AUTHOR=Jia Shuai Ying , Tang Xiao-Jun , Su Yao , Liu Yu-Ning , Ming Zhi , Lin Jing-Yan 

TITLE=The role and mechanisms of matrix metalloproteinase-9 in peripheral neuropathic pain

JOURNAL=Frontiers in Molecular Neuroscience

VOLUME=Volume 18 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2025.1647316

DOI=10.3389/fnmol.2025.1647316

ISSN=1662-5099

ABSTRACT=Peripheral neuropathic pain is a chronic, secondary pain state caused by damage or diseases of the peripheral nervous system, typically accompanied by edema, inflammatory responses, increased neuronal excitability, and glutamate accumulation. Matrix metalloproteinase-9 (MMP-9), an important enzyme, plays a key role in various physiological and pathological processes, primarily by degrading the extracellular matrix. Recent studies have shown that MMP-9 plays a crucial role in the onset and progression of central nervous system disorders, particularly neuropathic pain. This review discusses the mechanisms underlying the involvement of MMP-9 in various models of peripheral neuropathic pain, with the aim of exploring its potential as a therapeutic target.