AUTHOR=Misirocchi Francesco , De Stefano Pia 

TITLE=Status epilepticus: the score question

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1721546

DOI=10.3389/fneur.2025.1721546

ISSN=1664-2295

ABSTRACT=Status epilepticus (SE) is a heterogeneous neurological emergency associated with high morbidity and mortality. Multiple prognostic scores have been developed, most of which primarily focus on short-term mortality. The Status Epilepticus Severity Score (STESS) and the Epidemiology-Based Mortality Score in SE (EMSE) remain the most extensively validated tools, while more recent models have addressed specific subgroups, functional outcomes, long-term survival, epilepsy development, and recurrence risk. Despite these advances, the predictive performance of current scores remains limited, largely due to reliance on post-hoc or subjective variables, lack of universally applicable cut-offs, and limited external validity. Moreover, their integration into clinical algorithms is minimal, confining their use mainly to retrospective risk adjustment in research context. Emerging approaches based on artificial intelligence offer improved predictive performance, but their clinical applicability is hampered by several issues. Future SE models should balance feasibility with accuracy, integrate variables across different stages of SE care, and align with standardized SE definitions and management, to become clinically valuable tools able to guide individualized SE management.