AUTHOR=Gangadhar Lekshmi , Subburaj Saranyadevi TITLE=Nanotechnology advances for biomedical applications JOURNAL=Frontiers in Nanotechnology VOLUME=Volume 7 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/nanotechnology/articles/10.3389/fnano.2025.1639506 DOI=10.3389/fnano.2025.1639506 ISSN=2673-3013 ABSTRACT=Nanotechnology has recently emerged as a revolutionary force in the field of biomedical science, offering innovative solutions to complex challenges in diagnostics, drug delivery, tissue engineering, and disease therapeutics. The current sources of nanotechnology and their implications on biomedical applications have been discussed in this review. Nanomaterials are widely used in medical applications because these materials possess some peculiar physicochemical properties. Particularly in cancer, infectious diseases, and chronic diseases, because of its size, available surface area, and responsive surface, it has enhanced therapies, better medication delivery, and superior targeting of medications. Nanotechnology allows the design of drug delivery systems that have advanced carriers that release drug formulations in response to specific stimuli in the neighborhood. Nanotechnology has also increasingly contributed to early disease diagnosis by combining it with diagnostic equipment. These innovations have prophesied non-invasive diagnostics that accelerate and enhance the diagnosis of diseases at the molecular level. Regenerative medicine has benefited from nanotechnology through the design of nano scaffolds that promote tissue regeneration and support stem cell therapies. In addition, the start of the application of nanomaterials in immunotherapy has provided novel directions in the development of antigen-directed vaccines and immune modulation. Despite the vast potential, the translation of nanotechnological innovations from laboratory research to clinical applications encounters difficulties with cost, safety, adaptability, and approval from regulatory bodies. In addition, the review addresses the potential future paths of nanotechnology in biomedicine, including the integration of artificial intelligence, the development of multifunctional nanodevices, and the promise of theranostics. Nanotechnology has the enormous possibility to transform healthcare in the future by offering accurate, individualized, and successful therapies for a variety of illnesses.