AUTHOR=Dai Yuanmin , Lou Jixian , Wen Jiquan , Liang Guanlu , Xu Jiehui , Jing Zhiguo , Wang Juanjuan 

TITLE=Simultaneous bilateral intravitreal anti-vascular endothelial growth factor injections from one vial for diabetic macular edema: a retrospective analysis

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1712378

DOI=10.3389/fmed.2025.1712378

ISSN=2296-858X

ABSTRACT=ObjectiveThe objective of this study was to assess the safety and efficacy of simultaneous bilateral intravitreal injections of anti-vascular endothelial growth factors (anti-VEGF) from a single vial for the treatment of diabetic macular edema (DME).MethodsA retrospective case series study was undertaken. The study population comprised patients who underwent intravitreal anti-vascular endothelial growth factor injections for DME at the Ophthalmology department of Zhejiang Hospital between January 2022 and May 2024. Participants were categorized into bilateral (n = 34, 102 injections) and unilateral (n = 93, 210 injections) groups. The primary outcome measures were best corrected visual acuity (BCVA) and central subfield thickness (CST), cube average thickness (CAT) along with the incidence of severe clinical complications. Statistical analysis was performed using the Mann-Whitney U test and Wilcoxon rank sum test.ResultsThere were no statistically significant differences in terms of age, gender, hypertension, years of diabetes, disorganization of the inner retinal layers (DRIL), ellipsoid zone (EZ) grade, BCVA, CST or CAT at baseline between the two groups. Both bilateral and unilateral injection groups demonstrated significant enhancements in BCVA at 1 month post-injection (P < 0.001; P < 0.001). A substantial decrease in CST and CAT were observed in both groups at 1 month post-injection (P < 0.001; P < 0.001; P < 0.000; P < 0.000). The median improvement in BCVA at 1 month post-injection relative to pre-injection was 8.0 letters (IQR: 3.0–19.0) in the bilateral injection group and 5.5 letters (IQR: 1.0–13.0) in the unilateral injection group, with a statistically significant difference between the two groups (P = 0.009). The reduction in CAT demonstrated significant difference between the two groups (P < 0.001). No severe complications, including cataract, retinal detachment, choroidal detachment, vitreous hemorrhage, or endophthalmitis, were reported in any of the patients.ConclusionSimultaneous bilateral anti-VEGF injections from a single vial are both safe and efficacious for the treatment of DME, thereby reducing the treatment burden, visit times and costs while enhancing patient compliance.