AUTHOR=Jiang Tao , Wang Shange , Xu Lin , Yin Ji , Zhang Linshuai , Zhang Yujie , Guo Jing , Zhang Pengfei 

TITLE=DMFF-Net: a multi-scale feature fusion network based on DeepLabV3 for skin lesion segmentation

JOURNAL=Frontiers in Medicine

VOLUME=Volume 12 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1633209

DOI=10.3389/fmed.2025.1633209

ISSN=2296-858X

ABSTRACT=ObjectiveIn computer-aided medical diagnosis, precise skin lesion segmentation is crucial for the early detection and treatment of skin cancer. However, challenges such as unclear lesion boundaries, low contrast, and varying lesion shapes make accurate segmentation a difficult task. To address these challenges, we propose DMFF-Net, a multi-scale, multi-attention feature fusion network based on DeepLabV3, designed to improve the accuracy of skin lesion segmentation.MethodsDMFF-Net integrates several advanced modules to enhance segmentation performance. The network incorporates a Global Grid Coordinate Attention Module (GGCAM), which effectively fuses spatial and channel features to capture the complex relationships between local and global information. Additionally, a Multi-Scale Depthwise Separable Dilated Convolution (MDSDC) module is employed to strengthen multi-scale feature extraction, thereby preventing resolution degradation during convolution. A Mid-High Level Feature Fusion (MHLFF) module is also introduced to refine critical feature representations and suppress irrelevant information, thereby improving segmentation accuracy.ResultsThe proposed network was evaluated on four publicly available datasets: ISIC 2016, ISIC 2017, ISIC 2018, and PH2. The results show that DMFF-Net significantly outperforms existing advanced methods. Specifically, it achieves MIoU values of 89.31%, 91.47%, and 86.93% on the ISIC 2016, ISIC 2017, and ISIC 2018 datasets, respectively. Furthermore, the network achieves accuracy values of 95.62%, 97.33%, and 94.78%, and F1 scores of 96.93%, 94.91%, and 93.61%, respectively, demonstrating its robustness and effectiveness in skin lesion segmentation.ConclusionThe DMFF-Net model, with its multi-scale feature fusion and attention mechanisms, substantially improves skin lesion segmentation by preserving crucial spatial details and improving feature representation. Its superior performance on multiple datasets highlights its potential as a powerful tool for skin lesion diagnosis and provides an important reference for future advancements in medical image segmentation.