AUTHOR=Garg Aastha , Gour Abha , Chauhan Nidhi , Sapra Mehak , Sangwan Virender Singh 

TITLE=Surgical management of chronic Stevens-Johnson syndrome

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1669189

DOI=10.3389/fmed.2025.1669189

ISSN=2296-858X

ABSTRACT=Stevens-Johnson Syndrome (SJS) is a rare but severe mucocutaneous disorder that often leads to chronic ocular complications, requiring a comprehensive and multidisciplinary approach to management. This review outlines the pathophysiology and long-term ocular sequelae of SJS and discusses evidence-based strategies for stabilizing the ocular surface and restoring visual function. Key interventions include punctal occlusion to address tear film instability, mucous membrane grafting (MMG) for lid margin reconstruction, and amniotic membrane transplantation (AMT) to promote epithelial healing and reduce inflammation. Cultivated oral mucosal epithelial transplantation (COMET) and minor salivary gland transplantation (MSGT) serve as advanced options for restoring ocular surface function in severe cases. The correction of cicatricial entropion, often seen in chronic SJS, involves techniques such as anterior lamellar repositioning with or without grafting, which restore lid alignment and reduce ocular trauma. Visual rehabilitation through cataract surgery or keratoprosthesis demands careful preoperative planning due to the fragile ocular surface and heightened risk of postoperative complications. A tailored, staged management plan focused on surface preservation, structural correction, and visual restoration is essential to improve outcomes and quality of life for patients with chronic ocular SJS.