AUTHOR=Huang Huiying , Wang Weijun , Ma Qing , Cao Kun 

TITLE=Systemic inflammation–based hematological indices and 90-day functional outcomes after intravenous thrombolysis in acute ischemic stroke: a systematic review

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1699939

DOI=10.3389/fneur.2025.1699939

ISSN=1664-2295

ABSTRACT=BackgroundAcute ischemic stroke (AIS) is one of the leading causes of mortality and long-term disability worldwide. Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) remains the standard treatment for eligible patients; however, considerable inter-individual variability exists in post-treatment functional outcomes. Increasing evidence suggests that systemic inflammation plays a crucial regulatory role in both ischemic injury cascades and reperfusion efficacy. In recent years, several inflammation-based hematological indices derived from complete blood counts—such as the neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), inflammation prognostic index (IPI), and pan-immune-inflammation value (PIV)—have been proposed. These indices comprehensively reflect the balance between innate immune activation and adaptive immune suppression and are considered potential prognostic biomarkers.MethodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically searched PubMed, Embase, and Web of Science for English-language studies published between 2015 and 2025 investigating the relationship between inflammation-based hematological indices and functional outcomes in adult AIS patients receiving intravenous rt-PA. Eligible studies were limited to IVT-only cohorts reporting associations between composite inflammatory indices and clinical outcomes. The search strategy was framed using the PICO (Population, Intervention, Comparison, and Outcome) approach, and study quality was assessed using the Newcastle–Ottawa Scale (NOS).ResultsA total of 15 observational cohort studies involving approximately 4,000 AIS patients were included. Higher baseline or early values of NLR, SII, SIRI, and PIV were independently associated with unfavorable 90-day functional outcomes, with predictive performance (AUC) generally ranging from 0.70 to 0.80. Several studies further indicated that dynamic changes in inflammatory indices within 24–48 h after IVT provided stronger prognostic discrimination than baseline measurements, underscoring the clinical value of early immune monitoring during the acute phase of stroke.ConclusionSystemic inflammation plays a central role in the pathophysiology and therapeutic response of AIS. Composite inflammation-based hematological indices are simple, economical, and reproducible tools that may assist in early risk stratification and individualized prognostic assessment following IVT. Future studies should incorporate dynamic longitudinal monitoring and integrate multimodal clinical and biomarker data within large, multicenter cohorts to improve model precision and enhance translational applicability.