Front. Neurosci. Frontiers in Neuroscience Front. Neurosci. 1662-453X Frontiers Media S.A. 10.3389/fnins.2025.1662162 Neuroscience Correction Correction: Nicotine-mediated effects in neuronal and mouse models of synucleinopathy Fares Mohamed Bilal 1 † Alijevic Omar 1 Johne Stephanie 1 Overk Cassia 2 Hashimoto Makoto 2 † Kondylis Athanasios 1 Adame Anthony 2 Dulize Remi 1 Peric Dariusz 1 Nury Catherine 1 Battey James 1 Guedj Emmanuel 1 Sierro Nicolas 1 Mc Hugh Damian 1 Rockenstein Edward 2 Kim Changyoun 2 † Rissman Robert A. 2 Hoeng Julia 1 Peitsch Manuel C. 1 Masliah Eliezer 2 † Mathis Carole 1 * 1PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland 2Department of Neurosciences, University of California, San Diego, San Diego, CA, United States

Edited and reviewed by: Guo-Yuan Yang, Shanghai Jiao Tong University, China

 *Correspondence: Carole Mathis carole.mathis@pmi.com

†Present addresses: Mohamed Bilal Fares, ND Biosciences, Biopole, Épalinges, Switzerland

Makoto Hashimoto, Laboratory for Parkinson's Disease, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

Changyoun Kim and Eliezer Masliah, Laboratory of Neurogenetics, National Institute on Aging, National Institute of Health, Bethesda, MD, United States

 01 08 2025 2025 19 1662162 08 07 2025 15 07 2025 Copyright © 2025 Fares, Alijevic, Johne, Overk, Hashimoto, Kondylis, Adame, Dulize, Peric, Nury, Battey, Guedj, Sierro, Mc Hugh, Rockenstein, Kim, Rissman, Hoeng, Peitsch, Masliah and Mathis. 2025 Fares, Alijevic, Johne, Overk, Hashimoto, Kondylis, Adame, Dulize, Peric, Nury, Battey, Guedj, Sierro, Mc Hugh, Rockenstein, Kim, Rissman, Hoeng, Peitsch, Masliah and Mathis

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 A Correction on Nicotine-mediated effects in neuronal and mouse models of synucleinopathy by Fares, M. B., Alijevic, O., Johne, S., Overk, C., Hashimoto, M., Kondylis, A., Adame, A., Dulize, R., Peric, D., Nury, C., Battey, J., Guedj, E., Sierro, N., Mc Hugh, D., Rockenstein, E., Kim, C., Rissman, R. A., Hoeng, J., Peitsch, M. C., Masliah, E., and Mathis, C. (2023). Front. Neurosci. 17:1239009. doi: 10.3389/fnins.2023.1239009 synucleinopathy induced pluripotent stem cell (iPSC) transgenic mice nicotine nicotinic acetylcholine receptors (nAChR) neuroprotection section-at-acceptance Neurodegeneration

In the published article, there was an error in Figure 3C as published whereby micro-repeats appeared in the panel corresponding to the hippocampus of the vehicle non-tg control image. The corrected Figure 3 and its caption appear below.

Effects of nicotine treatment on neurodegeneration and locomotor activity in α-Syn tg mice. Twelve-month-old PDGFβ α-Syn-tg and non-tg mice were treated with nicotine (0.1 mg/kg intraperitoneal [IP]) or saline (= vehicle) twice daily for 2 weeks. Brain sections were immunohistochemically evaluated for neurodegeneration with the neuronal marker NeuN (A, B) and the dopaminergic marker anti-TH (C, D). (A) Representative photomicrographs and (B) quantitation of the number of neurons in the neocortex, hippocampus, and striatum. While the number of NeuN-positive cells was unchanged in the neocortex and striatum, saline-treated α-Syn tg mice had significantly fewer neurons in the hippocampus than saline-treated non-tg mice. Nicotine treatment normalized the number of NeuN-positive cells in the hippocampus of α-Syn tg mice relative to saline-treated α-Syn tg mice. N = 8/group. Scale bar = 50 μm.*p < 0.0001, #p < 0.001. (C) Representative photomicrographs and (D) quantitation of TH immunoreactivity in the substantia nigra (s. nigra), hippocampus, and striatum. While TH immunoreactivity was unchanged in the hippocampus and substantia nigra, saline-treated α-Syn tg mice exhibited significantly less immunoreactivity in the striatum than saline-treated non-tg mice. Nicotine treatment normalized TH immunoreactivity in the striatum of α-Syn tg mice relative to saline-treated α-Syn tg mice. N = 8/group. Scale bar = 50 μm. *p < 0.05, #p < 0.01. (E) The effect of nicotine treatment on locomotor activity was assessed using the rotarod test. Saline-treated α-Syn tg mice spent significantly less time on the rotarod than saline-treated non-tg mice. Nicotine-treated α-Syn tg mice remained on the rotarod for significantly longer than saline-treated α-Syn tg mice *p < 0.05, N = 8 mice/group. In panels (B, D), dots represent individual values and bars denote the mean ± standard error of the mean.

The original article has been updated.

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