AUTHOR=Zhang Xizhen , Zhang Xiaoli , Chen Fuming 

TITLE=A novel epileptic seizure prediction model based on Cox-Stuart and Optuna

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1624873

DOI=10.3389/fneur.2025.1624873

ISSN=1664-2295

ABSTRACT=ObjectivesIn order to more accurately predict whether patients with intractable epilepsy are about to develop seizures, this paper proposes an epilepsy prediction model.MethodsWhen the amount of targeted patient data is small, A Cox-Stuart and Convolutional Neural Network and Bi-directional Long Short-Term Memory (Cox-Stuart-CNN-BiLSTM) model based on multi-patient epilepsy prediction is proposed, which aims to capture common features of epileptic seizures by integrating EEG signal data from multiple patients to train the model. When there is enough data for targeted patient, an Optuna and Convolutional Neural Network and Bi-directional Long Short-Term Memory (Optuna-CNN-BiLSTM) model based on independent patient epilepsy prediction is proposed, which can train the model for EEG data of individual patients, aiming to better match physiological characteristics and seizure patterns of targeted patient.ResultsThe accuracy of the test set for multi-patient is 0.9992, the sensitivity is 0.9996, and the specificity is 0.9988; the average accuracy of the test set for independent patient is 0.9996, the sensitivity is 0.9995, and the specificity is 1.0000.ConclusionsIt can be proved that the method proposed in this paper has good experimental results.