AUTHOR=Prabha Devi D. , Palanisamy C. TITLE=Early heart disease prediction using LV-PSO and Fuzzy Inference Xception Convolution Neural Network on phonocardiogram signals JOURNAL=Frontiers in Neuroinformatics VOLUME=Volume 19 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/neuroinformatics/articles/10.3389/fninf.2025.1655003 DOI=10.3389/fninf.2025.1655003 ISSN=1662-5196 ABSTRACT=IntroductionHeart disease is one of the leading causes of mortality worldwide, and early detection is crucial for effective treatment. Phonocardiogram (PCG) signals have shown potential in diagnosing cardiovascular conditions. However, accurate classification of PCG signals remains challenging due to high dimensional features, leading to misclassification and reduced performance in conventional systems.MethodsTo address these challenges, we propose a Linear Vectored Particle Swarm Optimization (LV-PSO) integrated with a Fuzzy Inference Xception Convolutional Neural Network (XCNN) for early heart risk prediction. PC G signals are analyzed to extract variations such as delta, theta, diastolic, and systolic differences. A Support Scalar Cardiac Impact Rate (S2CIR) is employed to capture disease specific scalar variations and behavioral impacts. LV-PSO is used to reduce feature dimensionality, and the optimized features are subsequently trained using the Fuzzy Inference XCNN model to classify disease types.ResultsExperimental evaluation demonstrates that the proposed system achieves superior predictive performance compared to existing models. The method attained a precision of 95.6%, recall of 93.1%, and an overall prediction accuracy of 95.8% across multiple disease categories.DiscussionThe integration of LV-PSO with Fuzzy Inference XCNN enhances feature selection aPSO with Fuzzy Inference XCNN enhances feature selection and nd classification accuracy, significantly improving the diagnostic capabilities of PCG-classification accuracy, significantly improving the diagnostic capabilities of PCG-based systems. These results highlight the potential of the proposed framework as a based systems. These results highlight the potential of the proposed framework as a reliable tool for early heart disease prediction and clinical decision support.reliable tool for early heart disease prediction and clinical decision support.