AUTHOR=Lv Zheng , Miao Yanrong , Zhu Meiying , Li Fei 

TITLE=Association between mean corpuscular volume and 3 month outcome in patients with acute ischemic stroke: a second analysis based on a prospective cohort study

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1675822

DOI=10.3389/fneur.2025.1675822

ISSN=1664-2295

ABSTRACT=IntroductionAcute ischemic stroke is a major cause of global mortality and disability. This study aimed to investigate the association between mean corpuscular volume (MCV) and 3-month outcomes in acute ischemic stroke patients.MethodsThis study is a secondary analysis based on a prospective cohort study conducted at a single center in Korea from January 2010 to December 2016. The study included 1,906 acute ischemic stroke patients. The exposure variable was MCV measured within 24 hours of admission, and the outcome variable was the modified Rankin Scale (mRS) score at 3 months post-admission. Covariates included age, gender, body mass index, hemoglobin, hematocrit, liver function indicators, diabetes history, and stroke etiology.ResultsPiecewise linear regression analysis revealed a non-linear U‑shaped association of MCV on adverse outcomes, with a critical turning point at 92.1 fl. After full adjustment (Model 3), when MCV was below 92.1 fL, each 1 fL increase was associated with an 8% lower odds of poor 3-month outcome (OR = 0.92, 95% CI: 0.88–0.96, p = 0.0003). Conversely, when MCV exceeded 92.1 fL, each 1 fL increase was associated with a 4% higher odds of poor outcome (OR = 1.04, 95% CI: 1.00–1.08, p = 0.0391).ConclusionThere was a U‑shaped association between MCV and three-month outcome in patients with acute ischemic stroke.