AUTHOR=Zhang Shike , He Hui , Li Xinyu , Guo Yi 

TITLE=Electroacupuncture and vagus nerve stimulation are emerging therapies for hyperemesis gravidarum management

JOURNAL=Frontiers in Neurology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1615635

DOI=10.3389/fneur.2025.1615635

ISSN=1664-2295

ABSTRACT=Hyperemesis gravidarum (HG), an extreme form of nausea and vomiting during pregnancy (NVP), significantly impairs the quality of life of affected individuals. This review examines the multifactorial etiology of the HG and evaluates the efficacy of non-traditional therapeutic approaches, namely, vagus nerve stimulation (VNS) and electroacupuncture. By synthesizing a comprehensive body of literature, we highlight the neurophysiological mechanisms underlying these therapies and propose a novel model for the HG management. The model focuses on vagus nerve modulation through targeted stimulation at the auricular and cervical points, suggesting a promising avenue for effective and safe treatment strategies against the NVP/HG.