AUTHOR=Hu Qing , Sun Lu , Xu Shijie , Hong Weidong , Tang Liangcheng , Li Feng , Wang Yougui 

TITLE=Analysis of risk factors for anastomotic leakage after radical esophagectomy for esophageal squamous cell carcinoma

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1668790

DOI=10.3389/fmed.2025.1668790

ISSN=2296-858X

ABSTRACT=ObjectiveAnastomotic leakage (AL) is one of the most common complications of radical surgery for esophageal cancer. This study aimed to analyze the risk factors for AL after radical esophagectomy for esophageal squamous cell carcinoma (ESCC) and construct a nomogram prediction model.MethodsWe retrospectively analyzed the clinical data of all patients who underwent radical esophagectomy between 2018 and 2023. Univariate and multivariable logistic regression analyses were used to identify the risk factors for AL. After screening the relevant variables, a prediction model for AL risk was established, and the predictive accuracy and clinical utility of the model were verified.ResultsA total of 107 patients with ESCC were included and the incidence of AL was 21.5% (23/107). In multivariate logistic regression analysis, age (OR 1.131, 95% CI 1.014–1.261, p = 0.027), anastomotic location (OR 5.747, 95% CI 1.754–18.828, p = 0.004), postoperative red blood cell (RBC) (OR 0.152, 95% CI 0.042–0.543, p = 0.004), and postoperative neutrophil to lymphocyte ratio (NLR) level (OR 1.096, 95% CI 1.017–1.182, p = 0.016) were considered as independent risk factors for the occurrence of AL. Based on the results of the multivariate logistic regression analysis, a nomogram was constructed, and the area under the receiver operating characteristic (ROC) curve (AUC) was0.870. The decision curve analysis (DCA) demonstrated the clinical utility of this model.ConclusionAge, anastomotic location, postoperative RBC count, and postoperative NLR were independent risk factors for AL after radical esophagectomy for ESCC. In addition, this study innovatively provides the mechanistic hypothesis linking cervical AL to the combined effects of anastomotic tension and impaired perfusion, offering a pathophysiological basis for its higher incidence than thoracic anastomosis.