AUTHOR=Zhao Ying , Zeng Yan , Zeng Dong , Wang Hesong , Zhou Mengjia , Sun Ning , Xin Jinge , Khalique Abdul , Rajput Danish Sharafat , Pan Kangcheng , Shu Gang , Jing Bo , Ni Xueqin 

TITLE=Probiotics and MicroRNA: Their Roles in the Host–Microbe Interactions

JOURNAL=Frontiers in Microbiology

VOLUME=Volume 11 - 2020

YEAR=2021

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.604462

DOI=10.3389/fmicb.2020.604462

ISSN=1664-302X

ABSTRACT=Probiotics are widely accepted to be beneficial for the  maintenance of  the gut homeostasis - the dynamic and healthy interactions between host and gut microorganisms. In addition, emerging as a key molecule of inter-domain communication, microRNAs (miRNAs) can also mediate the host-microbe interactions. However, a comprehensive description and summary of the association between miRNA and probiotics have not been reported yet. In this review, we have discussed the roles of probiotics and miRNAs in host-microbe interactions, and proposed the association of probiotics with altered miRNAs in various intestinal diseases and potential molecular mechanisms underlying the action of probiotics. Furthermore, we provided a perspective of probiotics - miRNA - host/gut microbiota axis applied in search of disease management highly associated with the gut microbiome, which will potentially prove to be beneficial for future studies.