AUTHOR=Liu TingTing , Wang LiMing , Ou LingLing , Feng Jing , Cheng JiaLi , Gong ZhaoLong 

TITLE=Impact of whole-grain interventions on serum vitamin D levels in individuals at risk of diabetes

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1658961

DOI=10.3389/fnut.2025.1658961

ISSN=2296-861X

ABSTRACT=IntroductionWe examined the effects of a whole-grain intervention on serum vitamin D levels in pre-diabetic individuals in China.MethodsParticipants aged 18–65 years at risk of diabetes participated in a 12-week randomised parallel controlled trial. Intervention groups consumed 50 g/day and 100 g/day of whole grains, whereas the control group maintained a regular diet. All participants received nutritional guidance. Serum 25-hydroxyvitamin D levels were monitored at baseline, 6 weeks, and 12 weeks using liquid chromatography–tandem mass spectrometry.ResultsAt 6 weeks, serum 25-hydroxyvitamin D levels remained insufficient across all groups. By 12 weeks, both intervention groups showed significant increases, reaching adequate levels, whereas the control group remained at the lower limit of adequacy.ConclusionSustained whole-grain intake improves vitamin D status in pre-diabetic individuals.