Front. Neurosci. Frontiers in Neuroscience Front. Neurosci. 1662-453X Frontiers Media S.A. 10.3389/fnins.2025.1752611 Correction Correction: Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer's disease Xu Wenxiu 1 † Ren Beida 2 3 † Zhang Zehan 1 Chen Congai 2 Xu Tian 1 Liu Shuling 1 Ma Chongyang 4 Wang Xueqian 1 * Wang Qingguo 1 * Cheng Fafeng 1 * School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China School of Traditional Chinese Medicine, Capital Medical University, Beijing, China Correspondence: Xueqian Wang, shirlyding@163.com; Qingguo Wang, wangqg8558@163.com; Fafeng Cheng, fafengcheng@gmail.com

These authors have contributed equally to this work and share first authorship

 04 12 2025 2025 19 1752611 23 11 2025 25 11 2025 Copyright © 2025 Xu, Ren, Zhang, Chen, Xu, Liu, Ma, Wang, Wang and Cheng. 2025 Xu, Ren, Zhang, Chen, Xu, Liu, Ma, Wang, Wang and Cheng https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. A Correction on Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer's disease by Xu, W., Ren, B., Zhang, Z., Chen, C., Xu, T., Liu, S., Ma, C., Wang, X., Wang, Q., and Cheng, F. (2022). Front. Neurosci. 16:943400. doi: 10.3389/fnins.2022.943400 Alzheimer's disease Qin-Zhi-Zhu-Dan Formula TNF signaling pathway network pharmacology inflammatory response section-at-acceptance Neurodegeneration

There was a mistake in Figure 10B as published. The higher magnification images in the QZZD and DNZ columns were incorrectly swapped: the image labeled QZZD belonged to the DNZ group, and the image labeled DNZ belonged to the QZZD group. The corrected Figure 10 appears below.

Effects of QZZD on neuronal death. (A) CA1 region of the hippocampus after HE staining [Scale bar: 75 and 25 μm (insert), n = 6]. (B) CA1 region of the hippocampus after NeuN staining [Scale bar: 75 and 25 μm (insert)]. (C) Number of NeuN-positive cells in CA1 region of the hippocampus. Values were expressed as means ± SD, n = 6 in each group. **p < 0.01, compared with the control group; ##p < 0.01, compared with the model group.

Panel A displays a Western blot showing protein expressions for β-Amyloid, IL-6, NF-κBp65, TNF Receptor 1, p-ERK 1/2, ERK 1/2, and β-actin across different groups (Control, Model, QZZD, DNZ). Panel B contains bar graphs comparing protein expression levels, showing variations among the groups. Panel C shows microscopic images of tissue sections stained for Aβ, TNFR1, NF-κBp65, and IL-6 across the same groups. Panel D includes bar graphs quantifying staining intensity for the proteins.

There was a mistake in Figure 11C as published. An image designated for the QZZD group was incorrectly reused in both QZZD and DNZ panels. The corrected Figure 11 appears below.

Effects of QZZD on expressions of Aβ, IL-6, NF-κBp65, TNFR1, p-ERK1/2 and ERK1/2 in hippocampal tissues of APP/PS1 double transgenic mice with dementia. (A) Western blotting analysis showing the protein expression levels of Aβ, IL-6, NF-κBp65, TNFR1, p-ERK1/2 and ERK1/2 in the hippocampus. (B) Quantitative analysis of Aβ, IL-6, NF-κBp65, TNFR1, p-ERK1/2, and ERK1/2 protein bands. Values are expressed as the mean ± SD, n = 6 in each group. **p < 0.01, compared with the control group; #p < 0.05, ##p < 0.01, compared with the model group. (C) Immunohistochemistry analysis showing the protein expression levels of Aβ, TNFR1, NF-κBp65, and IL-6 in the hippocampus. (D) The average optical density of Aβ, TNFR1, NF-κBp65 and IL-6 in the hippocampus. Values are expressed as the mean ± SD, n = 6 for each group. **p < 0.01, compared with the control group; #p < 0.05, ##p < 0.01, compared with the model group.

Histological and fluorescent images of brain tissue in control, model, QZZD, and DNZ groups are shown. Panel A displays stained tissue at two magnifications, indicating structural differences. Black arrows highlight specific features. Panel B shows fluorescent images, highlighting cellular differences under specific staining. Panel C is a bar chart illustrating relative expression levels, with statistical significance indicated by asterisks. Scale bars are present in panels A and B.

The original version of this article has been updated.

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Edited and reviewed by: Maria A. Tikhonova, Scientific Research Institute of Neurosciences and Medicine, Russia