AUTHOR=Guo Tengyun , Hou Kunlin , Dong Jinqian , Yang Wenzhen , Guo Zhijian , Li Qiang 

TITLE=Neuroendoscopic resection of pineal region tumors via the transfrontal-transventricular-transforaminal approach

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1710012

DOI=10.3389/fneur.2025.1710012

ISSN=1664-2295

ABSTRACT=PurposeTo evaluate the clinical efficacy of neuroendoscopic resection of pineal region tumors via the transfrontal-transventricular-transforaminal approach.MethodsClinical data of eight patients with pineal region tumors who underwent this surgical approach at our institution between January 2020 and July 2025 were retrospectively reviewed.ResultsThe cohort consisted of seven males and one female, aged 3–52 years. Gross total resection (GTR) was achieved in three patients, near-total resection (NTR) in two, and subtotal resection (STR) in three. Three patients underwent combined radiotherapy and chemotherapy. Histopathological diagnoses included three mixed germ cell tumor, two low-grade glioma, one high-grade glioma, and one mature teratoma. Two patients developed subjective memory decline. During a follow-up period of 3–29 months, seven patients resumed normal daily activities, except for one who discontinued treatment due to tumor recurrence.ConclusionNeuroendoscopic resection of pineal region tumors via the transfrontal-transventricular-transforaminal approach is a safe and effective technique, particularly for lesions extending into the third ventricle.