AUTHOR=Guo Qiuyang , Wang Yumeng , Han Qiuyi , Yang Jinxiang , Zhang Jiayan , Li Guofang , Yang Yijun , Cheng Ruhong , Yao Zhirong 

TITLE=Case Report: Pediatric palisaded neutrophilic and granulomatous dermatitis without systemic diseases treated with sulfasalazine

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1670091

DOI=10.3389/fmed.2025.1670091

ISSN=2296-858X

ABSTRACT=Palisaded neutrophilic and granulomatous dermatitis (PNGD) is a rare neutrophilic dermatosis strongly associated with systemic conditions. Pediatric cases with exclusive cutaneous involvement are exceptionally rare. Current treatment options for PNGD include oral dapsone, hydroxychloroquine, and intralesional or systemic corticosteroids. Here we report a 6-years-old girl with skin-limited PNGD, presenting symmetric annular plaques on limb extensor surfaces and atypical lesions on the face, palms, and buttocks. Significant lesion resolution was achieved after 2 months of oral sulfasalazine therapy (25 mg/kg/day in divided doses), with only mild abdominal discomfort. To our knowledge, this represents the first successful use of sulfasalazine for PNGD, providing a dapsone-sparing alternative for pediatric PNGD.