AUTHOR=Zhang-Yin J. , Panagiotidis Emmanouil 

TITLE=Case Report: 18F-Fluorocholine PET/CT for detecting brown tumours in patients with hyperparathyroidism: a short case series and literature review

JOURNAL=Frontiers in Nuclear Medicine

VOLUME=Volume 5 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/nuclear-medicine/articles/10.3389/fnume.2025.1693642

DOI=10.3389/fnume.2025.1693642

ISSN=2673-8880

ABSTRACT=IntroductionBrown tumours (BTs), also known as osteitis fibrosa cystica, are benign osteolytic lesions associated with hyperparathyroidism (HPT). BTs are cured by correcting the hypercalcaemia and HPT, which often requires surgical resection of the parathyroid adenoma. 1⁸F-fluorocholine (FCH) PET/CT is becoming an effective tool for detecting parathyroid adenomas in cases of hyperparathyroidism. This study aims to evaluate the role of FCH PET/CT in detecting brown tumours in patients with hyperparathyroidism.Clinical casesThree cases are presented to demonstrate the effectiveness of FCH PET/CT in detecting BTs in patients presenting with clinical and biochemical signs of HPT with suspicion of BTs.Literature reviewA literature review aimed to summarize the bibliographic evidence on the use of this technique in this setting, which is relatively innovative.ConclusionFCH PET/CT appears to be a useful tool for detecting BTs, and further prospective studies are needed to confirm this.