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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Neurol.</journal-id>
<journal-title>Frontiers in Neurology</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Neurol.</abbrev-journal-title>
<issn pub-type="epub">1664-2295</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fneur.2025.1537895</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Neurology</subject>
<subj-group>
<subject>Mini Review</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Stroke 1-2-0-3-6: rapid identification and timely action for stroke in China</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Chen</surname> <given-names>Chen</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x0002A;</sup></xref>
<uri xlink:href="http://loop.frontiersin.org/people/2898410/overview"/>
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<role content-type="https://credit.niso.org/contributor-roles/writing-original-draft/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author" equal-contrib="yes">
<name><surname>Hou</surname> <given-names>Ziwei</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="author-notes" rid="fn001"><sup>&#x02020;</sup></xref>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Li</surname> <given-names>Li</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Wang</surname> <given-names>Ruiying</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Liu</surname> <given-names>Hong</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Shen</surname> <given-names>Hui</given-names></name>
<xref ref-type="aff" rid="aff4"><sup>4</sup></xref>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
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<aff id="aff1"><sup>1</sup><institution>Shanxi Cardiovascular Hospital, Taiyuan</institution>, <addr-line>Shanxi</addr-line>, <country>China</country></aff>
<aff id="aff2"><sup>2</sup><institution>Shanxi Medical University</institution>, <addr-line>Taiyuan</addr-line>, <country>China</country></aff>
<aff id="aff3"><sup>3</sup><institution>Department of Neurology, Changzhi No. 2 People&#x00027;s Hospital of Shanxi Province, Changzhi</institution>, <addr-line>Shanxi</addr-line>, <country>China</country></aff>
<aff id="aff4"><sup>4</sup><institution>Department of Neurology, Shanxi Cardiovascular Hospital, Taiyuan</institution>, <addr-line>Shanxi</addr-line>, <country>China</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited by: Patricia Pia Wadowski, Medical University of Vienna, Austria</p></fn>
<fn fn-type="edited-by"><p>Reviewed by: Vikas Bhatia, Post Graduate Institute of Medical Education and Research (PGIMER), India</p></fn>
<corresp id="c001">&#x0002A;Correspondence: Chen Chen <email>13934161870&#x00040;163.com</email></corresp>
<fn fn-type="equal" id="fn001"><p>&#x02020;These authors have contributed equally to this work and share first authorship</p></fn></author-notes>
<pub-date pub-type="epub">
<day>02</day>
<month>04</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="collection">
<year>2025</year>
</pub-date>
<volume>16</volume>
<elocation-id>1537895</elocation-id>
<history>
<date date-type="received">
<day>02</day>
<month>12</month>
<year>2024</year>
</date>
<date date-type="accepted">
<day>17</day>
<month>03</month>
<year>2025</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x000A9; 2025 Chen, Hou, Li, Wang, Liu and Shen.</copyright-statement>
<copyright-year>2025</copyright-year>
<copyright-holder>Chen, Hou, Li, Wang, Liu and Shen</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<abstract>
<p>In 2016, doctors in China proposed the Chinese version of FAST, called Stroke 120, to improve stroke identification and response in the Chinese population. And we modified Stroke 120 by adding &#x0201C;3&#x0201D; and &#x0201C;6&#x0201D; which aimed to reduce the prehospital delays and improve the prognosis of patients with stroke.</p></abstract>
<kwd-group>
<kwd>stroke</kwd>
<kwd>1-2-0-3-6</kwd>
<kwd>rapid identification</kwd>
<kwd>timely action</kwd>
<kwd>China</kwd>
</kwd-group>
<counts>
<fig-count count="3"/>
<table-count count="0"/>
<equation-count count="0"/>
<ref-count count="4"/>
<page-count count="3"/>
<word-count count="1114"/>
</counts>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Stroke</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<p>Stroke is the leading cause of disability and death worldwide, and the incidence of stroke is higher in China than in most other countries (<xref ref-type="bibr" rid="B1">1</xref>). In 2007, American scholars proposed the Facial drooping, Arm weakness, Speech difficulties and Time to call emergency services (FAST) stroke educational tool (<xref ref-type="bibr" rid="B2">2</xref>). In 2016, doctors in China proposed the Chinese version of FAST, called Stroke 120, to improve stroke identification and response in the Chinese population (<xref ref-type="bibr" rid="B3">3</xref>).</p>
<p>The meaning of Stroke 120 is as follows: number 1 represents &#x0201C;check whether the face is asymmetrical;&#x0201D; 2 represents &#x0201C;examine the two arms for weakness&#x0201D;; and 0 represents &#x0201C;(absence of) clear speech.&#x0201D; The detection rate of stroke by family doctors has increased by 12.5% in China (<xref ref-type="bibr" rid="B4">4</xref>). However, some shortcomings remain in this approach. First, &#x0201C;FAS&#x0201D; in FAST emphasizes the symptoms, &#x0201C;T&#x0201D; emphasizes time, and the word FAST itself again emphasizes immediate action. Although Stroke 120 emphasizes the symptoms and emergency helpline number, it ignores the important window for timely response. Furthermore, it seems that there are still many people who do not understand the meaning of &#x0201C;one face&#x0201D; and &#x0201C;two arms.&#x0201D;</p>
<p>Therefore, we modified Stroke 120 by adding &#x0201C;3&#x0201D; and &#x0201C;6.&#x0201D; Numbers 1 and 2 represent 1/2, emphasizing &#x0201C;paralysis or numbness of half the body;&#x0201D; and 0 still means &#x0201C;(absence of) clear speech.&#x0201D; However, three emphasizes the window for intravenous thrombolysis for cerebral infarction, i.e., 3 h, and 6 denotes the window for arterial thrombectomy for cerebral infarction i.e., 6 h (<xref ref-type="fig" rid="F1">Figure 1</xref>). Finally, Stroke 12036 represents recognizing the symptoms and dialing 120 in 3 and 6 h.</p>
<fig id="F1" position="float">
<label>Figure 1</label>
<caption><p>Stroke educational tool in USA and China. <bold>Left panel</bold>: FAST. <bold>Middle panel</bold>: Stroke 1-2-0. <bold>Right panel</bold>: Stroke 1-2-0-3-6. (In right panel, the differents from the previous version are shown in red).</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fneur-16-1537895-g0001.tif"/>
</fig>
<p>Among these numbers, 120 is the emergency helpline number that Chinese people are familiar with; and 36 is a multiple of 12. Therefore, 12036 is easier to understand and remember than FAST. In addition to recognizing the symptoms by 120, there is a sense of urgency for 3 and 6 h. This tool was designed and released three times on Douyin account (the Chinese version of the video application TikTok). The video was played more than 400,000 times and shared nearly 20,000 times, indicating that the masses easily understood and accepted stroke 12036 (<xref ref-type="fig" rid="F2">Figure 2</xref>).</p>
<fig id="F2" position="float">
<label>Figure 2</label>
<caption><p>Study design flow chart.</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fneur-16-1537895-g0002.tif"/>
</fig>
<p>We now plan to test this new strategy locally to establish a more suitable and final plan for China&#x00027;s family doctors and the general population. We aim to reduce the prehospital delays and improve the prognosis of patients with stroke (<xref ref-type="fig" rid="F3">Figure 3</xref>).</p>
<fig id="F3" position="float">
<label>Figure 3</label>
<caption><p>Flow chart of future research plans.</p></caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fneur-16-1537895-g0003.tif"/>
</fig>
</body>
<back>
<sec sec-type="author-contributions" id="s1">
<title>Author contributions</title>
<p>CC: Conceptualization, Writing &#x02013; original draft. ZH: Writing &#x02013; review &#x00026; editing. LL: Writing &#x02013; review &#x00026; editing. RW: Writing &#x02013; review &#x00026; editing. HL: Writing &#x02013; review &#x00026; editing. HS: Writing &#x02013; review &#x00026; editing.</p>
</sec>
<sec sec-type="funding-information" id="s2">
<title>Funding</title>
<p>The author(s) declare that financial support was received for the research and/or publication of this article. This work was financially supported by Four Batches Innovation Project of Invigorating Medical through Science a Technology of Shanxi Province (2022XM07); Scientific Research Incentive Fund of Shanxi Cardiovascular Hospital (XYS20220107); Shanxi Province Chinese Medicine Science and Technology special research project (2024ZYY2A023).</p>
</sec>
<ack><p>We would like to thank Editage (<ext-link ext-link-type="uri" xlink:href="https://www.editage.cn/">https://www.editage.cn/</ext-link>) for English language editing.</p>
</ack>
<sec sec-type="COI-statement" id="conf1">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="ai-statement" id="s3">
<title>Generative AI statement</title>
<p>The author(s) declare that no Gen AI was used in the creation of this manuscript.</p>
</sec>
<sec sec-type="disclaimer" id="s4">
<title>Publisher&#x00027;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
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</article>