AUTHOR=Li Ning , Wang Lijing , Xu Xiaoying , Hu Yadong , Chen Yajing , Jiang Ye 

TITLE=Development and validation of a predictive nomogram for cerebral white matter hyperintensities: insights from a comprehensive clinical and laboratory analysis

JOURNAL=Frontiers in Neuroscience

VOLUME=Volume 19 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1642057

DOI=10.3389/fnins.2025.1642057

ISSN=1662-453X

ABSTRACT=BackgroundWhite matter hyperintensities (WMH) are key imaging markers of cerebral small vessel disease (CSVD), associated with cognitive decline and stroke risk. An accurate predictive model is needed for early risk assessment.MethodsThis retrospective study utilized data from 587 patients undergoing cranial magnetic resonance imaging (MRI) at Hebei University’s Neurology Department. A predictive model for WMH was developed using a combination of clinical and laboratory parameters through Least Absolute Shrinkage and Selection Operator (LASSO) regression and binary logistic regression analysis. The model’s performance was evaluated using area under the receiver operating characteristic curve (AUC-ROC), calibration plots, and decision curve analysis (DCA).ResultsKey predictors included age, history of stroke, hypertension, triiodothyronine levels, albumin- globulin ratio, and homocysteine. The nomogram achieved an AUC of 0.783 (95% CI: 0.738–0.829) in the training cohort and 0.762 (95% CI: 0.690–0.834) in the validation cohort. Calibration and DCA confirmed the model’s clinical applicability.ConclusionThis study presents a validated nomogram for predicting WMH, integrating clinical and biochemical markers. The model demonstrated robust predictive accuracy and potential for early risk stratification. Future studies should focus on multi-center validation and expanded risk factor inclusion.