AUTHOR=Cui Qi , Jia Keran , Li Fang , Zheng Jie , Wang Fukun 

TITLE=Post-translational modifications in heat stress-related diseases

JOURNAL=Frontiers in Molecular Biosciences

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2025.1666874

DOI=10.3389/fmolb.2025.1666874

ISSN=2296-889X

ABSTRACT=Post-translational modifications (PTMs) act as pivotal molecular hubs integrating heat stress signals into cellular responses driving heat-related diseases like heatstroke. This review synthesizes evidence demonstrating that dynamic PTM networks—including phosphorylation, acetylation, ubiquitination, methylation, SUMOylation, and S-nitrosylation—orchestrate pathophysiology through three distinctive mechanisms: PTM crosstalk, tissue-specific PTM signatures defining organ vulnerability, and translational utility. The potentials of PTM alterations as novel biomarkers for early diagnosis/prognosis and PTM-targeted interventions as therapeutic strategies are discussed. By delineating how PTMs reconfigure proteostasis, metabolism, and inflammation, this review provides a mechanistic framework for targeting PTM pathways to mitigate heatstroke and related conditions.