AUTHOR=Lai Xinxuan , Zhang Qianjin , Liu Fuxin , Xu Zhiqing , Guo Jinhua , Qiu Hanglin , Xu Fudong , Zhuang Zhikun , Huang Changyu 

TITLE=Periprosthetic joint infection of the knee complicated by primary localized cutaneous amyloidosis: a case report

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1667350

DOI=10.3389/fmed.2025.1667350

ISSN=2296-858X

ABSTRACT=BackgroundPrimary localized cutaneous amyloidosis (PLCA) is characterized by amyloid protein deposition in the skin, leading to pigmentation, papules, and itching. The etiology of PLCA remains unclear. Periprosthetic joint infection (PJI) post-total knee arthroplasty (TKA) poses challenges in management.Case presentationA PLCA patient underwent TKA and developed acute PJI, necessitating multiple surgical interventions. Recurrence of infection symptoms prompted a two-stage revision surgery approach.ConclusionSkin lesions in PLCA patients may potentially contribute to the risk PJI following arthroplasty. Strategies such as using tacrolimus for itching management, along with prophylactic antibiotics during PLCA flare-ups, could potentially aid in preventing and managing PJI in this patient population. Further research is needed to elucidate the relationship between PLCA and PJI post-arthroplasty.