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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Neurosci.</journal-id>
<journal-title>Frontiers in Neuroscience</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Neurosci.</abbrev-journal-title>
<issn pub-type="epub">1662-453X</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fnins.2022.854471</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Neuroscience</subject>
<subj-group>
<subject>Editorial</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Editorial: From Raw MEG/EEG to Publication: How to Perform MEG/EEG Group Analysis With Free Academic Software</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Delorme</surname> <given-names>Arnaud</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x0002A;</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/10138/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Oostenveld</surname> <given-names>Robert</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/2597/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Tadel</surname> <given-names>Francois</given-names></name>
<xref ref-type="aff" rid="aff5"><sup>5</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Gramfort</surname> <given-names>Alexandre</given-names></name>
<xref ref-type="aff" rid="aff6"><sup>6</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/14532/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Nagarajan</surname> <given-names>Srikantan</given-names></name>
<xref ref-type="aff" rid="aff7"><sup>7</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/316/overview"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Litvak</surname> <given-names>Vladimir</given-names></name>
<xref ref-type="aff" rid="aff8"><sup>8</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/62378/overview"/>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup><institution>CerCo, CNRS, Paul Sabatier University</institution>, <addr-line>Toulouse</addr-line>, <country>France</country></aff>
<aff id="aff2"><sup>2</sup><institution>Swartz Center for Computational Neurosciences, Institute of Neural Computation, University of California, San Diego</institution>, <addr-line>San Diego, CA</addr-line>, <country>United States</country></aff>
<aff id="aff3"><sup>3</sup><institution>Donders Institute for Brain, Cognition, and Behaviour, Radboud University</institution>, <addr-line>Nijmegen</addr-line>, <country>Netherlands</country></aff>
<aff id="aff4"><sup>4</sup><institution>NatMEG, Karolinska Institutet</institution>, <addr-line>Stockholm</addr-line>, <country>Sweden</country></aff>
<aff id="aff5"><sup>5</sup><institution>Signal and Image Processing Institute, University of Southern California</institution>, <addr-line>Los Angeles, CA</addr-line>, <country>United States</country></aff>
<aff id="aff6"><sup>6</sup><institution>Universit&#x000E9; Paris-Saclay, Inria, CEA</institution>, <addr-line>Palaiseau</addr-line>, <country>France</country></aff>
<aff id="aff7"><sup>7</sup><institution>Department of Radiology and Biomedical Imaging, University of California, San Francisco</institution>, <addr-line>San Francisco, CA</addr-line>, <country>United States</country></aff>
<aff id="aff8"><sup>8</sup><institution>Welcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology</institution>, <addr-line>London</addr-line>, <country>United Kingdom</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited and reviewed by: Vince D. Calhoun, Georgia State University, United States</p></fn>
<corresp id="c001">&#x0002A;Correspondence: Arnaud Delorme <email>arnodelorme&#x00040;gmail.com</email></corresp>
<fn fn-type="other" id="fn001"><p>This article was submitted to Brain Imaging Methods, a section of the journal Frontiers in Neuroscience</p></fn></author-notes>
<pub-date pub-type="epub">
<day>13</day>
<month>04</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="collection">
<year>2022</year>
</pub-date>
<volume>16</volume>
<elocation-id>854471</elocation-id>
<history>
<date date-type="received">
<day>14</day>
<month>01</month>
<year>2022</year>
</date>
<date date-type="accepted">
<day>25</day>
<month>02</month>
<year>2022</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x000A9; 2022 Delorme, Oostenveld, Tadel, Gramfort, Nagarajan and Litvak.</copyright-statement>
<copyright-year>2022</copyright-year>
<copyright-holder>Delorme, Oostenveld, Tadel, Gramfort, Nagarajan and Litvak</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<related-article id="RA1" related-article-type="commentary-article" xlink:href="https://www.frontiersin.org/research-topics/5158/from-raw-megeeg-to-publication-how-to-perform-megeeg-group-analysis-with-free-academic-software" ext-link-type="uri">Editorial of the Research Topic <article-title>From Raw MEG/EEG to Publication: How to Perform MEG/EEG Group Analysis With Free Academic Software</article-title></related-article>
<kwd-group>
<kwd>EEG</kwd>
<kwd>MEG</kwd>
<kwd>iEEG</kwd>
<kwd>BIDS</kwd>
<kwd>pipeline</kwd>
</kwd-group>
<counts>
<fig-count count="0"/>
<table-count count="1"/>
<equation-count count="0"/>
<ref-count count="5"/>
<page-count count="4"/>
<word-count count="2195"/>
</counts>
</article-meta>
</front>
<body>
<p>Free and open-source academic toolboxes have gained increasing prominence in the field of MEG/EEG research to disseminate cutting-edge methods, share best practices between different research groups, and pool resources for developing essential tools for the MEG/EEG community. Large and vibrant research communities have emerged around several of these toolboxes in recent years. Training events are regularly held around the world where the basics of each toolbox are explained by its respective developers and experienced power users. However, most training material and tutorials only show analysis of a single &#x0201C;typical best&#x0201D; subject, whereas most real MEG/EEG studies involve group data analysis. It is then left to the researchers to figure out how to make the transition and obtain group results. This special Research Topic addresses this gap by publishing detailed descriptions of complete group analyses for which code and data are also shared. The level of detail of the description should be such that the readers will be able to fully reproduce the analysis and results and port the analysis to their own data.</p>
<p>A total of 25 articles, summarized in <xref ref-type="table" rid="T1">Table 1</xref>, were accepted for this special issue. In particular to foster comparable analysis with different tools and strategies, we encouraged authors to reuse a dataset containing responses to face stimuli acquired by Richard Henson and Daniel Wakeman (Wakeman and Henson, <xref ref-type="bibr" rid="B5">2015</xref>; <ext-link ext-link-type="uri" xlink:href="https://openfmri.org/dataset/ds000117/">https://openfmri.org/dataset/ds000117/</ext-link>) (HW dataset). This dataset is formatted following the Brain Imaging Data Structure specification (Gorgolewski et al., <xref ref-type="bibr" rid="B1">2016</xref>), which has become increasingly popular in the MEG (Niso et al., <xref ref-type="bibr" rid="B3">2018</xref>), EEG (Pernet et al., <xref ref-type="bibr" rid="B4">2019</xref>) and iEEG fields (Holdgraf et al., <xref ref-type="bibr" rid="B2">2019</xref>). The specific dataset contains multiple modalities, including EEG (with digitized electrode positions), MEG, fMRI, and anatomical MRI, making it suitable for demonstrating multimodal analysis pipelines. Out of the 25 published articles, 10 are using this data (<xref ref-type="table" rid="T1">Table 1</xref>). All other articles used data that is also publicly available.</p>
<table-wrap position="float" id="T1">
<label>Table 1</label>
<caption><p>Article part of the special issue by order of publication date.</p></caption>
<table frame="hsides" rules="groups">
<thead><tr>
<th valign="top" align="left"><bold>Title</bold></th>
<th valign="top" align="left"><bold>Authors</bold></th>
<th valign="top" align="left"><bold>Script location</bold></th>
<th valign="top" align="left"><bold>License</bold></th>
<th valign="top" align="left"><bold>Data</bold><break/> <bold>type</bold></th>
<th valign="top" align="left"><bold>Primary outcome</bold></th>
<th valign="top" align="left"><bold>Language</bold></th>
<th valign="top" align="left"><bold>Uses</bold></th>
<th valign="top" align="left"><bold>Data</bold></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2017.00487">The Detection of Phase Amplitude Coupling during Sensory Processing</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2017.00487">Seymour et al.</ext-link></td>
<td valign="top" align="left">Sup. mat.</td>
<td/>
<td valign="top" align="left">MEG</td>
<td valign="top" align="left">Phase amplitude coupling</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">Fieldtrip</td>
<td valign="top" align="left">Yes</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00006">Group Analysis in MNE-Python of Evoked Responses from a Tactile Stimulation Paradigm: A Pipeline for Reproducibility at Every Step of Processing, Going from Individual Sensor Space Representations to an across-Group Source Space Representation</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00006">Andersen</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://github.com/ualsbombe/omission_frontiers">GitHub</ext-link></td>
<td/>
<td valign="top" align="left">MEG</td>
<td valign="top" align="left">Beamformer</td>
<td valign="top" align="left">Python</td>
<td valign="top" align="left">MNE</td>
<td valign="top" align="left">Yes</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00048">Group-Level EEG-Processing Pipeline for Flexible Single Trial-Based Analyses Including Linear Mixed Models</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00048">Fr&#x000F6;mer et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://osf.io/hdxvb/">OSF</ext-link></td>
<td/>
<td valign="top" align="left">EEG</td>
<td valign="top" align="left">Linear mixed model</td>
<td valign="top" align="left">MATLAB and R</td>
<td valign="top" align="left">EEGLAB; Fieldtrip</td>
<td valign="top" align="left">Yes</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00097">The Harvard Automated Processing Pipeline for Electroencephalography (HAPPE): Standardized Processing Software for Developmental and High-Artifact Data</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00097">Gabard-Durnam et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://github.com/lcnhappe/happe">HAPPE</ext-link> site</td>
<td valign="top" align="left">GNU/ GPL</td>
<td valign="top" align="left">EEG</td>
<td valign="top" align="left">Automated pre-processing</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">EEGLAB</td>
<td valign="top" align="left">Yes</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00236">Computational Testing for Automated Preprocessing 2: Practical Demonstration of a System for Scientific Data-Processing Workflow Management for High-Volume EEG</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00236">Cowley and Korpela</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://github.com/bwrc/ctap">CTAP</ext-link> site</td>
<td valign="top" align="left">MIT</td>
<td valign="top" align="left">EEG</td>
<td valign="top" align="left">Automated pre-processing</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">EEGLAB</td>
<td valign="top" align="left">Yes</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00261">Group Analysis in FieldTrip of Time-Frequency Responses: A Pipeline for Reproducibility at Every Step of Processing, Going From Individual Sensor Space Representations to an Across-Group Source Space Representation</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00261">Andersen</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://github.com/ualsbombe/omission_frontiers">Personal</ext-link> site</td>
<td/>
<td valign="top" align="left">MEG</td>
<td valign="top" align="left">Beamformer</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">Fieldtrip</td>
<td valign="top" align="left">Yes</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00306">How to Build a Functional Connectomic Biomarker for Mild Cognitive Impairment From Source Reconstructed MEG Resting-State Activity: The Combination of ROI Representation and Connectivity Estimator Matters</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00306">Dimitriadis et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://figshare.com/articles/code/MATLAB_CODE/6127298">Figshare</ext-link></td>
<td/>
<td valign="top" align="left">MEG</td>
<td valign="top" align="left">Connectivity analysis</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">Fieldtrip</td>
<td valign="top" align="left">Yes</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00309">Source-Modeling Auditory Processes of EEG Data Using EEGLAB and Brainstorm</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00309">Stropahl et al.</ext-link></td>
<td valign="top" align="left">Sup. Mat.</td>
<td/>
<td valign="top" align="left">EEG</td>
<td valign="top" align="left">Source analysis</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">EEGLAB; Brainstorm</td>
<td valign="top" align="left">Yes</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00355">A Student&#x00027;s Guide to Randomization Statistics for Multichannel Event-Related Potentials Using Ragu</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00355">Habermann et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="http://www.thomaskoenig.ch/index.php/work/ragu/1-ragu">Ragu</ext-link> site</td>
<td valign="top" align="left">GNU/ GPL</td>
<td valign="top" align="left">EEG</td>
<td valign="top" align="left">ERP; Microstates</td>
<td valign="top" align="left">MATLAB</td>
<td/>
<td valign="top" align="left">Yes</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00368">From ERPs to MVPA Using the Amsterdam Decoding and Modeling Toolbox (ADAM)</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00368">Fahrenfort et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://github.com/fahrenfort/ADAM">ADAM</ext-link> site</td>
<td valign="top" align="left">GNU/ GPL</td>
<td valign="top" align="left">EEG</td>
<td valign="top" align="left">MVPA</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">EEGLAB; Fieldtrip</td>
<td valign="top" align="left">Yes (HW)</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00468">Group-Level Multivariate Analysis in EasyEEG Toolbox: Examining the Temporal Dynamics Using Topographic Responses</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00468">Yang et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://github.com/ray306/EasyEEG">EasyEEG</ext-link> site</td>
<td valign="top" align="left">GNU/ GPL</td>
<td valign="top" align="left">EEG</td>
<td valign="top" align="left">ERP; Classification</td>
<td valign="top" align="left">Python</td>
<td valign="top" align="left">MNE</td>
<td valign="top" align="left">Yes (HW)</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00513">BEAPP: The Batch Electroencephalography Automated Processing Platform</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00513">Levin et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://github.com/lcnbeapp/beapp">BEAP</ext-link> site</td>
<td valign="top" align="left">GNU/ GPL</td>
<td valign="top" align="left">EEG</td>
<td valign="top" align="left">Automated pre-processing</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">EEGLAB; PREP; HAPPE</td>
<td valign="top" align="left">Yes <xref ref-type="table-fn" rid="TN1"><sup>&#x02020;</sup></xref></td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00530">A Reproducible MEG/EEG Group Study With the MNE Software: Recommendations, Quality Assessments, and Good Practices</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00530">Jas et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://github.com/mne-tools/mne-python">MNE</ext-link> site</td>
<td valign="top" align="left">BSD</td>
<td valign="top" align="left">EEG/<break/> MEG</td>
<td valign="top" align="left">General purpose</td>
<td valign="top" align="left">Python</td>
<td valign="top" align="left">MNE</td>
<td valign="top" align="left">Yes (HW)</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00586">Analysis of Functional Connectivity and Oscillatory Power Using DICS: From Raw MEG Data to Group-Level Statistics in Python</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00586">van Vliet et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://mne.tools/mne-biomag-group-demo/">MNE</ext-link> site</td>
<td/>
<td valign="top" align="left">EEG/<break/> MEG</td>
<td valign="top" align="left">Connectivity analysis</td>
<td valign="top" align="left">Python</td>
<td valign="top" align="left">MNE</td>
<td valign="top" align="left">Yes (HW)</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00587/full">BrainWave: A MATLAB Toolbox for Beamformer Source Analysis of MEG Data</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00587">Jobst et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://cheynelab.utoronto.ca/brainwave.php">Brainwave</ext-link> site</td>
<td valign="top" align="left">GNU/ GPL</td>
<td valign="top" align="left">MEG</td>
<td valign="top" align="left">Beamformer</td>
<td valign="top" align="left">MATLAB</td>
<td/>
<td valign="top" align="left">Yes</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00598">Bayesian Model Selection Maps for Group Studies Using M/EEG Data</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00598">Harris et al.</ext-link></td>
<td valign="top" align="left">Sup. Mat</td>
<td/>
<td valign="top" align="left">EEG/<break/> MEG</td>
<td valign="top" align="left">Bayesian Model Selection Maps</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">SPM</td>
<td valign="top" align="left">Yes</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00603">Task-Evoked Dynamic Network Analysis Through Hidden Markov Modeling</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00603">Quinn et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://github.com/OHBA-analysis/Quinn2018_TaskHMM">GitHub</ext-link></td>
<td/>
<td valign="top" align="left">MEG</td>
<td valign="top" align="left">Dynamic Network Analysis using Hidden Markov Models</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">SPM; OSL</td>
<td valign="top" align="left">Yes (HW)</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00711">FieldTrip Made Easy: An Analysis Protocol for Group Analysis of the Auditory Steady State Brain Response in Time, Frequency, and Space</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00711">Popov et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://data.donders.ru.nl/collections/di/dccn/DSC_3015000.00_810?0">Fieldtrip</ext-link> site</td>
<td valign="top" align="left">GNU/ GPL</td>
<td valign="top" align="left">EEG/<break/> MEG</td>
<td valign="top" align="left">General purpose</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">Fieldtrip</td>
<td valign="top" align="left">Yes</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2018.00765">Estimating the Timing of Cognitive Operations With MEG/EEG Latency Measures: A Primer, a Brief Tutorial, and an Implementation of Various Methods</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2018.00765">Liesefeld</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://github.com/Liesefeld/latency">GitHub</ext-link></td>
<td/>
<td valign="top" align="left">EEG/<break/> MEG</td>
<td valign="top" align="left">Timing of cognitive operations</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">Fieldtrip</td>
<td valign="top" align="left">Yes (HW)</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2019.00076">MEG/EEG Group Analysis With Brainstorm</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2019.00076">Tadel et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://github.com/brainstorm-tools/brainstorm3">Brainstorm</ext-link> site</td>
<td valign="top" align="left">GNU/ GPL</td>
<td valign="top" align="left">EEG/<break/> MEG</td>
<td valign="top" align="left">Group analysis; Source localization</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">Brainstorm</td>
<td valign="top" align="left">Yes (HW)</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2019.00241">MEG Source Imaging and Group Analysis Using VBMEG</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2019.00241">Takeda et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://vbmeg.atr.jp">VBMEG</ext-link> site</td>
<td valign="top" align="left">GNU/ GPL</td>
<td valign="top" align="left">MEG</td>
<td valign="top" align="left">MRI based connectivity analysis</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">Freesurfer</td>
<td valign="top" align="left">Yes (HW)</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2019.00284">Brainstorm Pipeline Analysis of Resting-State Data From the Open MEG Archive</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2019.00284">Niso et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://github.com/brainstorm-tools/brainstorm3">Brainstorm</ext-link> site</td>
<td valign="top" align="left">GNU/ GPL</td>
<td valign="top" align="left">MEG</td>
<td valign="top" align="left">Resting state analysis</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">Brainstorm</td>
<td valign="top" align="left">Yes</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2019.00300">Multimodal Integration of M/EEG and f/MRI Data in SPM12</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2019.00300">Henson, et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://figshare.com/collections/Multimodal_integration_of_M_EEG_and_f_MRI_data_in_SPM12/4367120">Figshare</ext-link></td>
<td/>
<td valign="top" align="left">EEG/<break/> MEG/<break/> fMRI</td>
<td valign="top" align="left">Multimodal integration of EEG/MEG with fMRI</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">SPM</td>
<td valign="top" align="left">Yes (HW)</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2020.00710">NUTMEG: Open Source Software for M/EEG Source Reconstruction</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2020.00710">Hinkley et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://github.com/UCSFBiomagneticImagingLab/nutmeg">NUTMEG</ext-link> site</td>
<td valign="top" align="left">GNU/ GPL and BSD</td>
<td valign="top" align="left">EEG/<break/> MEG</td>
<td valign="top" align="left">EEG/MEG source reconstruction</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">NUTMEG</td>
<td valign="top" align="left">Yes</td>
</tr>
<tr>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fnins.2020.610388/full">From BIDS-Formatted EEG Data to Sensor-Space Group Results: A Fully Reproducible Workflow With EEGLAB and LIMO EEG</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fnins.2020.610388">Pernet et al.</ext-link></td>
<td valign="top" align="left"><ext-link ext-link-type="uri" xlink:href="https://github.com/LIMO-EEG-Toolbox/limo_meeg/wiki">LIMO</ext-link> site</td>
<td valign="top" align="left">GNU/ GPL and BSD</td>
<td valign="top" align="left">EEG</td>
<td valign="top" align="left">Automated processing; EEG statistical analysis</td>
<td valign="top" align="left">MATLAB</td>
<td valign="top" align="left">EEGLAB and LIMO</td>
<td valign="top" align="left">Yes (HW)</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p><italic>HW stands for Henson Wakeman face dataset. Sup. Mat. indicate that the article processing scripts are available in supplemental material.</italic></p>
<fn id="TN1">
<label>&#x02020;</label>
<p><italic>Data not referenced in the article but available at <ext-link ext-link-type="uri" xlink:href="https://zenodo.org/record/998965">https://zenodo.org/record/998965</ext-link></italic>.</p></fn>
</table-wrap-foot>
</table-wrap>
<p>The articles in this special issue focus on different aspects of MEEG data processing. Some articles processed EEG data (<italic>n</italic> = 9), MEG data (<italic>n</italic> = 8), joint EEG/MEG data (<italic>n</italic> = 7), or even EEG/MEG/fMRI data (<italic>n</italic> = 1). Four articles focused on automated processing of EEG data, 10 dealt</p>
<p>with source localization, 3 with connectivity analysis, 3 with statistical analysis, 2 with EEG data classification. Other topics included microstates and Bayesian modeling. Submissions were based on existing MEEG software, in particular EEGLAB (<italic>n</italic> = 7), FieldTrip (<italic>n</italic> = 7), MNE (<italic>n</italic> = 4), SPM (<italic>n</italic> = 3), Brainstorm (<italic>n</italic> = 2), and NUTMEG (<italic>n</italic> = 1). Of the 25 articles, 21 are using MATLAB, 4 are using Python, and 1 is partially using R. Most scripts and tools were released under the GNU/GPL license (<italic>n</italic> = 10), BSD or MIT commercial friendly license (<italic>n</italic> = 2), no specific license (<italic>n</italic> = 11), or a combination of licenses (<italic>n</italic> = 2).</p>
<p>For researchers starting to process MEG/EEG data, we would recommend downloading the HW dataset (<ext-link ext-link-type="uri" xlink:href="https://doi.org/10.18112/openneuro.ds000117.v1.0.5">https://doi.org/10.18112/openneuro.ds000117.v1.0.5</ext-link>) and trying the methods described in this special issue. A simplified BIDS version of this dataset with EEG only is also available (<ext-link ext-link-type="uri" xlink:href="https://doi.org/10.18112/openneuro.ds002718.v1.0.5">https://doi.org/10.18112/openneuro.ds002718.v1.0.5</ext-link>). Furthermore, we recommend researchers to format their own data to BIDS to facilitate the application of some of the tools in this special issue and help the field move toward better tool integration centered on the BIDS framework.</p>
<p>Overall, there is tremendous potential in using different tools to process the same datasets. First, it forces tool developers to use a standard data format (BIDS) and increases interoperability between tools. Second, these tools offer common features, so the community may compare and check the numerical validity of each approach. Validity checking of MEEG signal processing approaches is important for open-source software, which often has limited resources assigned for testing purposes. Being able to process the same dataset using different tools also makes it simpler for users to compare them and see which one fits their style best, whether it is mixed GUI/script tools like EEGLAB, Brainstorm, SPM and NUTMEG or pure scripting tools such as Fieldtrip or MNE. Finally, making it possible to combine the signal processing pipelines of different tools allows users to develop approaches, leading to new methodological developments.</p>
<sec id="s1">
<title>Author Contributions</title>
<p>AD wrote the manuscript. RO, FT, AG, SN, and VL edited the manuscript. All authors contributed to the article and approved the submitted version.</p></sec>
<sec sec-type="COI-statement" id="conf1">
<title>Conflict of Interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p></sec>
<sec sec-type="disclaimer" id="s2">
<title>Publisher&#x00027;s Note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p></sec>
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