AUTHOR=Zhou Yuan-Feng , Zhang Xiang-Tao , Zeng Qing-Tian , He Hua-Bin 

TITLE=The association of the atherogenic index of plasma with hypertension, diabetes, and their comorbidities in Chinese middle-aged and elderly people: a cross-sectional study from CHARLS

JOURNAL=Frontiers in Nutrition

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1607601

DOI=10.3389/fnut.2025.1607601

ISSN=2296-861X

ABSTRACT=BackgroundThe atherogenic index of plasma (AIP) is acknowledged as a contemporary indicator of insulin resistance. Previous research on AIP and metabolism-related diseases was limited and primarily concentrated on individual diseases. The aim of this investigation was to systematically examine the relationship among AIP and hypertension, diabetes, and their comorbidities.MethodsThis study employed a cross-sectional design. Using data from the China Health and Retirement Longitudinal Study (CHARLS) of 2011, we conducted a systematic investigation of the association between AIP and the risk of hypertension, diabetes, and their comorbidities through restricted cubic spline plots (RCS) and multiple multivariate logistic regression. Additionally, receiver operating characteristic curves (ROC) were employed to assess AIP’s predictive validity for these conditions.ResultsThis study comprised 8,450 participants, with an average age of 59.57 years. The prevalence of hypertension, diabetes, and their comorbidities were 40.98, 15.62, and 8.52%, respectively. The RCS demonstrated a non-linear positive correlation between the AIP and these disorders. For each unit increased in AIP, the risk of hypertension, diabetes, and comorbidities elevated by 0.63-fold, 2.55-fold, and 2.75-fold, respectively. The ROC analysis demonstrated that AIP outperformed traditional lipid parameters in predicting both diabetes and comorbidities risk (AUC: 0.6465, 0.6725).ConclusionThis study demonstrated that heightened AIP was strongly linked to a high risk of hypertension, diabetes, and comorbidities among middle-aged and elderly Chinese individuals.