AUTHOR=Sanner Johan , Thommessen Bente , von Euler Mia , Ström Jakob O. , Fure Brynjar 

TITLE=Acute stroke in persons 85 years or older—clinical characteristics, impact of frailty, and predictors of outcome

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1689225

DOI=10.3389/fneur.2025.1689225

ISSN=1664-2295

ABSTRACT=IntroductionStroke cases among older people will increase due to demographic changes, necessitating an optimization of care strategies for this population. We aimed to examine clinical characteristics, prognostic factors, and the impact of frailty in an older stroke cohort.Patients and methodsWe consecutively included 120 patients aged ≥85 years with acute ischemic or hemorrhagic stroke at a regional hospital in Sweden. Baseline characteristics, etiological subclassification, National Institutes of Health Stroke Scale (NIHSS) on admission, pre- and post-stroke functional level and frailty, measured by the modified Rankin Scale (mRS), the Barthel ADL Index (BI), and the Clinical Frailty Scale (CFS), were recorded. Regression analyses were conducted to evaluate predictors of death or poor functional outcome, defined as an mRS of ≥4, at 3 months.ResultsThe mean age was 89.1 years and 57.5% were women. Ischemic strokes accounted for 90.8% and atrial fibrillation was diagnosed in 55.8%. Overall, 26.6% received reperfusion therapy. At 3 months, the mortality and poor functional outcomes were 35.8 and 54.2%, respectively. A multivariate regression analysis identified age ≥89 years, BI ≤70, CFS ≥ 7 prior to stroke, total anterior circulation infarction, NIHSS ≥15 on admission, and post-stroke dysphagia as independent predictors of death or poor outcome.Discussion and conclusionWe found a high prevalence of cardioembolic disease in older people with stroke, emphasizing the importance of diagnosing atrial fibrillation and optimizing anticoagulant treatment. In addition to well-known predictors, severe frailty prior to stroke and post-stroke dysphagia predicted poor outcome. In the growing older stroke population, assessment of frailty may be beneficial in decision-making regarding interventions and direction of care.