AUTHOR=Royeck Svenja , Papathanassiou Johanna , Weigel Angelika , Kindt Nell , Löwe Bernd , Mess Christian , Zeidler Claudia , Witte Felix , Agelopoulos Konstantin , Wiegmann Henning , Schneider Stefan W. , Ständer Sonja 

TITLE=Development of the pruritus-associated stress scale: a cross-sectional pilot study

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1683259

DOI=10.3389/fmed.2025.1683259

ISSN=2296-858X

ABSTRACT=BackgroundA significant relationship exists between perceived stress and the exacerbation and perpetuation of chronic pruritic dermatoses. Despite this, there is a notable absence of validated tools to specifically measure pruritus-associated stress.ObjectiveTo develop and pilot the Pruritus-Associated Stress Scale (PASS), a patient-reported outcome measure (PROM) for assessing pruritus-associated stress.Patients and methodsPatients with chronic prurigo (CPG), atopic dermatitis (AD), and chronic pruritus on non-lesional skin (CPNL) were recruited at a German university center. They were interviewed on pruritus-associated stress, and perceived stress using the PSS-10 and PSQ-30 questionnaires, to compile the first PASS version in accordance with the guidelines for PROM development. Subsequently, a second patient cohort was interviewed to refine the items of the PASS instrument based on impact analysis, interitem and item-total correlation, and internal consistency reliability.ResultsOf 55 patients (15 with AD, 20 with CPG, and 20 with CPNL; 61.8% female; mean age 61.0 ± 15.4 years), who participated in the item selection phase, 94.5% reported pruritus-associated stress in the previous 2 weeks. The preliminary PASS demonstrated excellent internal consistency (Cronbach’s alpha = 0.91). The 12 items that showed strong impact scores addressed nervousness, therapeutic strategies for managing pruritus-associated stress, fatigue, and urges to scratch more frequently or intensely due to pruritus.ConclusionThis pilot study yielded a preliminary PASS, identified poorly performing items, and collected information for further refinement. As a next step, retaining the full item pool, an exploratory factor analysis will be conducted in a larger sample.