AUTHOR=Hu Yanling , Yang Dongliang , Yuwen Lihui , Zeng Guisheng 

TITLE=Antibacterial nanoagents: an emerging arsenal against bacterial persisters

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2025.1688413

DOI=10.3389/fmicb.2025.1688413

ISSN=1664-302X

ABSTRACT=Bacterial persisters represent a metabolically dormant or slow-growing subpopulation within bacterial communities that exhibit resistance to antibiotics. These cells are capable of resuming active proliferation upon the removal of environmental stressors, hence serving as reservoirs for recurrent infections. Extensive clinical evidence links persister cell formation with chronic infection and post-therapeutic recurrence. In this minireview, we highlight the challenges in eradicating persisters and review recent advances in nanomaterial-based antimicrobial strategies that specifically target these resilient cells. We also discuss key translational barriers impeding the clinical application of antibacterial nanoagents. By integrating these insights, we aim to provide a conceptual roadmap for the development of next-generation therapies against persistent bacterial infections.