AUTHOR=Xing Dan , Gong Yingxun , Xia Weiyi , Tu Huifang , Yuan Limei , Yin Yiqing , Wang Kaiyuan 

TITLE=Dynamic glycosylation remodeling in neurological disorders

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=Volume 18 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2025.1674665

DOI=10.3389/fnmol.2025.1674665

ISSN=1662-5099

ABSTRACT=Glycosylation, a crucial post-translational modification, involves the covalent attachment of monosaccharides or oligosaccharides to proteins. This process significantly influences protein stability and function. Within the nervous system, glycosylation regulates key processes including neuronal differentiation, migration, synapse formation, and neurotransmitter release and signaling. Its proper functioning is essential for maintaining neuronal homeostasis and reducing the risk of neurological disorders. Understanding the specific mechanisms by which glycosylation impacts the central nervous system is therefore essential for developing novel therapeutic strategies. This review focuses on the roles of three major glycosylation types–N-glycosylation, O-glycosylation, and O-GlcNAcylation–in the pathogenesis of central nervous system disorders.