AUTHOR=Brănișteanu Daciana Elena , Lotti Torello , Colac Boțoc Cristina , Huțanu Antonia Elena , Munteanu Cătălina Anca , Ciobanu Roxana Paraschiva , Brănișteanu Daniel Constantin , Colac Alin Gabriel , Brănișteanu Cătălina Ioana Onu , Brănișteanu George , Toader Ștefan Vasile , Toader Mihaela Paula 

TITLE=Real-world outcomes with rituximab vs. conventional therapy in pemphigus vulgaris: a single-center Romanian cohort

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1691897

DOI=10.3389/fmed.2025.1691897

ISSN=2296-858X

ABSTRACT=BackgroundPemphigus vulgaris (PV) is a rare but potentially life-threatening autoimmune blistering disease. Rituximab has recently gained prominence as a first-line treatment for moderate-to-severe PV, yet real-world evidence from Eastern Europe remains limited. This study compares clinical outcomes of rituximab versus conventional corticosteroid-based therapy in a Romanian PV cohort.MethodsWe conducted a retrospective, single-center observational study including 17 patients diagnosed with PV between January 2021 and July 2025 in Iași, Romania. All patients initially received systemic corticosteroids with azathioprine or mycophenolate mofetil when indicated. Rituximab became available through the national reimbursement program in June 2024 and was prescribed for refractory or moderate-to-severe disease. Clinical outcomes assessed included time to disease control, remission and relapse rates, cumulative corticosteroid exposure, and adverse events.ResultsEight patients received rituximab and nine received conventional therapy. Rituximab led to faster disease control, with 100% of patients achieving control within 12 months compared with 55.6% in the conventional group. Complete remission at last follow-up was higher in the rituximab group (75%) than in the conventional group (44.4%). No relapses occurred in rituximab-treated patients during follow-up, whereas all patients treated conventionally experienced relapses (34 episodes in total). The cumulative corticosteroid dose was higher in the rituximab group (median 19.5 g vs. 15.5 g) due to prior exposure before therapy switch. Adverse events differed by treatment: rituximab was associated primarily with early infusion-related reactions and infections, while conventional therapy caused steroid-related toxicities.ConclusionIn this real-world cohort, rituximab demonstrated superior disease control and relapse prevention compared with conventional therapy. Despite limited follow-up, findings support earlier use of rituximab in PV management to reduce relapse burden and long-term corticosteroid exposure. Broader access to rituximab and improved diagnostic resources could meaningfully improve outcomes in resource-limited settings.