condition, and the results were compared with hydrolyzed collagen and a placebo.MethodsBiophysical parameters were analyzed (using Cutometer®, Tewameter®, Corneometer®, and VISIA®) among participants showing signs of aging. These individuals consumed either 300 mg of fresh eggshell membrane (MKARE®) or 8,000 mg of hydrolyzed collagen, and the results were compared to a placebo group after 28 and 57 days.ResultsThe results showed significant improvements in skin firmness/flexibility and elasticity after 57 days of MKARE® intake, compared to both the hydrolyzed collagen and placebo groups.ConclusionThis study demonstrates that a 300 mg intake of fresh membrane MKARE® positively affects mechanical skin parameters compared to the group that consumed 8,000 mg of hydrolyzed collagen or the placebo group. These improvements suggest that MKARE® consumption regenerates the skin structure, primarily due to positive changes in collagen and elastin formation, which are key contributors to the improvement of skin firmness, elasticity, and barrier protection.