Front. Mol. Biosci. Frontiers in Molecular Biosciences Front. Mol. Biosci. 2296-889X Frontiers Media S.A. 763338 10.3389/fmolb.2021.763338 Molecular Biosciences Review A Review on the Role of miR-1290 in Cell Proliferation, Apoptosis and Invasion Ghafouri-Fard et al. miR-1290 and Tumorigenesis Ghafouri-Fard Soudeh 1 Khoshbakht Tayyebeh 2 Hussen Bashdar Mahmud 3 Taheri Mohammad 4 5 * Samadian Mohammad 6 * 1 Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2 Men’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3 Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Iraq 4 Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 5 Institute of Human Genetics, Jena University Hospital, Jena, Germany 6 Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Edited by: Wei Ye, Guangdong Academy of Science, China

Reviewed by: Abbas Salihi, Salahaddin University, Iraq

Amin Safa, Complutense University of Madrid, Spain

Rezvan Noroozi, Jagiellonian University, Poland

 *Correspondence: Mohammad Taheri, mohammad_823@yahoo.com; Mohammad Samadian, mdsamadian@gmail.com

This article was submitted to RNA Networks and Biology, a section of the journal Frontiers in Molecular Biosciences

 24 12 2021 2021 8 763338 23 08 2021 24 11 2021 Copyright © 2021 Ghafouri-Fard, Khoshbakht, Hussen, Taheri and Samadian. 2021 Ghafouri-Fard, Khoshbakht, Hussen, Taheri and Samadian

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MicroRNAs (miRNAs) have been shown to affect expression of several genes contributing in important biological processes. miR-1290 a member of this family with crucial roles in the carcinogenesis. This miRNA is transcribed from MIR1290 gene on chromosome 1p36.13. This miRNA has interactions with a number of mRNA coding genes as well as non-coding RNAs SOCS4, GSK3, BCL2, CCNG2, KIF13B, INPP4B, hMSH2, KIF13B, NKD1, FOXA1, IGFBP3, CCAT1, FOXA1, NAT1, SMEK1, SCAI, ZNF667-AS1, ABLIM1, Circ_0000629 and CDC73. miR-1290 can also regulate activity of JAK/STAT3, PI3K/AKT, Wnt/β-catenin and NF-κB molecular pathways. Most evidence indicates the oncogenic roles of miR-1290, yet controversial evidence also exists. In the present review, we describe the results of in vitro, animal and human investigations about the impact of miR-1290 in the development of malignancies.

 miR-1290 cancer biomarker miRNA expression Introduction

MicroRNAs (miRNAs) are a group of small-sized transcripts with a wide range of regulatory roles. They are mostly produced through a multistep mechanism. These steps include transcription from DNA sequences into primary miRNAs and processing into precursor miRNAs and subsequently into mature miRNAs. The majority of bind with the 3′ untranslated region (3′ UTR) of target transcripts to either degrade mRNA or repress its translation. In some circumstances, miRNAs can induce translation or control transcription (O'Brien et al., 2018). Approximately 50% of all miRNAs are transcribed from intragenic regions. These miRNAs are mainly produced from introns and a number of exons of protein coding genes. Other miRNAs are intergenic and are produced in an independent manner from a host gene. Thus, these miRNAs have their own promoters (Kim and Kim, 2007; De Rie et al., 2017). miRNAs partake in the regulation of important biological functions, such as cell proliferation, differentiation and apoptosis, thus being involved in the pathoetiology of several disorders, particularly neoplastic disorders (Peng and Croce, 2016). These transcripts participate in the pathoetiology of diverse cancers (Abolghasemi et al., 2020).

miR-1290 is transcribed from MIR1290 gene on chromosome 1p36.13. The primary transcript (NR_031622.1) has 78 nucleotides (GAG​CGU​CAC​GUU​GAC​ACU​CAA​AAA​GUU​UCA​GAU​UUU​GGA​ACA​UUU​CGG​AUU​UUG​GAU​UUU​UGG​AUC​AGG​GAU​GCU​CAA). The mature transcript of hsa-miR-1290 (MIMAT0005880) has 19 nucleotides (UGG​AUU​UUU​GGA​UCA​GGG​A). This miRNA has important functions in the carcinogenesis. Several in vitro studies have assessed function of miR-1290. Moreover, animal studies in lung, colon and liver cancer models have assessed functional consequences of up-regulation or silencing of this miRNA. However, some inconsistencies exist regarding the role of miR-1290. In the present manuscript, we describe the results of in vitro, animal and human assays about the influence of miR-1290 in the development of cancers.

 <italic>In vitro</italic> Studies

Forced over-expression of miR-1290 in AsPC1 and Panc5.04 pancreatic cancer cell lines has led to enhancement of cell proliferation. Inhibition of miR-1290 in pancreatic cancer cells has the reverse effects. miR-1290 mimics have also enhanced invasive properties of these cells (Li et al., 2013).

Over-expression of miR-1290 has enhanced proliferation of proliferation of lung adenocarcinoma cells and induced cell cycle progression and invasiveness. Moreover, this miRNA has suppressed cell apoptosis in this cell line. miR-1290 has been found to downregulate expression of SOCS4 to activate JAK/STAT3 and PI3K/AKT pathways (Xiao et al., 2018).

The anti-proliferative and apoptosis-inducing agent polygonatum odoratum lectin (POL) has been shown to decrease miR-1290 levels in A549 lung adenocarcinoma cells. Down-regulation of miR-1290 has been shown to increase POL-associated apoptosis in these cells. GSK3β has been found as the direct target of miR-1290 in A549 cells (Wu et al., 2016). Conversely, miR-1290 has been shown to sensitize A549 cells to the apoptosis-inducing agent asiatic acid through negatively regulating expression of BCL2. Expression of miR-1290 has been up-regulated by asiatic acid. Most notably, the apoptosis-inducing effect of asiatic acid relies on miR-1290 activity. Taken together, miR-1290 has been shown to suppress viability and cell cycle progression of A549 cells (Kim et al., 2014). Figure 1 summarizes the effects of miR-1290 in the pathoetiology of lung cancer.

Dual roles of miR-1290 in the pathoetiology of lung cancer.

In oral squamous cell carcinoma, miR-1290 has been shown to be up-regulated parallel with downregulation of CCNG2. miR-1290 silencing has inhibited metastatic ability and epithelial-mesenchymal transition (EMT). CCNG2 has been identified as the direct target of miR-1290 (Qin et al., 2019). Functional studies in laryngeal squamous cell carcinoma has shown that miR-1290 targets two tumor suppressor genes, namely ITPR2 and MAF (Janiszewska et al., 2015).

miR-1290 has oncogenic roles in colorectal cancer. miR-1290 silencing has suppressed proliferation of colorectal cancer cells. miR-1290 up-regulation has decreased expression of p27 and enhanced transcript and protein amounts of cyclin D1. NPP4B has been recognized as the target of miR-1290 (Ma et al., 2018). Moreover, miR-1290 silencing has improved cytotoxic effects of 5-fluouracil in colorectal cancer cells through targeting hMSH2 (Ye et al., 2017). Figure 2 shows the oncogenic role of miR-1290 in squamous cell carcinoma and colorectal cancer.

Oncogenic influence of miR-1290 in squamous cell carcinoma and colorectal cancer.

Exosomal miR-1290 has been found to be high in gastric cancer cell lines. miR-1290-containing exosomes could promote proliferation, migratory aptitude, and invasiveness of gastric cancer cells. NKD1 has been identified as the direct target of miR-1290 in these cells (Huang et al., 2019). Moreover, miR-1290 has been revealed to increase proliferation and migratory aptitude of gastric cancer cells through targeting FOXA1 (Lin et al., 2016).

miR-1290 has also been shown to be overexpressed in B-acute lymphoblastic leukemia (ALL) cell line SUP-B15. The anticancer agent resveratrol has been found to down-regulate expression of miR-1290 and enhance IGFBP3 levels in the ALL cells. miR-1290 can target 3′ UTR of IGFBP3 (Zhou et al., 2017). Besides, exosomal miR-1290 has been demonstrated to promote angiogenic processes in hepatocellular carcinoma through influencing expression of SMEK1 (Wang et al., 2021c).

On the other hand, miR-1290 has been shown to exert tumor suppressive role in ovarian cancer. In fact, the oncogenic long non-coding RNA (lncRNA) CCAT1 facilitates ovarian carcinogenesis through decreasing miR-1290 levels (Lai and Cheng, 2018).

Figure 3 shows the roles of miR-1290 in gastric cancer, ALL, hepatocellular carcinoma and ovarian cancer.

miR-1290 has oncogenic roles in gastric cancer, acute lymphoblastic leukemia and hepatocellular carcinoma, while it has tumor suppressive roles in ovarian cancer.

Over-expression of miR-1290 has enhanced esophageal squamous cell carcinoma growth, migration and invasiveness through decreasing SCAI levels (Li et al., 2015). In bladder cancer cells, tumor suppressor Circular RNA circ_0000629 has been shown to exert its effects through suppressing miR-1290 levels and up-regulating CDC73 expression (Wang et al., 2021b). Figure 4 shows the oncogenic role of miR-1290 in esophageal and bladder cancers.

Oncogenic role of miR-1290 in esophageal and bladder cancers.

Summary of in vitro studies regarding the role of miR-1290 in the carcinogenesis is provided in Table 1.

Expression pattern of miR-1290 in cancer cell lines (∆: knock-down or deletion, POL: Polygonatum odoratum lectin, 5-FU: 5-Fluorouracil).

Tumor type Targets/Regulators and signaling pathways Cell line Function References
Pancreatic cancer — Panc5.04, Panc8.13, Panc10.05, Panc198, HPDE ↑ miR-1290: ↑ proliferation, ↑ invasion Li et al. (2013)
Lung cancer SOCS4, JAK/STAT3 signaling pathway, PI3K/AKT signaling pathway BEAS-2B, A549, SPC-A1 ↑ miR-1290: ↑ proliferation, ↑ invasion, ↓ G1/G0 phase arrest, ↓ apoptosis Xiao et al. (2018)
GSK3, Wnt/-catenin pathway A549 POL treatment: ↓ miR-1290 Wu et al. (2016)
↑ miR-1290 + POL treatment: ↓ POL-induced apoptosis
∆ miR-1290 + POL treatment: ↑ POL-induced apoptosis
↑ miR-1290: did not affect proliferation, did not affect autophagy
∆ miR-1290: did not affect proliferation, did not affect autophagy
BCL2 A549 asiatic acid treatment: ↑ miR-1290 Kim et al. (2014)
↑ miR-1290: ↑ acid-induced apoptosis
Oral squamous cell carcinoma CCNG2 NHOK, Cal-27, SCC-9, SCC-25, Tca-8113 c ∆ miR-1290: ↓ migration, ↓ invasion Qin et al. (2019)
↑ miR-1290: ↑ EMT process
Laryngeal squamous cell carcinoma KIF13B  UT-SCC-34 — Janiszewska et al. (2015)
Colorectal cancer INPP4B FHC, and CRC cells SW480, HT-29, COLO205, SW403, KM202L, SW620 ↑ miR-1290: ↑ proliferation Ma et al. (2018)
∆ miR-1290: ↓ proliferation
— Caco2, DLD1, HT29, LoVo, SW480 ∆ miR-1290: ↓ proliferation, ↓ migration, ↓ invasion Imaoka et al. (2016)
hMSH2  RKO, SW480, HCT116, and LoVo ↑ miR-1290: ↑ viability, ↓ sensitivity to 5-FU Ye et al. (2017)
∆ miR-1290: ↑ sensitivity to 5-FU, ↑ apoptosis
KIF13B, Akt and NF-kB pathways SW620, 293T, SGC7901 c ↑ miR-1290: ↑ proliferation, ↑ reprogramming, ↓ cytokinesis Wu et al. (2013)
Gastric cancer NKD1 SGC7901, AGS, and BGC823, GES ↑ miR-1290: ↑ proliferation, ↑ invasion, ↑ migration  Huang et al. (2019)
FOXA1 GES-1, SGC-7901 ∆ miR-1290: ↓ proliferation, ↓ migration, no significant difference in apoptosis Lin et al. (2016)
Acute lymphoblastic leukemia IGFBP3 PBMCs ∆ miR-1290: ↑ cell cycle arrest, ↑ apoptosis Zhou et al. (2017)
Ovarian cancer CCAT1 OVCAR-8, SKOV-3 w, IOSE386, OMC685 ∆ lncRNA CCAT1 (which sponges miR-1290): ↓ proliferation, ↓ migration Lai and Cheng, (2018)
Breast cancer FOXA1, NAT1 T47D, MCF-7 ↑ miR-1290: ↓ expression levels of FOXA1 and NAT1 in ER-positive breast cancer cells Endo et al. (2013)
Hepatocellular carcinoma SMEK1 HUVECs, Hep3 B, HepG2, SMMC-7721, PLC/PRF/5, L-02 ↑ miR-1290: ↑ migration, ↑ viability, ↑ capacity of HUVECs to form tube-like structures Wang et al. (2021c)
∆ miR-1290: ↓ migration, ↓ viability, ↑ apoptosis
Esophageal squamous cell carcinoma SCAI Eca109, TE13 ↑ miR-1290: ↑ proliferation, ↑ invasion, ↑ migration Li et al. (2015)
Chordoma NONHSAT024778, Robo1 U-CH1 ↑ NONHSAT024778 (which sponges miR-1290): ↑ proliferation, ↑ invasion, ↑ migration Wang et al. (2021a)
Nasopharyngeal carcinoma ZNF667-AS1, ABLIM1 NP69, c666-1, CNE-1, CNE-2, HNE1 ↑ miR-1290: ↑ proliferation, ↑ invasion, ↑ migration, ↓ apoptosis Chen et al. (2020)
Bladder cancer Circ_0000629, CDC73 T24, SW780 ↑ miR-1290: ↑ growth, ↑ invasion, ↑ migration, ↓ apoptosis Wang et al. (2021b)

Studies in animal models.

miRNA-1290 has important roles in determination of response of cancer cells to 5-fluouracil. miR-1290 silencing has improved cytotoxic effects of 5-fluouracil in xenografts models of this cancer via targeting hMSH2 (Ye et al., 2017). Other studies have shown oncogenic roles of miR-1290 in animal models of lung cancer (Xiao et al., 2018), hepatocellular carcinoma (Wang et al., 2021c) and nasopharyngeal carcinoma (Chen et al., 2020) (Table 2). On the other hand, animal studies have shown that the oncogenic lncRNA NONHSAT024778 acts through sponging miR-1290, thus revealing a tumor suppressor role for miR-1290 (Wang et al., 2021a).

Impact of miR-1290 in carcinogenesis based on investigations in animal models (∆: knock-down or deletion).

Tumor type Animal models Results References
Lung cancer BALB/c-nu/nu nude mice ↑ miR-1290: ↑ tumor volume, ↑ tumor weight, ↑ invasion, ↑ metastasis Xiao et al. (2018)
Colon cancer male BALB/c nude mice ∆ miR-1290: ↑ 5-FU-induced apoptosis Ye et al. (2017)
Hepatocellular carcinoma male BALB/c and NOD-SCID mice ∆ miR-1290: ↓ tumor volumes, ↓ tumor weights, ↓ proliferation, ↑ apoptosis Wang et al. (2021c)
Chordoma male Balb/c NOD nude mice ∆ NONHSAT024778 (which sponges miR-1290): ↓ tumor volumes, ↓ tumor weights, ↓ tumor growth Wang et al. (2021a)
Nasopharyngeal carcinoma BALB/c nude mice ∆ miR-1290: ↓ tumor volumes, ↓ tumor weights Chen et al. (2020)
Studies in Clinical Samples

In lung adenocarcinoma tissues, expression of miR-1290 has been negatively correlated with SOCS4 levels. Expression of SOCS4 has been inversely correlated with higher clinical stages and lymph node metastases (Xiao et al., 2018). Moreover, miR-1290 levels have been associated with clinicopathological landscapes and poor prognosis of patients with oral squamous cell carcinoma (Qin et al., 2019). In laryngeal squamous cell carcinoma, a high throughput miRNA profiling experiment has shown up-regulation of 33 miRNAs, among them being miR-1290 (Janiszewska et al., 2015).

Comparison of miRNA profiles between deficient and proficient mismatch repair colon cancer tissues has shown up-regulation of miR-1290 in deficient mismatch repair colorectal cancer tissues. Expression of miR-1290 has been correlated with poor prognoses of colon cancer in stages II and III patients who took 5-fluouracil-based chemotherapeutics regimens (Ye et al., 2017).

miR-1290 has also been exhibited to be up-regulated in serum exosomes of gastric cancer patients compared with healthy people (Huang et al., 2019). Another study in gastric cancer patients has shown correlation between miR-1290 over-expression and clinical stage, deepness of invasion and lymph node positivity (Lin et al., 2016).

miR-1290 has also been shown to be upregulated in esophageal squamous cell carcinoma tissues compared with unaffected neighboring samples. Over-expression of miR-1290 has been associated with level of differentiation, N classification TNM stage in this type of esophageal cancer (Li et al., 2015).

On the other hand, in oral squamous cell carcinoma, levels of this miRNA has been reported to be decreased in blood samples of patients compared with control samples (Nakashima et al., 2019). Moreover, expression of miR-1290 has been reported to be decreased in chordoma samples (Wang et al., 2021a). Table 3 summarizes the results of studies that reported dysregulation of miR-1290 in clinical samples.

Dysregulation of miR-1290 in clinical specimens (DC: benign pancreatic disease controls, PFS: progression free survival, LUAD: Lung adenocarcinoma, ANCTs: adjacent non-cancerous tissues, OS: Overall survival, DFS: disease-free survival, TNM: tumor-node-metastasis, NSCLC: non-small-cell lung cancer, CRA: colorectal adenoma, HGSOC: high grade serous ovarian cancer, EOC: epithelial ovarian cancer, HGSOC: high grade serous ovarian carcinoma.).

Tumor type Samples Expression (tumor vs. Normal) Kaplan-Meier analysis (impact of miR-1290 up-regulation) Univariate/Multivariate cox regression Association of miR-1290 expression with clinicopathologic characteristics References
Prostate cancer 23 CRPC patients up Poor OS — — Huang et al. (2015)
Pancreatic cancer (PC) GEO datasets: (GSE113486 and GSE106817) up — — — Wei et al. (2020)
120 PC patients, 40 DC patients, and 40 healthy controls  up — miR-1290 expression was independent risk factors for PC. gender (male), and stage III and IV
167 PC patients and 267 healthy subjects up shorter OS and DFS miR-1290 was not found to be an independent negative prognostic factor for OS and DFS in PC patients PC aggressiveness Tavano et al. (2018)
81 PDAC patients, 28 PNETs patients, 20 IPMN patients, 45 chronic pancreatitis patients, and 39 healthy controls higher in patients with IPMNs than healthy controls, higher in patients with invasive pancreatic cancer than patients with IPMNs, higher in intermediate- and high-grade dysplasia than those with low-grade dysplasia — — — Li et al. (2013)
Lung cancer 70 LUAD patients and 40 healthy controls up shorter PFS The level of miR-1290 was an independent prognostic factor in LUAD patients gender (male), advanced TNM stage, tumor size, lymph node metastasis, distant metastasis, smoking, and drinking Wu et al. (2020)
32 pairs of LUAD tissues and ANCTs up — — — Xiao et al. (2018)
33 pairs of NSCLC tissues and ANCTs up shorter OS — stage IIIa, lymph node metastasis  Mo et al. (2015)
serum samples from 73 NSCLC patients, 19 patients with various benign lung disease, 34 healthy controls up shorter OS TNM stage and lymph node metastasis status and serum miR-1290 expression were found to be the independent prognostic factors for OS. TNM stage, lymph node metastasis
Oral squamous cell carcinoma (OSCC) 47 pairs of OSCC tissues and ANCTs up shorter OS — TNM stage and the lymph node metastasis Qin et al. (2019)
10 OSCC patients and 10 healthy volunteers down — — — Nakashima et al. (2019)
plasma samples from 55 OSCC patients down higher OS and DFS Expression OF miR-1290 was found to be a significant prognostic factor for OSCC patients tumor differentiation and response to CRT
Laryngeal squamous cell carcinoma (LSCC) 50 LSCC patients and 5 epithelial no tumor controls up — — — Janiszewska et al. (2015)
5 pairs of LSCC tissues and ANCTs up — — — Sun et al. (2013)
48 LSCC patients up — — —
Colorectal cancer (CRC) GEO datasets: (GSE108153, GSE81581, GSE55139 and GSE41655) up — — — Liu et al. (2019)
15 CRC patients, 15 adenoma cases and 15 healthy controls up — — —
80 CRC patients, 50 adenoma cases, and 30 healthy controls up — — larger tumor size, advanced TNM stage, lymph node metastasis, and distant metastasis
8 pairs of CRC tissues and ANCTs up — — — Ma et al. (2018)
20 normal colon samples and 50 CRC samples up — — —
12 pairs of CRC tissues and ANCTs, and 12 colorectal adenomas tissues up poorer OS High miR-1290 expression, large tumor size, lymphatic invasion, venous invasion, high T stage, lymph node metastasis, distant metastasis, and high carcinoembryonic antigen levels were associated with poor OS. — Imaoka et al. (2016)
serum samples from 12 CRC patients,12 adenoma patients, and 12 healthy persons up worse OS Increased serum miR-1290 level, poor differentiation, lymphatic invasion, venous invasion, high T stage, lymph node metastasis, distant metastasis, and high CEA levels were associated with poor OS. —
serum samples from 211 CRC patients, 56 colorectal adenoma patients, and 57 healthy controls up — — stage IV, tumor size, serosal invasion, lymphatic and venous invasion, and metastasis
GEO database: GSE39833 (88 CRC patients and 11 healthy controls) up — — — Li et al. (2016)
Colorectal cancer (CRC) 54 CRA patients up — — adenoma size Handa et al. (2021)
Colon cancer 291 colon cancer tumor tissues up Lower OS and DFS miR-1290 expression, N stage, AJCC stage, tumor differentiation, vascular invasion, miR-and MMR status were associated with decreased OS and DFS. dMMR Status, tumor location, N stage, and tumor differentiation  Ye et al. (2017)
25 pairs of colon cancer tissues and ANCTs up — — — Wu et al. (2013)
Gastric cancer (GC) serum samples from 20 GC patients and 10 healthy controls up — — — Huang et al. (2019)
20 pairs of GC tissues and ANCTs up — — advanced clinical staging and depth of tumor invasion Lin et al. (2016)
Acute lymphoblastic leukemia (ALL) 15 ALL patients and 15 healthy controls IGFBP3 (a target of miR-1290) expression is decreased — — — Zhou et al. (2017)
Ovarian cancer (OC) sera samples from 70 EOC patients and 13 healthy controls no significant difference — — — Kobayashi et al. (2018)
30 HGSOC patients and 13 healthy controls up — — tumor burden
40 pairs of OC tissues and ANCTs upregulation of lncRNA CCAT1 (which sponges miR-1290) higher CCAT1 = shorter OS — tumor size and lymph node metastasis Lai and Cheng, (2018)
Breast cancer blood samples from 60 breast cancer patients and 20 healthy controls up — — lymph node metastasis and Stage II/III  Li et al. (2021)
4 ER-high Ki67-low tumor tissues and 4 ER-low Ki67-high tumor tissues down in ER-high Ki67-low tumors — — tumor grade Endo et al. (2013)
Hepatocellular carcinoma (HCC) 49 pairs of HCC tissues and ANCTs Up — — — Wang et al. (2021c)
serum samples of 49 HCC patients and serum samples of 28 healthy controls Up — — —
Esophageal squamous cell carcinoma (ESCC) 24 pairs of ESCC tumor tissues and ANCTs up — — differentiation, N classification and tumor-node-metastasis stage Li et al. (2015)
Chordoma 20 chordoma tissues and 10 FNP tissues down — — — Wang et al. (2021a)
Nasopharyngeal carcinoma (NPC) GEO database: (GSE70970) up — — — Chen et al. (2020)
Cutaneous squamous cell carcinoma (cSCC) 8 cSCC patients and 8 controls up — — — Geusau et al. (2020)
Cervical cancer sera from 6 cervical cancer patients and 6 healthy persons up — — — Nagamitsu et al. (2016)
Sera of 20 cervical cancer patients 10 healthy persons up — — —
serum samples from 100 cervical cancer patients and 31 healthy controls up — — —
microarray analysis up in cells with HPV infection upon 5-AZA treatment — — — Yao et al. (2013)

Serum levels of miR-1290 have been shown to be higher in patients with intraductal papillary mucinous pancreatic cancer compared with healthy subjects. The ability of serum levels of miR-1290 in separation of patients with low-stage pancreatic cancer from controls has been higher than CA19-9. Notably, higher levels of miR-1290 has been predictive of poor outcome following pancreaticoduodenectomy (Li et al., 2013). In this type of cancer, miR-1290 has been shown to appropriately distinguish neoplastic condition from both healthy condition and chronic pancreatitis (Wei et al., 2020). In colorectal cancer, levels of this miRNA could distinguish cancer status from healthy condition with up to ideal diagnostic power. Moreover, it can separate colorectal adenoma from healthy status with lower values (Imaoka et al., 2016). Table 4 shows the diagnostic value of miR-1290 in cancers.

Diagnostic value of miR-1290 in cancers (PC: pancreatic cancer; DC: benign pancreatic disease control; LUAD: Lung adenocarcinoma, EOC: epithelial ovarian cancer, HGSOC: high grade serous ovarian carcinoma).

Tumor type Samples Distinguish between Area under curve Sensitivity (%) Specificity (%) References
Pancreatic cancer (PC) 120 PC patients and 40 healthy controls PC patients vs. healthy controls 0.93 75.0 97.5 Wei et al. (2020)
120 PC patients and 40 DC PC patients vs. DC 0.89 88.3 72.5
120 PC patients and controls PC patients vs. all controls 0.91 74.2 91.2
81 PDAC patients and 39 healthy controls PDAC patients vs. healthy controls 0.96 — — Li et al. (2013)
81 PDAC patients and 45 chronic pancreatitis samples PDAC patients vs. chronic pancreatitis samples 0.81 — —
81 PDAC patients and 28 PNETs patients PDAC patients vs. PNET samples 0.80 — —
81 PDAC patients and all controlls PDAC patients vs. all controls 0.85 — —
Lung cancer 70 LUAD patients and 40 healthy controls LUAD patients vs. controls 0.937 80.0 96.7 Wu et al. (2020)
Colorectal cancer (CRC) 15 CRC patients, 15 colorectal adenoma patients and 15 healthy controls CRC patients vs. healthy controls 0.96 78.79 93.33 Liu et al. (2019)
colorectal adenoma patients vs. healthy controls 0.92 79.66 86.67
12 CRC patients,12 colorectal adenoma patients, and 12 healthy controls CRC patients vs. healthy controls 1.000 100 100 Imaoka et al. (2016)
colorectal adenoma patients vs healthy controls 0.722 50 100
211 CRC patients, 56 colorectal adenoma patients, and 57 healthy controls CRC patients vs. healthy controls 0.830 70.1% 91.2
colorectal adenoma patients vs. healthy controls 0.718 46.4 91.2
Ovarian cancer (OC) sera samples from 70 EOC patients and 13 healthy controls EOC patients vs. healthy controls 0.48 0.51 0.57 Kobayashi et al. (2018)
30 HGSOC patients and 13 healthy controls HGSOC patients vs. healthy controls 0.71 0.63 0.85
Discussion

Several miRNAs have been found to influence the carcinogenesis. miR-1290 is an example of oncomiRs based on the bulk of relevant evidence. This miRNA has interactions with several cancer-related mRNAs such as SOCS4, GSK3, BCL2, CCNG2, KIF13B, INPP4B, hMSH2, KIF13B, NKD1, FOXA1, IGFBP3, FOXA1, NAT1, SMEK1, SCAI, ZNF667-AS1, ABLIM1, and CDC73.

Moreover, miR-1290 has interactions with a number of non-coding RNAs such as Circ_0000629, CCTA1 and NONHSAT024778. The interaction between lncRNAs/circRNAs and miRNAs has important implications in pathoetiology of cancers, thus future studies are needed to identify other non-coding RNAs that interact with miR-1290 in the context of neoplastic conditions. In fact, these lncRNAs and circRNAs can act as sponge for miRNAs to decrease its bioavalability, thus enhancing expression of targets of miR-1290. Therefore, they construct a competing endogenous RNA (ceRNA) network.

In addition to its role in the regulation of gene expression, miR-1290 can regulate activity of JAK/STAT3, PI3K/AKT, Wnt/β-catenin and NF-κB signaling pathways, thus influencing several cancer-related routes.

Most evidence indicates the oncogenic roles of miR-1290, yet controversial evidence also exists. Particularly, in the lung cancer, both oncogenic and tumor suppressor roles have been reported for miR-1290.

A number of anticancer agents such as POL, asiatic acid and resveratrol has been shown to affect expression of miR-1290. Moreover, this miRNA can influence response of neoplastic cells to the chemotherapeutic agent 5-fluouracil. Thus, one can deduce that miR-1290-targeting strategies can modulate response of cancer cells to a wide variety of antineoplastic modalities.

In addition to its therapeutic implications, the existence of miR-1290 in cancer-derived exosomes not only indicates its application in diagnostic approaches, but also shows the effect of these vehicles in conferring neoplastic features inside the tumor bulk.

The ceRNA networks constructed by circRNAs, miR-1290 and target mRNAs can be used as prognostic biomarkers and therapeutic targets in different cancers. These ceRNA networks are superior to single transcripts since they reflect a more comprehensive overview of dysregulated pathways. Theoretically, the ceRNA regulatory networks including lncRNAs or circRNAs-miR-1290-mRNAs can be applied as prognostic biomarkers and therapeutic targets in different cancers. High throughput sequencing methods have facilitated applicability of these networks in diagnostic, prognostic and therapeutic fields. Moreover, these techniques have facilitated design of personalized therapeutic options based on the identified dysregulated networks in samples obtained from each patient. Application of this data can enhance survival of patients.

Cumulatively, miR-1290 is a cancer-related miRNA with possible application as diagnostic and prognostic marker in diverse types of cancers. Therapeutic applications of anti-miR-1290 modalities should be assessed in future. Moreover, future studies should address the possibility of targeting the miR1290-containg ceRNA networks.

 Author Contributions

SG-F wrote the draft and revised it. MT designed and supervised the study. TK and MS collected the data and designed the figures and tables. All the authors read and approved the submitted version.

 Conflict of Interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

 Publisher’s Note

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