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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Mol. Biosci.</journal-id>
<journal-title>Frontiers in Molecular Biosciences</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Mol. Biosci.</abbrev-journal-title>
<issn pub-type="epub">2296-889X</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">1137613</article-id>
<article-id pub-id-type="doi">10.3389/fmolb.2023.1137613</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Molecular Biosciences</subject>
<subj-group>
<subject>Editorial</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Editorial: Protein-Material interfaces: Fundamentals and applications volume II</article-title>
<alt-title alt-title-type="left-running-head">Faccio and Asuri</alt-title>
<alt-title alt-title-type="right-running-head">
<ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fmolb.2023.1137613">10.3389/fmolb.2023.1137613</ext-link>
</alt-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Faccio</surname>
<given-names>Greta</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="corresp" rid="c001">&#x2a;</xref>
<uri xlink:href="https://loop.frontiersin.org/people/224561/overview"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Asuri</surname>
<given-names>Prashanth</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/1057592/overview"/>
</contrib>
</contrib-group>
<aff id="aff1">
<sup>1</sup>
<institution>Independent Researcher</institution>, <addr-line>St. Gallen</addr-line>, <country>Switzerland</country>
</aff>
<aff id="aff2">
<sup>2</sup>
<institution>Department of Bioengineering</institution>, <institution>Santa Clara University</institution>, <addr-line>Santa Clara</addr-line>, <addr-line>CA</addr-line>, <country>United States</country>
</aff>
<author-notes>
<fn fn-type="edited-by">
<p>
<bold>Edited and reviewed by:</bold> <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/10644/overview">Ralf Metzler</ext-link>, University of Potsdam, Germany</p>
</fn>
<corresp id="c001">&#x2a;Correspondence: Greta Faccio, <email>greta.faccio@gmail.com</email>
</corresp>
<fn fn-type="other">
<p>This article was submitted to Biophysics, a section of the journal Frontiers in Molecular Biosciences</p>
</fn>
</author-notes>
<pub-date pub-type="epub">
<day>17</day>
<month>01</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="collection">
<year>2023</year>
</pub-date>
<volume>10</volume>
<elocation-id>1137613</elocation-id>
<history>
<date date-type="received">
<day>04</day>
<month>01</month>
<year>2023</year>
</date>
<date date-type="accepted">
<day>09</day>
<month>01</month>
<year>2023</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#xa9; 2023 Faccio and Asuri.</copyright-statement>
<copyright-year>2023</copyright-year>
<copyright-holder>Faccio and Asuri</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<related-article id="RA1" related-article-type="commentary-article" journal-id="Front. Mol. Biosci." xlink:href="https://www.frontiersin.org/researchtopic/29079" ext-link-type="uri">Editorial on the Research Topic <article-title>Protein-Material interfaces: Fundamentals and applications volume II</article-title>
</related-article>
<kwd-group>
<kwd>functional surface</kwd>
<kwd>protein immobilisation</kwd>
<kwd>functional material</kwd>
<kwd>biosensor</kwd>
<kwd>enzyme immobilization</kwd>
</kwd-group>
</article-meta>
</front>
<body>
<p>When scientists work at the interface and investigate how to tailor it, they can unlock a plethora of possibilities for the future of different sectors. This is well exemplified by the five articles published as a part of this research topic; these works can contribute to development of natural delivery systems for cosmeceutical applications, bio-inspired functional surfaces for biomedical, biosensing, and food packaging, as well as techniques for the measurement of protein adsorption. Following from the previous research topic (Editorial: <italic>Protein-Material interfaces: Fundamentals and applications</italic>), this second volume explores how proteins can interact with surfaces and how these interactions may be intentionally applied to alter surface properties and introduce novel functionalities.</p>
<p>We can understand and study only what we can measure and the review article on nanomechanical mass spectrometry presents the crucial role of nanomechanical techniques in the understanding of protein deposition at the surface. This research topic also features a review article on hydrophobins, a protein with a tight affinity for surfaces that can self-assemble at hydrophobic/hydrophilic interfaces into amphipathic layers, and shines light on the potential applications of hydrophobins from fungi.</p>
<p>As a complementary approach to lab studies, <italic>in silico</italic> predictions of protein structures often offers access to information that is inaccessible experimentally through X-ray crystallography or electron microscopy. Using a protein structure prediction program (AlphaFold2, AF2), the conformation of the adhesion devices of <italic>Streptococcus thermophilus</italic> was studied. This study demonstrates the ability of AF2 to unveil structural and functional details of the molecular machineries involved in adhesion of bacteriophages to their hosts.</p>
<p>The important issue of sustainability has also received attention in the submitted works; alginate and chitosan polymers has been investigated by two papers &#x2013; one that describes the delivery of bee products for cosmeceuticals and medical applications, and a second that explores nanocomposite film based-sensors based on catalase.</p>
<p>What will the future bring? Hopefully a better understanding of the single molecule events at the surface and ways to better tune and exploit them, while the current innovations reach the market and deliver impact.</p>
</body>
<back>
<sec id="s1">
<title>Author contributions</title>
<p>All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication.</p>
</sec>
<ack>
<p>The guest editors wish to thank the authors for their valuable contributions, as well as the many reviewers for the tremendous efforts to guarantee a high-quality review process.</p>
</ack>
<sec sec-type="COI-statement" id="s2">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="disclaimer" id="s3">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
</back>
</article>