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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Med.</journal-id>
<journal-title>Frontiers in Medicine</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Med.</abbrev-journal-title>
<issn pub-type="epub">2296-858X</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fmed.2024.1468654</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Medicine</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Decoding the interplay of medical professionalism, mental well-being, and coping in undergraduate medical students across culture: using structural equation modeling</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name><surname>Sattar</surname> <given-names>Kamran</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/1347439/overview"/>
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</contrib>
<contrib contrib-type="author" corresp="yes">
<name><surname>Meo</surname> <given-names>Sultan Ayoub</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="corresp" rid="c001"><sup>&#x002A;</sup></xref>
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<contrib contrib-type="author">
<name><surname>Yusoff</surname> <given-names>Muhamad Saiful Bahri</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref>
<uri xlink:href="https://loop.frontiersin.org/people/1347180/overview"/>
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<aff id="aff1"><sup>1</sup><institution>Department of Medical Education, College of Medicine, King Saud University</institution>, <addr-line>Riyadh</addr-line>, <country>Saudi Arabia</country></aff>
<aff id="aff2"><sup>2</sup><institution>Department of Physiology, College of Medicine, King Saud University</institution>, <addr-line>Riyadh</addr-line>, <country>Saudi Arabia</country></aff>
<aff id="aff3"><sup>3</sup><institution>Department of Medical Education, School of Medical Sciences, University Sains Malaysia</institution>, <addr-line>Kota Bharu</addr-line>, <country>Malaysia</country></aff>
<author-notes>
<fn fn-type="edited-by" id="fn0001">
<p>Edited by: Nian-Sheng Tzeng, National Defense Medical Center, Taiwan</p>
</fn>
<fn fn-type="edited-by" id="fn0002">
<p>Reviewed by: Antonio P. Gutierrez de Blume, Georgia Southern University, United States</p>
<p>Gohar Wajid, World Health Organization, EMRO, Egypt</p>
</fn>
<corresp id="c001">&#x002A;Correspondence: Sultan Ayoub Meo, <email>sultanmeo@hotmail.com</email>; <email>smeo@ksu.edu.sa</email></corresp>
</author-notes>
<pub-date pub-type="epub">
<day>05</day>
<month>11</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="collection">
<year>2024</year>
</pub-date>
<volume>11</volume>
<elocation-id>1468654</elocation-id>
<history>
<date date-type="received">
<day>22</day>
<month>07</month>
<year>2024</year>
</date>
<date date-type="accepted">
<day>25</day>
<month>10</month>
<year>2024</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2024 Sattar, Meo and Yusoff.</copyright-statement>
<copyright-year>2024</copyright-year>
<copyright-holder>Sattar, Meo and Yusoff</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<abstract>
<sec id="sec1">
<title>Introduction</title>
<p>The rigorous nature of medical education, long and night shifts, and prevalent issues like stress, anxiety, and depression affect medical students&#x2019; mental well-being and medical professionalism. This study aims to explore the intricate relationships between mental well-being, medical professionalism, and coping strategies, among undergraduate medical students, utilizing structural equation modeling (SEM) to unravel these dynamics.</p>
</sec>
<sec id="sec2">
<title>Methods</title>
<p>Conducted at Universiti Sains Malaysia, this cross-sectional study involved 234 medical students from the 1st, 3rd, and 5th years of the MBBS program. Data were collected via five validated survey instruments: DASS-9, TEQ, Dundee, Brief COPE, and CBI, through Google Forms. Participants were selected using purposive sampling. The surveys assessed mental well-being (burnout, anxiety, depression, stress), coping strategies, and medical professionalism attributes. Model fit was evaluated using established indices.</p>
</sec>
<sec id="sec3">
<title>Results</title>
<p>Findings indicated that professional behavior reduces burnout and negatively impacts negative coping strategies (NCSs). Additionally, medical professionalism indirectly enhances empathy and positively influences CSs. Conversely, psychological distress increases NCSs and reduces empathy. Positive coping strategies (PCSs) enhance empathy levels, while MWB issues elevate NCSs.</p>
</sec>
<sec id="sec4">
<title>Discussion</title>
<p>The study underscores the vital role of professional behavior in mitigating burnout and fostering positive coping mechanisms among medical students. Addressing MWB issues through targeted interventions can enhance empathy and professional behavior, ultimately improving the quality of patient care.</p>
</sec>
</abstract>
<kwd-group>
<kwd>relationship</kwd>
<kwd>medical professionalism</kwd>
<kwd>mental well-being</kwd>
<kwd>coping</kwd>
<kwd>undergraduate</kwd>
<kwd>medical students</kwd>
<kwd>medical education</kwd>
<kwd>cultural contexts</kwd>
</kwd-group>
<counts>
<fig-count count="5"/>
<table-count count="13"/>
<equation-count count="1"/>
<ref-count count="74"/>
<page-count count="15"/>
<word-count count="9451"/>
</counts>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Healthcare Professions Education</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec sec-type="intro" id="sec5">
<title>Introduction</title>
<p>Medical students confront a myriad of stressors throughout their training, which inevitably takes a toll on their mental well-being. Comparisons with the overall populace reveal an increase in mental disorders among medical students, indicating a pressing concern for their holistic health (<xref ref-type="bibr" rid="ref1">1</xref>). The demanding nature of medical education, characterized by the need to assimilate extensive information for examinations, adds an additional layer of pressure to an already challenging environment (<xref ref-type="bibr" rid="ref2">2</xref>). Hence, the mental well-being of medical students is currently gaining significant attention globally, largely due to their essential role as the backbone of future healthcare systems (<xref ref-type="bibr" rid="ref3">3</xref>, <xref ref-type="bibr" rid="ref4">4</xref>). It is clear that mental well-being issues, such as psychological distress (including stress, anxiety, and depression) and burnout, are prevalent among healthcare professionals (<xref ref-type="bibr" rid="ref5">5</xref>, <xref ref-type="bibr" rid="ref6">6</xref>). Hence, unidentified and untreated burnout and a distressed life are sure to hurt their health (individual), their performance (interpersonal), and their level of care for patients (societal). It is still not fully understood how the above relationships work. Moreover, factors such as long work shifts (<xref ref-type="bibr" rid="ref7">7</xref>), night shifts (<xref ref-type="bibr" rid="ref8">8</xref>), and emerging issues like stress, anxiety, and depression (<xref ref-type="bibr" rid="ref9">9</xref>) further exacerbate these challenges, casting a shadow over the well-being of medical students.</p>
<p>The goal of medical education is to develop doctors who are both healthy and competent so that they can better serve the community (<xref ref-type="bibr" rid="ref10">10</xref>). However, in recent decades, the medical profession has faced heightened scrutiny and criticism for both perceived and actual violations of professional behavior. Numerous studies have been conducted on unprofessional conduct among trainee doctors. Research by Resnick et al. (<xref ref-type="bibr" rid="ref59">59</xref>) found that professional misconduct is common among US general surgery residents and can lead to their dismissal from the training program. The challenges associated with unprofessional behavior do not arise solely after one qualifies as a physician. Research and medical authorities indicate that the issues often stem from the early years of medical training. The General Medical Council underscores the importance of fostering professional behaviors in medical students starting from their initial undergraduate years (<xref ref-type="bibr" rid="ref60">60</xref>). There are growing concerns about the decline in professionalism among students (<xref ref-type="bibr" rid="ref61">61</xref>) and its links to reduced job performance and burnout (<xref ref-type="bibr" rid="ref62">62</xref>). The significance of medical professionalism is gaining renewed attention among healthcare professionals and society to address these concerns and enhance awareness of the social responsibilities of medicine. Additionally, it has become increasingly recognized and accepted in recent years that the most effective approach is to realign medical education and practice with its fundamental values of professionalism (<xref ref-type="bibr" rid="ref63">63</xref>). It is, therefore, essential to enhance students&#x2019; learning around the attributes of medical professionalism during undergraduate medical education (<xref ref-type="bibr" rid="ref64">64</xref>). However, a concerning trend of declining professionalism attributes among medical students during their training poses a significant threat to professionalism and, consequently, patient care quality (<xref ref-type="bibr" rid="ref11">11</xref>). The scope of medical professionalism differs throughout the world with different cultural contexts (<xref ref-type="bibr" rid="ref12">12</xref>) but typically includes values such as altruism, accountability, and a commitment to excellence, as recognized by organizations like the American Board of Internal Medicine (<xref ref-type="bibr" rid="ref13">13</xref>). Recognizing the pivotal role that medical students play in shaping the future of healthcare systems, it becomes imperative to address issues related to mental well-being, including burnout and psychological distress, to ensure the cultivation of empathetic and ethical healthcare professionals (<xref ref-type="bibr" rid="ref3">3</xref>, <xref ref-type="bibr" rid="ref4">4</xref>).</p>
<p>Coping refers to the mental, emotional, and behavioral efforts made to manage a challenging relationship between an individual and their environment (<xref ref-type="bibr" rid="ref14">14</xref>). Research has shown that both individual characteristics and situational factors can affect coping. In a review, Skinner et al. (<xref ref-type="bibr" rid="ref15">15</xref>) noted that while hundreds of coping strategies are currently under evaluation, these strategies generally fall into five primary categories: problem-solving, support-seeking, avoidance, diversion, and positive cognitive restructuring.</p>
<p>At the undergraduate level, utilisation of coping strategies (CSs) for discrete mindfulness and the level of medical students&#x2019; mental well-being might play a crucial role in leading them towards medical professionalism attributes or even an unprofessional act (i.e., professionalism laps). There is a global trend in the use of both positive and negative coping strategies (NCSs). Problem-focused coping seeks to reduce or eliminate the source of stress, while emotion-focused coping changes the way an individual responds to stressors.</p>
<p>Literature suggests that CSs are vital for well-being (<xref ref-type="bibr" rid="ref16">16</xref>). According to Zajacova and Lynch (<xref ref-type="bibr" rid="ref17">17</xref>), stress is prevalent among students in academic settings. Therefore, a student&#x2019;s ability to choose and employ effective coping strategies (CS) to mitigate psychological distress is linked to their other personal resources (<xref ref-type="bibr" rid="ref18">18</xref>). Such situations highlight the necessity of developing a plan to identify the relationships between medical professionalism and mental well-being. This approach can assist medical educators in recognizing, exploring, and improving their strategies to address instances of unprofessional behavior among students (<xref ref-type="bibr" rid="ref19">19</xref>).</p>
<p>Identifying these interrelations will allow medical educators to positively influence students&#x2019; professional behavior, enhancing their understanding of professionalism. This, in turn, will help achieve the fundamental goal of medical education: producing &#x201C;well-being doctors&#x201D; capable of addressing the needs of patients and the community.</p>
<p>As depicted in <xref ref-type="fig" rid="fig1">Figure 1</xref>, the existing literature reveals a scarcity of evidence regarding the impact of mental well-being issues on the professionalism of medical students. Current reports fail to adequately explore the causal relationships between these two critical domains: mental well-being and medical professionalism. Additionally, there is a notable gap in our understanding of the role of coping mechanisms as a mediator in the relationship between mental well-being indicators (including stress, anxiety, depression, and burnout) and attributes of medical professionalism (such as professional behavior and empathy).</p>
<fig position="float" id="fig1">
<label>Figure 1</label>
<caption>
<p>Theoretical framework.</p>
</caption>
<graphic xlink:href="fmed-11-1468654-g001.tif"/>
</fig>
<p>Despite the paramount importance of understanding the intricate relationship between coping strategies (CSs), mental well-being, and medical professionalism among medical students, this area remains relatively unexplored in the existing literature. Exploring these interconnections holds significant promise for unravelling the complex dynamics that influence individual health, interpersonal relationships, and ultimately, the quality of patient care (<xref ref-type="bibr" rid="ref5">5</xref>, <xref ref-type="bibr" rid="ref6">6</xref>). By investigating these relationships, researchers can shed light on how the structure and content of medical education programs impact student well-being and medical professionalism, paving the way for targeted interventions and improvements in medical training practices.</p>
<p>The objective of our study is to examine the causal-effect relationship of medical professionalism, CSs, and mental well-being issues using structural equation modeling. Therefore, the relevant research question we have; what is the relationship amid medical professionalism, mental well-being and coping strategies among healthcare professionals?</p>
<p>We have formulated the following hypotheses aligning with our objective to examine the causal-effect relationships using structural equation modeling (SEM). These shall guide the analysis of the relationships between medical professionalism, coping strategies, and mental well-being.</p>
<disp-quote>
<p><italic>Hypothesis 1 (H1)</italic>. Higher levels of medical professionalism are associated with better mental well-being among healthcare professionals.</p>
</disp-quote>
<disp-quote>
<p><italic>Hypothesis 2 (H2)</italic>. Mental wellbeing issues negatively influence medical professionalism.</p>
</disp-quote>
<disp-quote>
<p><italic>Hypothesis 3 (H3)</italic>. Mental well-being issues hinder usage of positive coping.</p>
</disp-quote>
<disp-quote>
<p><italic>Hypothesis 4 (H4)</italic>. Mental well-being issues are associated with negative coping.</p>
</disp-quote>
</sec>
<sec sec-type="methods" id="sec6">
<title>Methodology</title>
<sec id="sec7">
<title>Study design</title>
<p>Authors selected quantitative correlational study design for this study as it allows for the rigorous examination of causal relationships and complex interactions among variables, providing valuable insights that can inform practice and policy.</p>
</sec>
<sec id="sec8">
<title>Setting</title>
<p>The medical curriculum at Universiti Sains Malaysia follows the student-centered, problem-based learning, integrated teaching, community-based, electives and systematic (SPICES) educational model, spanning 5&#x2009;years with pre-clinical and clinical phases. The pre-clinical years focus on fundamental biology and early clinical exposure, while the clinical phase emphasizes practical skills in real healthcare settings. This study was conducted using Google Forms, offering accessibility, cost-effectiveness, time efficiency, and scalability in data collection, aligning with modern research practices.</p>
</sec>
<sec id="sec9">
<title>Participants</title>
<p>Data were collected using five survey questionnaires from 234 subjects. Kline (<xref ref-type="bibr" rid="ref65">65</xref>) suggests a minimum sample size of 200 subjects for structural equation modeling (SEM) analysis. Factoring in a 30% non-response rate, the estimated sample size required for this study was 323 medical students.</p>
<p>At the beginning, we distributed the questionnaires to all undergraduate medical students studying in the years 1, 3 and 5 at Universiti Sains Malaysia, Health Campus, Kelantan. After the formal announcements (through student class leaders), the online link for the survey was sent to only those who showed their willingness by replying through emails or WhatsApp messages. They were from diverse levels of study (years 1, 3, and 5). The class leaders&#x2019; announcements for the research were made so that the interested student may contact the concerned person who shall discuss with students all the details about the research surveys (e.g., consent, time, date, venue, duration, potential benefits, and potential risks).</p>
</sec>
<sec id="sec10">
<title>Data collection</title>
<p>The primary data for structural equation modeling (SEM) came from responses gathered via five survey questionnaires in a cross-sectional study. A purposive sampling method was applied to 234 medical students across the 1st, 3rd, and 5th years at Universiti Sains Malaysia&#x2019;s Health Campus in Kelantan. The purpose of collecting data from medical students in their first, third, and fifth years was to expect a variety of responses and to learn about and collect a variety of factual situations and life experiences experienced by medical students at different phases about CSs, mental well-being issues (MWBi), and medical professionalism, throughout their undergraduate medical career. During the cross-sectional study, we investigated the level of mental well-being (burnout, anxiety, depression, stress) CSs, and medical professionalism attributes at a single time frame (October 2022&#x2013;November 2022) using validated instruments listed with their respective determinants in <xref ref-type="table" rid="tab1">Table 1</xref>.</p>
<table-wrap position="float" id="tab1">
<label>Table 1</label>
<caption>
<p>Five survey questionnaires with respective determinants.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Questionnaire</th>
<th align="left" valign="top">Determinants</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Dundee Polyprofessionalism Inventory I: Academic Integrity (Dundee Inventory)</td>
<td align="left" valign="top">Professional behavior score</td>
</tr>
<tr>
<td align="left" valign="top">Depression, Anxiety, and Stress Scales DASS-9</td>
<td align="left" valign="top">Depression, anxiety, &#x0026; stress score</td>
</tr>
<tr>
<td align="left" valign="top">Brief COPE</td>
<td align="left" valign="top">Coping score</td>
</tr>
<tr>
<td align="left" valign="top">Copenhagen Burnout Inventory</td>
<td align="left" valign="top">Burnout score</td>
</tr>
<tr>
<td align="left" valign="top">Toronto Empathy Questionnaire</td>
<td align="left" valign="top">Empathy score</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>All the survey questionnaires are included in <xref ref-type="supplementary-material" rid="SM1">Appendix N</xref>. DASS-9, Depression, Anxiety and Stress Scale; Brief COPE, Brief Coping Orientation to Problems Experienced; CBI, Copenhagen Burnout Inventory; TEQ, Toronto Empathy Questionnaire.</p>
</table-wrap-foot>
</table-wrap>
<p>A detailed meeting among the research team was held to finalize the inventories, a consensus was achieved on the list of instruments, and later in a subsequent meeting, an agreement was sought on selecting items from the selected inventories to be utilized. The criteria for selecting or omitting items from the selected inventories were based on our objectives. Two inventories, i.e., Distress Anxiety Stress Scale-9 (DASS-9) and Toronto Empathy Questionnaire (TEQ) were selected to be used as it is, whereas three inventories, i.e., Dundee, Brief Coping Orientation to Problems Experienced (COPE), and Copenhagen Burnout Inventory (CBI) were used with reduced items to best match our objectives. For the Dundee inventory, we selected eight items (from a total of 34), Brief COPE; 12 items (from a total of 28), and CBI; 13 items (from a total of 19).</p>
<p>As mentioned earlier, to best depict the construct of interest, from Dundee inventory, we selected and utilized eight types of professionalism lapse items. The Dundee inventory (Poly-professionalism Inventory I: Academic Integrity), developed and validated by Roff et al. (<xref ref-type="bibr" rid="ref20">20</xref>, <xref ref-type="bibr" rid="ref21">21</xref>), has been frequently used as customized (<xref ref-type="bibr" rid="ref22">22</xref>, <xref ref-type="bibr" rid="ref23">23</xref>). The author of the brief COPE inventory, Charles S. Carver has allowed to use this inventory as complete or any scales relevant to the researchers&#x2019; needs. Brambila-Tapia et al. (<xref ref-type="bibr" rid="ref24">24</xref>) used reduced items (<xref ref-type="bibr" rid="ref14">14</xref>) for their study. We also performed an item reduction for Brief COPE, leaving only the most representative subscales for positive (adaptive) and negative (maladaptive) coping. This way, we were able to have 6 items relevant to each (positive and negative) coping strategy. Concerning CBI, out of the 19, we identified and used 13 survey items to best represent the constructs of interest. It&#x2019;s a practice of researchers to carefully select which type of burnout among the three (personal, work, and client-related) to be selected, as Huang et al. (<xref ref-type="bibr" rid="ref25">25</xref>) did not measure work-related burnout but only personal-related and patient-related. Considering our research needs, we also did not measure client-related burnout as it did not match our research objectives.</p>
<p>A summary detailing the item distribution, with response categories and score interpretation, is available (<xref ref-type="table" rid="tab2">Table 2</xref>). Five inventories with the final items are mentioned in <xref ref-type="supplementary-material" rid="SM1">Appendix N</xref>. Furthermore, we evaluated model fit using established indices (<xref ref-type="table" rid="tab3">Table 3</xref>) supported by widespread literature.</p>
<table-wrap position="float" id="tab2">
<label>Table 2</label>
<caption>
<p>Detailed summary of validated study instruments.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Instrument</th>
<th align="left" valign="top">Domains</th>
<th align="center" valign="top">No. of items</th>
<th align="left" valign="top">Response categories</th>
<th align="left" valign="top">Score interpretation</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">Dundee Inventory</td>
<td align="left" valign="top">Unprofessional behavior</td>
<td align="center" valign="top">8</td>
<td align="left" valign="top">&#x201C;1. Ignore (None)&#x201D;<break/>&#x201C;2. Reprimand (verbal warning)&#x201D;<break/>&#x201C;3. Reprimand (written warning)&#x201D;<break/>&#x201C;4. Reprimand, plus mandatory counseling&#x201D;<break/>&#x201C;5. Reprimand, counseling, extra work assignment&#x201D;<break/>&#x201C;6. Failure of specific class/remedial work to gain credit&#x201D;<break/>&#x201C;7. Failure of a specific year (repetition allowed)&#x201D;<break/>&#x201C;8. Expulsion from college (readmission after one year possible)&#x201D;<break/>&#x201C;9. Expulsion from college (no chance for readmission)&#x201D;<break/>&#x201C;10. Report to a regulatory body&#x201D;</td>
<td align="left" valign="top">Mean and SD</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="3">Depression, Anxiety and Stress Scale (DASS-9)</td>
<td align="left" valign="top">Depression</td>
<td align="center" valign="top">3</td>
<td align="left" valign="top" rowspan="3">&#x201C;0&#x2014;Did not apply to me at all&#x201D;<break/>&#x201C;1&#x2014;Applied to me to some degree, or some of the time&#x201D;<break/>&#x201C;2&#x2014;Applied to me to a considerable degree or a good part of the time&#x201D;<break/>&#x201C;3&#x2014;Applied to me very much, or most of the time&#x201D;</td>
<td align="left" valign="top" rowspan="3">Normal scores were treated as negative screening, and mild to extremely severe were treated as positive screening</td>
</tr>
<tr>
<td align="left" valign="top">Anxiety</td>
<td align="center" valign="top">3</td>
</tr>
<tr>
<td align="left" valign="top">Stress</td>
<td align="center" valign="top">3</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="6">Brief Coping Orientation to Problem Experienced (Brief COPE)</td>
<td align="left" valign="top">Denial</td>
<td align="center" valign="top">2</td>
<td align="left" valign="top" rowspan="6">&#x201C;1&#x2014;I have not been doing this at all&#x201D;<break/>&#x201C;2&#x2014;I have been doing this a little bit&#x201D;<break/>&#x201C;3&#x2014;I have been doing this a medium amount&#x201D;<break/>&#x201C;4&#x2014;I have been doing this a lot&#x201D;</td>
<td align="left" valign="top" rowspan="6">Mean and SD</td>
</tr>
<tr>
<td align="left" valign="top">Substance use</td>
<td align="center" valign="top">2</td>
</tr>
<tr>
<td align="left" valign="top">Support-emotional</td>
<td align="center" valign="top">2</td>
</tr>
<tr>
<td align="left" valign="top">Self-blame</td>
<td align="center" valign="top">2</td>
</tr>
<tr>
<td align="left" valign="top">Religion</td>
<td align="center" valign="top">2</td>
</tr>
<tr>
<td align="left" valign="top">Acceptance</td>
<td align="center" valign="top">2</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="2">Copenhagen Burnout Inventory (CBI)</td>
<td align="left" valign="top">Personal-related</td>
<td align="center" valign="top">6</td>
<td align="left" valign="top" rowspan="2">&#x201C;100&#x2014;Always/To a very high degree&#x201D;<break/>&#x201C;75&#x2014;Often/To a high degree&#x201D;<break/>&#x201C;50&#x2014;Sometimes/Somewhat&#x201D;<break/>&#x201C;25&#x2014;Seldom/To a low degree&#x201D;<break/>&#x201C;0&#x2014;Never/Almost never/To a very low degree&#x201D;</td>
<td align="left" valign="top" rowspan="2">Average scores were calculated for each domain<break/>An average score of 50 or above is treated as burnout</td>
</tr>
<tr>
<td align="left" valign="top">Work-related</td>
<td align="center" valign="top">7</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="2">Toronto Empathy Questionnaire (TEQ)</td>
<td align="left" valign="top">Empathy-positive worded items</td>
<td align="center" valign="top">8</td>
<td align="left" valign="top" rowspan="2">&#x201C;Never&#x2009;=&#x2009;0&#x201D;<break/>&#x201C;Rarely&#x2009;=&#x2009;1; Sometimes&#x2009;=&#x2009;2&#x201D;<break/>&#x201C;Often&#x2009;=&#x2009;3&#x201D;<break/>&#x201C;Always&#x2009;=&#x2009;4&#x201D;</td>
<td align="left" valign="top" rowspan="2">Sores are summed to derive the total for the Toronto Empathy Questionnaire, which can range from 0 to 64</td>
</tr>
<tr>
<td align="left" valign="top">Empathy-negative worded items</td>
<td align="center" valign="top">8</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap position="float" id="tab3">
<label>Table 3</label>
<caption>
<p>Various fit indices with levels of acceptance.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Name of category</th>
<th align="left" valign="top">Name of index</th>
<th align="left" valign="top">Level of acceptance</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top" rowspan="2">Absolute fit</td>
<td align="left" valign="top">&#x201C;Root mean square for error approximation&#x201D; (RMSEA)</td>
<td align="left" valign="top">&#x003C;0.08 (<xref ref-type="bibr" rid="ref69">69</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">&#x201C;Goodness of fit index&#x201D; (GFI)</td>
<td align="left" valign="top">&#x003E;0.9 (<xref ref-type="bibr" rid="ref70">70</xref>)</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="3">Incremental fit</td>
<td align="left" valign="top">&#x201C;Comparative fit index&#x201D; (CFI)</td>
<td align="left" valign="top">&#x003E;0.9 (<xref ref-type="bibr" rid="ref71">71</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">&#x201C;Tucker&#x2013;Lewis index&#x201D; (TLI)</td>
<td align="left" valign="top">&#x003E;0.9 (<xref ref-type="bibr" rid="ref72">72</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">&#x201C;Normed fit index&#x201D; (NFI)</td>
<td align="left" valign="top">&#x003E;0.9 (<xref ref-type="bibr" rid="ref73">73</xref>)</td>
</tr>
<tr>
<td align="left" valign="top">Parsimonious fit</td>
<td align="left" valign="top">&#x201C;Chi-square/degree of freedom&#x201D; (v2/df)</td>
<td align="left" valign="top">&#x003C;5 (<xref ref-type="bibr" rid="ref74">74</xref>)</td>
</tr>
</tbody>
</table>
</table-wrap>
<p>Since, the SEM utilized the maximum likelihood (ML) method, known for its asymptotically unbiased and efficient estimator (<xref ref-type="bibr" rid="ref26">26</xref>), it helped us prioritize minimizing bias in the analysis process to ensure accurate results.</p>
</sec>
<sec id="sec11">
<title>Statistical method</title>
<p>Using SPSS version 20, we conducted a descriptive analysis of demographic information. Samples having full responses to all inventories underwent SEM analysis using Analysis of Moment Structure (AMOS 29). We utilized five validated scales to meet research needs and conducted confirmatory factor analysis (CFA) to test measurement model fit for each construct.</p>
</sec>
<sec id="sec12">
<title>Measurement model</title>
<p>CFA delineated observed variables for latent constructs and model fit was assessed for all items across five inventories. Composite reliability (CR) was calculated using Microsoft<sup>&#x00AE;</sup> Excel<sup>&#x00AE;</sup> with the following formula;</p>
<disp-formula id="E1">
<mml:math id="M1">
<mml:mfrac>
<mml:msup>
<mml:mfenced open="(" close=")">
<mml:mrow>
<mml:mo stretchy="true">&#x2211;</mml:mo>
<mml:mrow>
<mml:msub>
<mml:mi>&#x03BB;</mml:mi>
<mml:mi>i</mml:mi>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:mfenced>
<mml:mn>2</mml:mn>
</mml:msup>
<mml:mrow>
<mml:msup>
<mml:mfenced open="(" close=")">
<mml:mrow>
<mml:mo stretchy="true">&#x2211;</mml:mo>
<mml:mrow>
<mml:msub>
<mml:mi>&#x03BB;</mml:mi>
<mml:mi>i</mml:mi>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:mfenced>
<mml:mn>2</mml:mn>
</mml:msup>
<mml:mo>+</mml:mo>
<mml:mo stretchy="true">&#x2211;</mml:mo>
<mml:mrow>
<mml:msub>
<mml:mi>&#x03B5;</mml:mi>
<mml:mi>i</mml:mi>
</mml:msub>
</mml:mrow>
</mml:mrow>
</mml:mfrac>
</mml:math>
</disp-formula>
<p>whereby <italic>&#x03BB;</italic> (lambda) is the standardized factor loading for item <italic>i</italic> and <italic>&#x03B5;</italic> is the respective error variance for item <italic>i</italic>. The error variance <italic>&#x03B5;</italic> is estimated based on the value of the standardized loading (<italic>&#x03BB;</italic>) as <italic>&#x03B5;<sub>i</sub></italic>&#x2009;=&#x2009;1&#x2009;&#x2212;&#x2009;<italic>&#x03BB;</italic><sup>2</sup><italic><sub>i</sub></italic>.</p>
</sec>
<sec id="sec13">
<title>Steps of SEM analysis</title>
<p>The researcher prioritized minimizing bias in the analysis process to ensure accurate results. SEM utilized the maximum likelihood (ML) method, known for its asymptotically unbiased and efficient estimator (<xref ref-type="bibr" rid="ref26">26</xref>). Moreover, we followed five logical steps in SEM: (1) model specification, (2) identification, (3) parameter estimation, (4) model evaluation, and (5) model modification (<xref ref-type="bibr" rid="ref66 ref67 ref68">66&#x2013;68</xref>). Our study aimed to identify causal relationships between medical professionalism and mental well-being, ensuring association, time order, and non-spuriousness. Association between variables, indicating correlation, was a starting point for establishing causality, emphasizing statistical significance. Time order was crucial; the cause must precede the effect logically. Non-spurious relationships were sought through study design and meticulous data collection. In SEM, path analysis diagrams were created, and analyses were conducted following AMOS guidelines. Standardized estimates were utilized for their consistency across variables with different measurement scales. This approach allowed the comparison of exogenous variables&#x2019; (with no arrows pointing to, are exogenous variables) effects on endogenous variables (the variables to which arrows point are endogenous), facilitating the recognition of causal relationships.</p>
</sec>
</sec>
<sec sec-type="results" id="sec14">
<title>Results</title>
<sec id="sec15">
<title>Demographic data</title>
<p>Survey questionnaires were distributed to a total of 800 students and 234 students participated, including 95 (40.6%) from the first, 41 (17.55) third, and 98 (41.9) fifth year of the medical course. Participants were primarily female (78.2%), the overriding race was Malaysian (76.9%), and the majority (41.9%) were from the fifth year of study. The demographic distribution is highlighted in <xref ref-type="table" rid="tab4">Table 4</xref>.</p>
<table-wrap position="float" id="tab4">
<label>Table 4</label>
<caption>
<p>Demographics of the study participants (<italic>n</italic>&#x2009;=&#x2009;234) for surveys.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Demographic characteristics (<italic>n</italic>&#x2009;=&#x2009;234)</th>
<th align="center" valign="top"><italic>n</italic> (%)</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top" colspan="2">Medical course</td>
</tr>
<tr>
<td align="left" valign="top">1<sup>st</sup> year</td>
<td align="char" valign="top" char="(">95 (40.6)</td>
</tr>
<tr>
<td align="left" valign="top">3<sup>rd</sup> year</td>
<td align="char" valign="top" char="(">41 (17.5)</td>
</tr>
<tr>
<td align="left" valign="top">5<sup>th</sup> year</td>
<td align="char" valign="top" char="(">98 (41.9)</td>
</tr>
<tr>
<td align="left" valign="top" colspan="2">Personal demographics</td>
</tr>
<tr>
<td align="left" valign="top" colspan="2">Gender</td>
</tr>
<tr>
<td align="left" valign="top">Male</td>
<td align="char" valign="top" char="(">49 (20.9)</td>
</tr>
<tr>
<td align="left" valign="top">Female</td>
<td align="char" valign="top" char="(">183 (78.2)</td>
</tr>
<tr>
<td align="left" valign="top">Prefer not to say</td>
<td align="char" valign="top" char="(">2 (0.9)</td>
</tr>
<tr>
<td align="left" valign="top" colspan="2">Race</td>
</tr>
<tr>
<td align="left" valign="top">Malay</td>
<td align="char" valign="top" char="(">180 (76.9)</td>
</tr>
<tr>
<td align="left" valign="top">Indian</td>
<td align="char" valign="top" char="(">26 (11.1)</td>
</tr>
<tr>
<td align="left" valign="top">Chinese</td>
<td align="char" valign="top" char="(">22 (9.4)</td>
</tr>
<tr>
<td align="left" valign="top">Other</td>
<td align="char" valign="top" char="(">6 (2.5)</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
<sec id="sec16">
<title>Measurement and structural model findings</title>
<p><xref ref-type="table" rid="tab5">Table 5</xref> shows the CFA findings and helped to assess model fit with measurement models of professional behavior (<xref ref-type="supplementary-material" rid="SM1">Appendix B</xref>) and mental well-being (<xref ref-type="supplementary-material" rid="SM1">Appendix C</xref>). Similarly, <xref ref-type="supplementary-material" rid="SM1">Appendix D</xref> depicts a model for positive coping strategies (PCS) which was evaluated using six items. However, initial attempts to model negative coping strategies (NCS1) were unsuccessful due to poor factor loading of two items (<xref ref-type="supplementary-material" rid="SM1">Appendix E</xref>), which were subsequently removed. The revised model (NCS2) with four items (<xref ref-type="supplementary-material" rid="SM1">Appendix F</xref>) demonstrated acceptable fit indices (<xref ref-type="table" rid="tab3">Table 3</xref>). Moreover, the burnout model (<xref ref-type="supplementary-material" rid="SM1">Appendix G</xref>) comprised 13 items and achieved a satisfactory model fit. Likewise, empathy (<xref ref-type="supplementary-material" rid="SM1">Appendix H</xref>) with 16 items attained model fit.</p>
<table-wrap position="float" id="tab5">
<label>Table 5</label>
<caption>
<p>Results of CFA for all inventories (the measurement model of constructs).</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top" colspan="2" rowspan="2">Inventories</th>
<th align="left" valign="top" rowspan="2">Determinants</th>
<th align="center" valign="top" colspan="6">CFA parameters obtained</th>
</tr>
<tr>
<th align="center" valign="top"><italic>&#x03C7;</italic><sup>2</sup>/df=</th>
<th align="center" valign="top">
<italic>p</italic>
</th>
<th align="center" valign="top">TLI</th>
<th align="center" valign="top">CFI</th>
<th align="center" valign="top">RMSEA</th>
<th align="center" valign="top">CR</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top" colspan="2">Polyprofessionalism</td>
<td align="left" valign="top">Professional behavior</td>
<td align="char" valign="top" char=".">1.005</td>
<td align="char" valign="top" char=".">0.441</td>
<td align="char" valign="top" char=".">1.000</td>
<td align="char" valign="top" char=".">1.000</td>
<td align="char" valign="top" char=".">0.005</td>
<td align="char" valign="top" char=".">0.765</td>
</tr>
<tr>
<td align="left" valign="top" colspan="2">DASS-9</td>
<td align="left" valign="top">Depression, anxiety, and stress</td>
<td align="char" valign="top" char=".">1.127</td>
<td align="char" valign="top" char=".">0.319</td>
<td align="char" valign="top" char=".">0.992</td>
<td align="char" valign="top" char=".">0.996</td>
<td align="char" valign="top" char=".">0.023</td>
<td align="char" valign="top" char=".">0.830</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="2">Brief COPE</td>
<td align="left" valign="top"><sup>&#x002A;</sup>NCS2</td>
<td align="left" valign="top">Negative coping strategies (4 items)</td>
<td align="char" valign="top" char=".">3.681</td>
<td align="char" valign="top" char=".">0.055</td>
<td align="char" valign="top" char=".">0.948</td>
<td align="char" valign="top" char=".">0.991</td>
<td align="char" valign="top" char=".">0.107</td>
<td align="char" valign="top" char="." rowspan="2">0.596</td>
</tr>
<tr>
<td align="left" valign="top"><sup>&#x002A;&#x002A;</sup>PCS</td>
<td align="left" valign="top">Positive coping strategies (6 items)</td>
<td align="char" valign="top" char=".">1.352</td>
<td align="char" valign="top" char=".">0.221</td>
<td align="char" valign="top" char=".">0.991</td>
<td align="char" valign="top" char=".">0.996</td>
<td align="char" valign="top" char=".">0.039</td>
</tr>
<tr>
<td align="left" valign="top" colspan="2">CBI</td>
<td align="left" valign="top">Burnout</td>
<td align="char" valign="top" char=".">1.020</td>
<td align="char" valign="top" char=".">0.434</td>
<td align="char" valign="top" char=".">0.999</td>
<td align="char" valign="top" char=".">1.000</td>
<td align="char" valign="top" char=".">0.009</td>
<td align="char" valign="top" char=".">0.928</td>
</tr>
<tr>
<td align="left" valign="top" colspan="2">TEQ</td>
<td align="left" valign="top">Empathy</td>
<td align="char" valign="top" char=".">0.820</td>
<td align="char" valign="top" char=".">0.855</td>
<td align="char" valign="top" char=".">1.000</td>
<td align="char" valign="top" char=".">1.000</td>
<td align="char" valign="top" char=".">&#x003C;0.001</td>
<td align="char" valign="top" char=".">0.138</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>Depression, Anxiety and Stress Scale (DASS-9), <sup>&#x002A;</sup>Negative Coping Strategies (NCS), <sup>&#x002A;&#x002A;</sup>Positive Coping Strategies (PCS); taken from Brief Coping Orientation to Problems Experienced (Brief COPE), Copenhagen Burnout Inventory (CBI), Toronto Empathy Questionnaire (TEQ). Chi-square (<italic>&#x03C7;</italic><sup>2</sup>), Degree of freedom (df), <italic>p</italic>-value (<italic>p</italic>), Tucker&#x2013;Lewis index (TLI), Comparative fit index (CFI), Root mean square error of approximation (RMSEA), Composite reliability (CR).</p>
</table-wrap-foot>
</table-wrap>
<p><xref ref-type="supplementary-material" rid="SM1">Appendix I</xref> depicts the results of each latent construct with relevant manifest constructs.</p>
<p>During SEM, the Variable terms used for our structural models with respective intended concepts are enlisted in <xref ref-type="table" rid="tab6">Table 6</xref>. Results of the goodness of fit indices for the mental well-being (MWB) and medical professionalism (MP) relationship, with mediating effects of CSs (positive and negative), are summarized in <xref ref-type="table" rid="tab7">Table 7</xref>.</p>
<table-wrap position="float" id="tab6">
<label>Table 6</label>
<caption>
<p>Variables terms used for our SEM models with respective intended concepts.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Variable terms</th>
<th align="left" valign="top">Intended concepts</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top">PDScore</td>
<td align="left" valign="top">Psychological distress</td>
</tr>
<tr>
<td align="left" valign="top">BurnoutScore</td>
<td align="left" valign="top">Burnout</td>
</tr>
<tr>
<td align="left" valign="top">TEQScore</td>
<td align="left" valign="top">Empathy</td>
</tr>
<tr>
<td align="left" valign="top">PolyScore</td>
<td align="left" valign="top">Professional behavior</td>
</tr>
<tr>
<td align="left" valign="top">PCS</td>
<td align="left" valign="top">Positive coping strategy</td>
</tr>
<tr>
<td align="left" valign="top">NCS</td>
<td align="left" valign="top">Negative coping strategy</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap position="float" id="tab7">
<label>Table 7</label>
<caption>
<p>The goodness of fit indices for supporting the best-fit model.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top" rowspan="2">Models</th>
<th align="center" valign="top" colspan="7">The goodness of fit indices</th>
</tr>
<tr>
<th align="center" valign="top"><italic>&#x03C7;</italic><sup>2</sup>/df</th>
<th align="center" valign="top"><italic>p</italic>-value</th>
<th align="center" valign="top">TLI</th>
<th align="center" valign="top">CFI</th>
<th align="center" valign="top">RMSEA</th>
<th align="center" valign="top">GFI</th>
<th align="center" valign="top">NFI</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle">Model 1 (MWBi-MP)</td>
<td align="char" valign="middle" char=".">10.549</td>
<td align="char" valign="middle" char=".">0.001</td>
<td align="char" valign="middle" char=".">0.608</td>
<td align="char" valign="middle" char=".">0.935</td>
<td align="char" valign="middle" char=".">0.202</td>
<td align="char" valign="middle" char=".">0.979</td>
<td align="char" valign="middle" char=".">0.931</td>
</tr>
<tr>
<td align="left" valign="middle">Model 2 (modified MWBi-MP)</td>
<td align="char" valign="middle" char=".">1.459</td>
<td align="char" valign="middle" char=".">0.227</td>
<td align="char" valign="middle" char=".">0.981</td>
<td align="char" valign="middle" char=".">0.997</td>
<td align="char" valign="middle" char=".">0.044</td>
<td align="char" valign="middle" char=".">0.997</td>
<td align="char" valign="middle" char=".">0.990</td>
</tr>
<tr>
<td align="left" valign="middle">Model 3 (MWBI-PCS-MP)</td>
<td align="char" valign="middle" char=".">1.456</td>
<td align="char" valign="middle" char=".">0.045</td>
<td align="char" valign="middle" char=".">0.973</td>
<td align="char" valign="middle" char=".">0.982</td>
<td align="char" valign="middle" char=".">0.044</td>
<td align="char" valign="middle" char=".">0.965</td>
<td align="char" valign="middle" char=".">0.947</td>
</tr>
<tr>
<td align="left" valign="middle">Model 4 (MWBi-NCS-MP)</td>
<td align="char" valign="middle" char=".">2.193</td>
<td align="char" valign="middle" char=".">0.000</td>
<td align="char" valign="middle" char=".">0.946</td>
<td align="char" valign="middle" char=".">0.966</td>
<td align="char" valign="middle" char=".">0.072</td>
<td align="char" valign="middle" char=".">0.949</td>
<td align="char" valign="middle" char=".">0.941</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>Chi-square (<italic>&#x03C7;</italic><sup>2</sup>), Degree of freedom (df), <italic>p</italic>-value (<italic>p</italic>), Tucker&#x2013;Lewis index (TLI), Comparative fit index (CFI), Root mean square error of approximation (RMSEA), Goodness of fit index (GFI), Normed fit index (NFI).</p>
</table-wrap-foot>
</table-wrap>
<p>Our study revealed that initial Model 1 (<xref ref-type="fig" rid="fig2">Figure 2</xref>), examining causal-effect relationships, did not fit well despite good GFI (0.979) and acceptable CFI (0.935). Model modification improved fit to create Model 2.</p>
<fig position="float" id="fig2">
<label>Figure 2</label>
<caption>
<p>The causal-effect relationship between mental well-being issues and medical professionalism (Model 1: MWBi-MP).</p>
</caption>
<graphic xlink:href="fmed-11-1468654-g002.tif"/>
</fig>
<p><xref ref-type="fig" rid="fig3">Figure 3</xref> shows Model 2 which exhibited better-fit indices: Chi-square/df&#x2009;=&#x2009;1.459, TLI&#x2009;=&#x2009;0.981, CFI&#x2009;=&#x2009;0.997, RMSEA&#x2009;=&#x2009;0.044, GFI&#x2009;=&#x2009;0.997, NFI&#x2009;=&#x2009;0.990 (<xref ref-type="table" rid="tab7">Table 7</xref>). No post-hoc modifications were needed due to the good fit index. Furthermore, Model 2&#x2019;s direct, indirect, and total effects on the model paths are presented in <xref ref-type="table" rid="tab8">Tables 8</xref>, <xref ref-type="table" rid="tab9">9</xref>.</p>
<fig position="float" id="fig3">
<label>Figure 3</label>
<caption>
<p>The modified causal-effect relationship between mental well-being issues and medical professionalism (Model 2: modified MWBi-MP).</p>
</caption>
<graphic xlink:href="fmed-11-1468654-g003.tif"/>
</fig>
<table-wrap position="float" id="tab8">
<label>Table 8</label>
<caption>
<p>The estimates of standardized and unstandardized regression weights of variables for Model 2.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top" colspan="2">Observed variables</th>
<th align="center" valign="top">
<italic>&#x03B2;</italic>
</th>
<th align="center" valign="top">
<italic>B</italic>
</th>
<th align="center" valign="top">SE</th>
<th align="center" valign="top"><italic>p</italic>-values</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle" rowspan="2">Professional behavior (PolyScore)</td>
<td align="left" valign="middle">Psychological Distress (PDScore)</td>
<td align="char" valign="top" char=".">&#x2212;0.059</td>
<td align="char" valign="top" char=".">&#x2212;0.025</td>
<td align="char" valign="top" char=".">0.028</td>
<td align="char" valign="top" char=".">0.371</td>
</tr>
<tr>
<td align="left" valign="middle">Burnout (BurnoutScore)</td>
<td align="char" valign="top" char=".">&#x2212;0.306</td>
<td align="char" valign="top" char=".">&#x2212;0.268</td>
<td align="char" valign="top" char=".">0.043</td>
<td align="char" valign="top" char=".">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="middle" rowspan="2">Psychological distress (PDScore)</td>
<td align="left" valign="middle">Burnout (BurnoutScore)</td>
<td align="char" valign="top" char=".">0.567</td>
<td align="char" valign="top" char=".">1.174</td>
<td align="char" valign="top" char=".">0.102</td>
<td align="char" valign="top" char=".">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="middle">Empathy (TEQScore)</td>
<td align="char" valign="top" char=".">&#x2212;0.159</td>
<td align="char" valign="top" char=".">&#x2212;0.254</td>
<td align="char" valign="top" char=".">0.125</td>
<td align="char" valign="top" char=".">0.042</td>
</tr>
<tr>
<td align="left" valign="middle">Burnout (BurnoutScore)</td>
<td align="left" valign="middle">Empathy (TEQScore)</td>
<td align="char" valign="top" char=".">&#x2212;0.136</td>
<td align="char" valign="top" char=".">&#x2212;0.105</td>
<td align="char" valign="top" char=".">0.060</td>
<td align="char" valign="top" char=".">0.082</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>
<italic>&#x03B2;&#x2009;=&#x2009;standardized regression weights; B&#x2009;=&#x2009;unstandardized regression weights; SE&#x2009;=&#x2009;standard error.</italic>
</p>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="tab9">
<label>Table 9</label>
<caption>
<p>The unstandardized and standardized estimates of direct, indirect, and total effects for variables relationships for Model 2.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Parameter</th>
<th align="center" valign="top" colspan="2">Variables relationship</th>
<th align="center" valign="top">Total (95% CI)</th>
<th align="center" valign="top">Direct (95% CI)</th>
<th align="center" valign="top">Indirect (95% CI)</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top" rowspan="6">Unstandardized</td>
<td align="left" valign="top">PolyScore</td>
<td align="left" valign="top">PDScore</td>
<td align="char" valign="top" char="(">&#x2212;0.025 (&#x2212;0.078, 0.034)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.025 (&#x2212;0.078, 0.034)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
<tr>
<td align="left" valign="top">PolyScore</td>
<td align="left" valign="top" rowspan="2">BurnoutScore</td>
<td align="char" valign="top" char="(">&#x2212;0.297 (&#x2212;0.407, &#x2212;0.176)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.268 (&#x2212;0.358, &#x2212;0.176)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.029 (&#x2212;0.089, 0.040)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">PDScore</td>
<td align="char" valign="top" char="(">1.174 (0.950, 1.384)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">1.174 (0.950, 1.384)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
<tr>
<td align="left" valign="top">PolyScore</td>
<td align="left" valign="top" rowspan="3">TEQScore</td>
<td align="char" valign="top" char="(">0.037 (0.001, 0.092)<sup>&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
<td align="center" valign="top">0.037 (0.001, 0.092)<sup>&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">PDScore</td>
<td align="char" valign="top" char="(">&#x2212;0.377 (&#x2212;0.578, &#x2212;0.177)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.254 (&#x2212;0.507, 0.013)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.123 (&#x2212;0.306. 0.037)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">BurnoutScore</td>
<td align="char" valign="top" char="(">&#x2212;0.105 (&#x2212;0.248, 0.032)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.105 (&#x2212;0.248, 0.032)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="6">Standardized</td>
<td align="left" valign="top">PolyScore</td>
<td align="left" valign="top">PDScore</td>
<td align="char" valign="top" char="(">&#x2212;0.059 (&#x2212;0.186, 0.076)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.059 (&#x2212;0.186, 0.076)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
<tr>
<td align="left" valign="top">PolyScore</td>
<td align="left" valign="top" rowspan="2">BurnoutScore</td>
<td align="char" valign="top" char="(">&#x2212;0.340 (&#x2212;0.466, &#x2212;0.200)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.306 (&#x2212;0.404, &#x2212;0.190)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.033 (&#x2212;0.101, 0.048)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">PDScore</td>
<td align="char" valign="top" char="(">0.567 (0.474, &#x2212;0.649)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">0.567 (0.474, 0.649)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
<tr>
<td align="left" valign="top">PolyScore</td>
<td align="left" valign="top" rowspan="3">TEQScore</td>
<td align="char" valign="top" char="(">0.055 (0.001, 0.130)<sup>&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
<td align="center" valign="top">0.055 (0.001, 0.130)<sup>&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">PDScore</td>
<td align="char" valign="top" char="(">&#x2212;0.236 (&#x2212;0.358, &#x2212;0.109)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.159 (&#x2212;0.313, 0.010)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.077 (&#x2212;0.181, 0.024)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">BurnoutScore</td>
<td align="char" valign="top" char="(">&#x2212;0.136 (&#x2212;0.309, 0.049)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.136 (&#x2212;0.309, 0.049)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>Bootstrap (1000) with 95% bias-corrected confidence interval: L&#x2009;=&#x2009;lower bound; U&#x2009;=&#x2009;upper bound; <sup>&#x002A;</sup><italic>p</italic>-value &#x003C;0.05; <sup>&#x002A;&#x002A;</sup><italic>p</italic>-value &#x003C;0.01; <sup>&#x002A;&#x002A;&#x002A;</sup><italic>p</italic>-value &#x003E;0.05.</p>
</table-wrap-foot>
</table-wrap>
<p>Our study revealed that psychological distress significantly reduced empathy levels in undergraduate medical students. Additionally, psychological distress significantly contributed to burnout (<italic>&#x03B2;</italic>&#x2009;=&#x2009;0.567, <italic>p</italic>-value &#x003C;0.001) in undergraduate medical students (<xref ref-type="table" rid="tab8">Table 8</xref>). This was in align with our predicted H2. Hypothesis (H1) predicted, and our study also revealed that there was a significant influence of professional behavior on burnout (<italic>&#x03B2;</italic>&#x2009;=&#x2009;&#x2212;0.306, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001). Additionally, professional behavior significantly affects empathy indirectly (<italic>&#x03B2;</italic>&#x2009;=&#x2009;0.055) as shown in <xref ref-type="table" rid="tab9">Table 9</xref>.</p>
<p>According to our results, Model 3 achieved acceptable fit indices (<xref ref-type="table" rid="tab7">Table 7</xref>) and underwent modifications based on AMOS recommendations to enhance theoretical coherence. Specifically, adjustments included covariances between indicators (BCOPE5 and BCOPE6) and (BCOPE11 and BCOPE12) for the latent variable PCS (<xref ref-type="fig" rid="fig4">Figure 4</xref>). The results of this model informed that psychological distress influenced the use of positive coping strategies. As predicted by H3, psychological distress acted as an inhibitor for positive coping strategies, mediating through burnout and significantly reducing their use (<italic>p</italic>&#x2009;&#x003C;&#x2009;0.05). This model also confirmed that positive coping strategies as contributing factors for empathy.</p>
<fig position="float" id="fig4">
<label>Figure 4</label>
<caption>
<p>The causal-effect relationship model among mental well-being issues, positive coping strategy, and medical professionalism (Model 3: MWBi-PCS-MP).</p>
</caption>
<graphic xlink:href="fmed-11-1468654-g004.tif"/>
</fig>
<p>Results also indicate that students&#x2019; ability to employ positive coping strategies decreases with burnout. Despite psychological distress prompting the use of positive coping strategies, its mediating effect through burnout significantly reduces their utilization among medical students. Furthermore, positive coping strategies enhance empathy, with a standardized direct effect of 0.253 (<xref ref-type="table" rid="tab10">Tables 10</xref>, <xref ref-type="table" rid="tab11">11</xref>) this was predicted in H4.</p>
<table-wrap position="float" id="tab10">
<label>Table 10</label>
<caption>
<p>The estimates of standardized and unstandardized regression weights of variables for Model 3.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top" colspan="2">Endogenous variables</th>
<th align="center" valign="top">
<italic>&#x03B2;</italic>
</th>
<th align="center" valign="top">
<italic>B</italic>
</th>
<th align="center" valign="top">SE</th>
<th align="center" valign="top"><italic>p</italic>-values</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top" rowspan="2">Burnout (BurnoutScore)</td>
<td align="left" valign="top">Empathy (TEQScore)</td>
<td align="char" valign="top" char=".">&#x2212;0.083</td>
<td align="char" valign="top" char=".">&#x2212;0.064</td>
<td align="char" valign="top" char=".">0.059</td>
<td align="char" valign="top" char=".">0.281</td>
</tr>
<tr>
<td align="left" valign="top">Positve coping strategy (PCS)</td>
<td align="char" valign="top" char=".">&#x2212;0.207</td>
<td align="char" valign="top" char=".">&#x2212;0.007</td>
<td align="char" valign="top" char=".">0.003</td>
<td align="char" valign="top" char=".">0.024</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="2">Psychological distress (PDScore)</td>
<td align="left" valign="top">Empathy (TEQScore)</td>
<td align="char" valign="top" char=".">&#x2212;0.214</td>
<td align="char" valign="top" char=".">&#x2212;0.341</td>
<td align="char" valign="top" char=".">0.123</td>
<td align="char" valign="top" char=".">0.006</td>
</tr>
<tr>
<td align="left" valign="top">Positive coping strategy (PCS)</td>
<td align="char" valign="top" char=".">0.216</td>
<td align="char" valign="top" char=".">0.016</td>
<td align="char" valign="top" char=".">0.007</td>
<td align="char" valign="top" char=".">0.019</td>
</tr>
<tr>
<td align="left" valign="top">Positive coping strategy (PCS)</td>
<td align="left" valign="top">Empathy (TEQScore)</td>
<td align="char" valign="top" char=".">0.253</td>
<td align="char" valign="top" char=".">5.476</td>
<td align="char" valign="top" char=".">1.706</td>
<td align="char" valign="top" char=".">0.001</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>
<italic>&#x03B2;&#x2009;=&#x2009;standardized regression weights; B&#x2009;=&#x2009;unstandardized regression weights; SE&#x2009;=&#x2009;standard error. Estimates for PDScore &#x2192; BurnoutScore, PolyScore &#x2192; PDScore, PolyScore &#x2192; BurnoutScore remain the same as in <xref ref-type="table" rid="tab9">Table 9</xref>, hence not included here.</italic>
</p>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="tab11">
<label>Table 11</label>
<caption>
<p>The unstandardized and standardized estimates of direct, indirect, and total effects for variables relationships for Model 3.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Parameter</th>
<th align="center" valign="top" colspan="2">Variables relationship</th>
<th align="center" valign="top">Total (95% CI)</th>
<th align="center" valign="top">Direct (95% CI)</th>
<th align="center" valign="top">Indirect (95% CI)</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top" rowspan="6">Unstandardized</td>
<td align="left" valign="top">PolyScore</td>
<td align="left" valign="top">PDScore</td>
<td align="char" valign="top" char="(">&#x2212;0.025 (&#x2212;0.078, 0.034)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.025 (&#x2212;0.078, 0.034)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
<tr>
<td align="left" valign="top">PolyScore</td>
<td align="left" valign="top" rowspan="3">PCS</td>
<td align="char" valign="top" char="(">0.002 (0.000, 0.005)<sup>&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
<td align="center" valign="top">0.002 (0.000, 0.005)<sup>&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">PDScore</td>
<td align="char" valign="top" char="(">0.007 (&#x2212;0.004, 0.019)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">0.016 (0.005, 0.033)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.009 (&#x2212;0.020&#x2013;0.001)<sup>&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">BurnoutScore</td>
<td align="char" valign="top" char="(">&#x2212;0.007 (&#x2212;0.017, &#x2212;0.001)<sup>&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.007 (&#x2212;0.017, &#x2212;0.001)<sup>&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
<tr>
<td align="left" valign="top">BurnoutScore</td>
<td align="left" valign="top" rowspan="2">TEQScore</td>
<td align="char" valign="top" char="(">&#x2212;0.105 (&#x2212;0.248, 0.032)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.064 (&#x2212;0.187, 0.073)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.041 (&#x2212;0.101, &#x2212;0.007)<sup>&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">PCS</td>
<td align="char" valign="top" char="(">5.476 (1.992, 10.451)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">5.476 (1.992, 10.451)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="6">Standardized</td>
<td align="left" valign="top">PolyScore</td>
<td align="left" valign="top">PDScore</td>
<td align="char" valign="top" char="(">&#x2212;0.059 (&#x2212;0.186, 0.076)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.059 (&#x2212;0.186, 0.076)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
<tr>
<td align="left" valign="top">PolyScore</td>
<td align="left" valign="top" rowspan="3">PCS</td>
<td align="char" valign="top" char="(">0.058 (&#x2212;0.004, 0.129)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
<td align="center" valign="top">0.058 (&#x2212;0.004, 0.129)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">PDScore</td>
<td align="char" valign="top" char="(">0.098 (&#x2212;0.057, 0.236)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">0.216 (0.048, 0.385)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.118 (&#x2212;0.238, &#x2212;0.012)<sup>&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">BurnoutScore</td>
<td align="char" valign="top" char="(">&#x2212;0.207 (&#x2212;0.399, &#x2212;0.014)<sup>&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.207 (&#x2212;0.399, &#x2212;0.014)<sup>&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
<tr>
<td align="left" valign="top">BurnoutScore</td>
<td align="left" valign="top" rowspan="2">TEQScore</td>
<td align="char" valign="top" char="(">&#x2212;0.136 (&#x2212;0.309, 0.049)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.083 (&#x2212;0.253, 0.098)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.053 (&#x2212;0.129, &#x2212;0.008)<sup>&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">PCS</td>
<td align="char" valign="top" char="(">0.253 (0.102, 0.388)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">0.253 (0.102, 0.388)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>Bootstrap (1000) with 95% bias-corrected confidence interval: L&#x2009;=&#x2009;lower bound; U&#x2009;=&#x2009;upper bound; <sup>&#x002A;</sup><italic>p</italic>-value &#x003C;0.05; <sup>&#x002A;&#x002A;</sup><italic>p</italic>-value &#x003C;0.01; <sup>&#x002A;&#x002A;&#x002A;</sup><italic>p</italic>-value &#x003E;0.05. Estimates for PolyScore &#x2192; BurnoutScore, PDScore &#x2192; BurnoutScore, PolyScore &#x2192; TEQScore, PDScore &#x2192; TEQScore remain similar as in <xref ref-type="table" rid="tab10">Table 10</xref>, hence not included here.</p>
</table-wrap-foot>
</table-wrap>
<p>This study further revealed that Model 4 (<xref ref-type="fig" rid="fig5">Figure 5</xref>) helped us investigate the effects of NCS2 on medical students&#x2019; medical professionalism and mental well-being. This model has met the criteria for model fit: Chi-square/df&#x2009;=&#x2009;1.822, <italic>p</italic>&#x2009;=&#x2009;0.026, TLI&#x2009;=&#x2009;0.946, CFI&#x2009;=&#x2009;0.961, RMSEA&#x2009;=&#x2009;0.059, GFI&#x2009;=&#x2009;0.972, and NFI&#x2009;=&#x2009;0.956 (<xref ref-type="table" rid="tab7">Table 7</xref>). Moreover, as predicted by H4, the results regarding negative coping strategies (NCS), indicated that mental well-being issues (burnout and psychological distress) significantly contributed to NCS. While professional behavior does not directly influence NCS2, a significant indirect effect was observed as an inhibitor through burnout (<italic>&#x03B2;</italic>&#x2009;=&#x2009;&#x2212;0.113, <italic>p</italic>&#x2009;&#x003C;&#x2009;0.05) for negative coping strategies. This implied that professional behavior decreases the usage of NCS among medical students (<xref ref-type="table" rid="tab12">Tables 12</xref>, <xref ref-type="table" rid="tab13">13</xref>).</p>
<fig position="float" id="fig5">
<label>Figure 5</label>
<caption>
<p>The causal-effect relationship model among mental wellbeing issues, negative coping strategy, and medical professionalism (Model 4: MWBi-NCS2-MP).</p>
</caption>
<graphic xlink:href="fmed-11-1468654-g005.tif"/>
</fig>
<table-wrap position="float" id="tab12">
<label>Table 12</label>
<caption>
<p>The estimates of standardized and unstandardized regression weights of variables for Model 4.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top" colspan="2">Endogenous variables</th>
<th align="center" valign="top">
<italic>&#x03B2;</italic>
</th>
<th align="center" valign="top">
<italic>B</italic>
</th>
<th align="center" valign="top">SE</th>
<th align="center" valign="top"><italic>p</italic>-values</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top" rowspan="2">Burnout (BurnoutScore)</td>
<td align="left" valign="top">Negative coping strategy (NCS)</td>
<td align="char" valign="top" char=".">0.238</td>
<td align="char" valign="top" char=".">0.020</td>
<td align="char" valign="top" char=".">0.006</td>
<td align="char" valign="top" char=".">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="top">Empathy (TEQScore)</td>
<td align="char" valign="middle" char=".">&#x2212;0.157</td>
<td align="char" valign="middle" char=".">&#x2212;0.121</td>
<td align="char" valign="middle" char=".">0.063</td>
<td align="char" valign="middle" char=".">0.056</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="2">Psychological distress (PDScore)</td>
<td align="left" valign="top">Negative coping strategy (NCS)</td>
<td align="char" valign="top" char=".">548</td>
<td align="char" valign="top" char=".">0.094</td>
<td align="char" valign="top" char=".">0.012</td>
<td align="char" valign="top" char=".">&#x003C; 0.001</td>
</tr>
<tr>
<td align="left" valign="top">Empathy (TEQScore)</td>
<td align="char" valign="top" char=".">&#x2212;0.207</td>
<td align="char" valign="top" char=".">&#x2212;0.331</td>
<td align="char" valign="top" char=".">0.155</td>
<td align="char" valign="top" char=".">0.033</td>
</tr>
<tr>
<td align="left" valign="top">Negative coping strategy (NCS)</td>
<td align="left" valign="top">Empathy (TEQScore)</td>
<td align="char" valign="top" char=".">0.088</td>
<td align="char" valign="top" char=".">0.819</td>
<td align="char" valign="top" char=".">0.977</td>
<td align="char" valign="top" char=".">0.402</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>
<italic>&#x03B2;&#x2009;=&#x2009;standardized regression weights; B&#x2009;=&#x2009;unstandardized regression weights; SE&#x2009;=&#x2009;standard error. Estimates for PDScore &#x2192; BurnoutScore, PolyScore &#x2192; PDScore, PolyScore &#x2192; BurnoutScore remain the same as in <xref ref-type="table" rid="tab9">Table 9</xref>, hence not included here.</italic>
</p>
</table-wrap-foot>
</table-wrap>
<table-wrap position="float" id="tab13">
<label>Table 13</label>
<caption>
<p>The unstandardized and standardized estimates of direct, indirect, and total effects for variables relationships for Model 4.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top">Parameter</th>
<th align="center" valign="top" colspan="2">Variables relationship</th>
<th align="center" valign="top">Total (95% CI)</th>
<th align="center" valign="top">Direct (95% CI)</th>
<th align="center" valign="top">Indirect (95% CI)</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top" rowspan="6">Unstandardized</td>
<td align="left" valign="top">PolyScore</td>
<td align="left" valign="top">PDScore</td>
<td align="char" valign="top" char="(">&#x2212;0.025 (&#x2212;0.075, 0.031)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.025 (&#x2212;0.075, 0.031)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
<tr>
<td align="left" valign="top">PolyScore</td>
<td align="left" valign="top" rowspan="3">NCS</td>
<td align="char" valign="top" char="(">&#x2212;0.008 (&#x2212;0.016, &#x2212;0.002)<sup>&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
<td align="center" valign="top">&#x2212;0.008 (&#x2212;0.016, &#x2212;0.002)<sup>&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">PDScore</td>
<td align="char" valign="top" char="(">0.117 (0.094, 0.141)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">0.094 (0.069, 0.117)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">0.023 (0.009, 0.041)<sup>&#x002A;&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">Burnout Score</td>
<td align="char" valign="top" char="(">0.020 (0.007, 0.031)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">0.020 (0.007, 0.031)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
<tr>
<td align="left" valign="top">Burnout Score</td>
<td align="left" valign="top" rowspan="2">TEQScore</td>
<td align="char" valign="top" char="(">&#x2212;0.105 (&#x2212;0.252, 0.033)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.121 (&#x2212;0.263, 0.027)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">0.016 (&#x2212;0.040, 0.068)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">NCS</td>
<td align="char" valign="top" char="(">0.819 (&#x2212;2.309, 2.710)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">0.819 (&#x2212;2.309, 2.710)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="6">Standardized</td>
<td align="left" valign="top">PolyScore</td>
<td align="left" valign="top">PDScore</td>
<td align="char" valign="top" char="(">&#x2212;0.059 (&#x2212;0.179, 0.068)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.059 (&#x2212;0.179, 0.068)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
<tr>
<td align="left" valign="top">PolyScore</td>
<td align="left" valign="top" rowspan="3">NCS</td>
<td align="char" valign="top" char="(">&#x2212;0.113 (&#x2212;0.217, &#x2212;0.022)<sup>&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
<td align="center" valign="top">&#x2212;0.113 (&#x2212;0.217, &#x2212;0.022)<sup>&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">PDScore</td>
<td align="char" valign="top" char="(">0.683 (0.593, 0.772)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">0.548 (0.409, 0.661)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">0.135 (0.051.215)<sup>&#x002A;&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">Burnout Score</td>
<td align="char" valign="top" char="(">0.238 (0.085, 0.365)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">0.238 (0.085, 0.365)<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
<tr>
<td align="left" valign="top">Burnout Score</td>
<td align="left" valign="top" rowspan="2">TEQScore</td>
<td align="char" valign="top" char="(">&#x2212;0.136 (&#x2212;0.322, 0.043)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2212;0.157 (&#x2212;0.342, 0.033)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">0.021 (&#x2212;0.049, 0.086)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
</tr>
<tr>
<td align="left" valign="top">NCS</td>
<td align="char" valign="top" char="(">0.088 (&#x2212;0.231, 0.295)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">0.088 (&#x2212;0.231, 0.295)<sup>&#x002A;&#x002A;&#x002A;</sup></td>
<td align="center" valign="top">&#x2014;</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>Bootstrap (1000) with 95% bias-corrected confidence interval: L&#x2009;=&#x2009;lower bound; U&#x2009;=&#x2009;upper bound; <sup>&#x002A;</sup><italic>p</italic>-value &#x003C;0.05; <sup>&#x002A;&#x002A;</sup><italic>p</italic>-value &#x003C;0.01; <sup>&#x002A;&#x002A;&#x002A;</sup><italic>p</italic>-value &#x003E;0.05. Estimates for POLY Score &#x2192; Burnout Score, PDScore &#x2192; Burnout Score, PolyScore &#x2192; TEQScore, PDScore &#x2192; TEQScore remain similar as in <xref ref-type="table" rid="tab10">Table 10</xref>, hence not included here.</p>
</table-wrap-foot>
</table-wrap>
</sec>
</sec>
<sec sec-type="discussion" id="sec17">
<title>Discussion</title>
<p>Our study demonstrates that professional behavior significantly decreases burnout levels among medical students, indicating that a strong understanding and practice of professionalism may mitigate the risk of burnout. The support for Hypothesis 1 suggests that higher levels of medical professionalism are associated with improved mental well-being, aligning with previous studies that have emphasized professionalism as a buffer against burnout in healthcare settings. Prior research showing a correlation between burnout and unprofessional behaviors, as well as compromised patient care standards (<xref ref-type="bibr" rid="ref27 ref28 ref29">27&#x2013;29</xref>). Specifically, our findings resonate with Brazeau et al. (<xref ref-type="bibr" rid="ref30">30</xref>), who identified an inverse relationship between burnout levels and professionalism scores. Similarly, Dyrbye et al. (<xref ref-type="bibr" rid="ref31">31</xref>) linked burnout with self-reported unprofessional behaviors among physicians. These results underscore the global prevalence of burnout in medical schools (<xref ref-type="bibr" rid="ref32">32</xref>), and the inverse relationship we observed suggests that fostering a strong sense of professionalism in students may serve as a buffer against burnout, ultimately enhancing patient care standards. Our work highlights the critical role of professionalism in medical education, recommending that medical schools integrate comprehensive professionalism training to reduce burnout and improve healthcare outcomes.</p>
<p>Our study reveals that professional behavior demonstrates an indirect positive influence on the empathy levels of medical students by mitigating burnout. This finding aligns with global medical guidelines, such as those from the General Medical Council (GMC) in the UK and the Association of American Medical Colleges (AAMC), which emphasize the integral role of empathy in medical professionalism. Similar to our findings, previous studies have highlighted the relationship between reduced burnout and enhanced empathy among healthcare professionals. We postulate that professional behavior fosters a supportive learning environment, reducing stress and burnout, which in turn enhances empathy among medical students. Supporting this assumption, studies such as those by Shanafelt et al. (<xref ref-type="bibr" rid="ref27">27</xref>) and Dyrbye et al. (<xref ref-type="bibr" rid="ref33">33</xref>) have demonstrated that lower burnout levels correlate with higher empathy and better patient care. However, our study&#x2019;s limitations include potential biases from self-reported measures and its cross-sectional design, which limits causal inferences. Despite these limitations, our findings highlight the importance of integrating professionalism training in medical curricula to foster empathy, reduce burnout, and ultimately improve patient care. We recommend that medical schools adopt comprehensive professionalism programs, which could have significant implications on fostering empathy, reducing burnout, and also improving medical education, thus leading to better patient outcomes and enhanced healthcare delivery.</p>
<p>Our study indicates that positive professional behavior indirectly reduces negative coping strategies (NCSs) among medical students. This finding aligns with existing literature suggesting that coping strategies are influenced by personality traits and attributional styles (<xref ref-type="bibr" rid="ref34">34</xref>). Similar to our findings, previous research has shown that individuals with proactive, problem-oriented strategies tend to employ positive coping strategies (PCSs), while NCSs are negatively correlated with traits such as agreeableness and conscientiousness (<xref ref-type="bibr" rid="ref35">35</xref>). We postulate that nurturing medical professionalism helps students avoid negative coping methods by promoting positive behaviors and encouraging social support, thereby enhancing their mental well-being. Supporting this assumption, the literature indicates that professionalism can foster a helpful educational atmosphere that mitigates stress and promotes healthy coping mechanisms (<xref ref-type="bibr" rid="ref36">36</xref>). Our findings indicate the importance of incorporating professionalism training into medical curricula to promote healthy coping strategies. This has significant implications for medical education, suggesting that such training could advance learners&#x2019; mental health and overall well-being, ultimately leading to improved patient care.</p>
<p>This study highlights the significant impact of burnout on the coping strategies of medical students, influencing both positive coping strategies (PCSs) and negative coping strategies (NCSs). Similar findings have been reported globally, reflecting the increasing prevalence of emotional exhaustion among healthcare workers. For instance, studies in Saudi Arabia (<xref ref-type="bibr" rid="ref37">37</xref>) revealed high rates of burnout and depression among residents, while research in Romania (<xref ref-type="bibr" rid="ref38">38</xref>) found a significant burnout rate among medical students, particularly during the pandemic. Our findings align with global observations that burnout tends to influence coping strategies, with positive coping methods being more frequently utilized than negative ones in response to burnout, as observed in Singapore (<xref ref-type="bibr" rid="ref39">39</xref>), the USA (<xref ref-type="bibr" rid="ref40">40</xref>), Qatar (<xref ref-type="bibr" rid="ref41">41</xref>), and Saudi Arabia (<xref ref-type="bibr" rid="ref42">42</xref>, <xref ref-type="bibr" rid="ref43">43</xref>). We postulate that maintaining a positive attitude in the face of adversity is crucial for medical students to mitigate adverse effects on their mental health and enhance their overall performance. Supporting this assumption, evidence from various studies suggests that promoting positive coping strategies among students can contribute significantly to their emotional well-being and academic success (<xref ref-type="bibr" rid="ref44">44</xref>). The findings indicate the importance of fostering positive coping mechanisms within medical education to support students&#x2019; mental health and academic performance. We recommend that medical schools integrate programs that promote positive coping strategies, which could have significant implications for improving the overall well-being and effectiveness of future healthcare professionals.</p>
<p>Our study reveals that psychological distress increases the use of positive coping strategies (PCSs) among medical students, which does. This finding resonates with existing literature that underscores the pivotal role of social support in safeguarding mental health across diverse populations, including medical students. Similar studies have highlighted the importance of social support in mitigating psychological distress and promoting positive coping mechanisms. For instance, research indicates that social support networks are crucial for medical students to manage stress effectively, as demonstrated in studies across various countries like China (<xref ref-type="bibr" rid="ref45">45</xref>), Italy (<xref ref-type="bibr" rid="ref46">46</xref>), Canada (<xref ref-type="bibr" rid="ref47">47</xref>) and Australia (<xref ref-type="bibr" rid="ref48">48</xref>). Conversely, inadequate support from family and friends has been linked to a higher risk of depression among medical students in the United States (<xref ref-type="bibr" rid="ref49">49</xref>). We postulate that psychological distress may prompt medical students to actively seek out positive coping strategies, leveraging social support to enhance their mental resilience. This assumption is supported by literature emphasizing the beneficial effects of social support in reducing stress and improving coping mechanisms. Our findings highlight the critical role of fostering robust social support systems within medical education. We recommend that medical schools implement programs that strengthen social support networks and teach effective positive coping strategies, which could significantly enhance the mental well-being and academic success of medical students.</p>
<p>Our study highlights a substantial association between employing positive coping strategies (PCSs) and increasing the empathy levels of medical students, suggesting a positive correlation between coping and empathy. This finding is corroborated by previous research, such as that by Noda, Noda et al. (<xref ref-type="bibr" rid="ref50">50</xref>), which also identified a link between coping mechanisms and empathy. Empathy, closely tied to coping and stress, inherently influences coping mechanisms that involve supportive activities or interactions with others (<xref ref-type="bibr" rid="ref51">51</xref>). Furthermore, findings by Saha et al. (<xref ref-type="bibr" rid="ref52">52</xref>) confirm a positive correlation between empathic self-efficacy and adaptive coping techniques, while noting a negative correlation with maladaptive coping strategies. We postulate that more empathetic medical students are inclined towards using positive coping strategies when faced with stressful situations or conflicts, as empathy promotes supportive and adaptive responses (<xref ref-type="bibr" rid="ref51">51</xref>, <xref ref-type="bibr" rid="ref53">53</xref>). Supporting this assumption, the literature emphasizes the role of empathy in fostering positive coping behaviors. Our findings highlight the importance of fostering empathy among medical students to enhance their coping skills and overall well-being. We recommend that medical education programs integrate empathy training to encourage the use of positive coping strategies, which could significantly improve students&#x2019; mental health and professional performance.</p>
<p>Our study reveals a significant relationship between mental well-being issues and the adoption of negative coping strategies (NCSs) among medical students, particularly in response to burnout and psychological distress. This supports H4, and is consistent with earlier studies indicating that high levels of psychological distress, including depression, anxiety, and stress, positively correlate with the use of escape avoidance behaviors (<xref ref-type="bibr" rid="ref54">54</xref>). Additionally, studies by Grynberg and L&#x00F3;pez-P&#x00E9;rez (<xref ref-type="bibr" rid="ref55">55</xref>) have similarly highlighted distress&#x2019;s positive association with less healthy coping methods. We postulate that medical students experiencing mental well-being issues may resort to negative coping strategies as a means of escaping or avoiding stressful situations. This assumption is supported by literature emphasizing the detrimental impact of psychological distress on coping mechanisms, leading individuals to adopt maladaptive strategies in an attempt to cope with their emotions. Our findings highlight the importance of addressing mental well-being issues among medical students to mitigate the adoption of negative coping strategies. We recommend introducing extensive psychological and mental health support initiatives in medical education institutions to promote positive coping mechanisms and enhance overall student well-being. Such initiatives could have significant implications for improving the mental health and resilience of future health professionals, ultimately benefiting both students and the patients they serve.</p>
<p>Our study highlights a significant decrease in the empathy levels of medical students due to the direct and mediated effects of psychological distress. This finding aligns with previous research indicating that stress in medical practice can diminish empathy and overall performance quality (<xref ref-type="bibr" rid="ref56">56</xref>). Similarly, Bellini et al. (<xref ref-type="bibr" rid="ref57">57</xref>) found a negative correlation between distress, depression, and empathic concern. We postulate that anxiety, a component of psychological distress, may influence empathy due to heightened emotional sensitivity (<xref ref-type="bibr" rid="ref58">58</xref>). Understanding this complex relationship between psychological functioning and empathy is crucial for medical students, as empathy fosters compassion and supportive care. Despite variations in research findings, empathy remains integral to positive social interactions and effective patient care. Our findings highlight the importance of addressing psychological distress among medical students to preserve empathy levels and enhance overall patient care. We recommend implementing interventions that promote mental well-being and resilience within medical education to safeguard empathy and improve health outcomes. Such initiatives could have significant implications for both medical students and the patients they serve, ultimately contributing to a more compassionate and effective healthcare system.</p>
<p>This study collectively presents some limitations that necessitate attention. Firstly, the reliance on self-reported data introduces potential biases, as participants&#x2019; experiences and behaviors may be overreported or overlooked due to social desirability or recall bias. Secondly, the cross-sectional design of these studies limits the ability to draw causal inferences between variables, as we cannot definitively establish the directionality of the relationships observed. Additionally, the diverse cultural and educational contexts in which the work was conducted may negatively influence the generalizability of the findings. The work also did not account for all potentially confounding variables that could impact the relationships between psychological distress, coping strategies, empathy, and professional behavior. Authors feel there is need for further longitudinal and multi-site research to confirm and expand upon these results.</p>
<p>This study presents several notable strengths that enhance their contribution to understanding the mental health and professional behavior of medical students. Firstly, they address a critical and timely issue by exploring the multifaceted impact of psychological distress, burnout, and coping strategies on empathy and professionalism in medical education. The use of established and validated measures for assessing psychological distress, coping strategies, empathy, and professional behavior ensures the reliability and validity of the data collected. Additionally, the integration of both direct and mediated effects in the analyses provides a comprehensive understanding of the complex relationships among these variables. The findings are consistently aligned with existing literature, further validating the results and highlighting the global relevance of promoting mental well-being and positive coping mechanisms in medical education. These insights underscore the importance of fostering a supportive environment for medical students, which has significant implications for improving their mental health, empathy, and overall professional performance.</p>
<p>Based on the findings, several key recommendations and implications emerge for enhancing the mental well-being and professional development of medical students. It is crucial to integrate wide-ranging mental health backing plans within medical education to address psychological distress, thereby reducing the adoption of negative coping strategies and preserving empathy levels. The promotion of professional behavior should be emphasized as it indirectly mitigates burnout and enhances empathy and positive coping strategies. Medical curricula should incorporate training that fosters empathy, resilience, and positive coping mechanisms, which are vital for managing stress and improving patient care. Additionally, fostering robust social support networks among medical students can significantly enhance their coping skills and overall well-being. These interventions not only improve the mental health and professional behavior of medical students but also have far-reaching implications for patient care and the healthcare system. By implementing these recommendations, medical schools can better prepare students to face the challenges of their profession, leading to more compassionate and effective healthcare professionals.</p>
</sec>
<sec sec-type="conclusions" id="sec18">
<title>Conclusion</title>
<p>Mental wellness issues significantly impact medical students&#x2019; health, learning, and patient care abilities. Stress, anxiety, depression, and burnout harm empathy and professionalism. While students often use PCSs, NCSs are also not uncommon and exacerbate challenges. Recognizing and addressing these difficulties with tailored support and training is crucial. Ensuring students&#x2019; quality of life and teaching effective coping mechanisms are essential for their future roles in patient care and societal contributions.</p>
</sec>
</body>
<back>
<sec sec-type="data-availability" id="sec19">
<title>Data availability statement</title>
<p>The original contributions presented in the study are included in the article/<xref ref-type="supplementary-material" rid="SM1">Supplementary material</xref>, further inquiries can be directed to the corresponding author.</p>
</sec>
<sec sec-type="ethics-statement" id="sec20">
<title>Ethics statement</title>
<p>The studies involving humans were approved by JEPeM-University Sains Malaysia, Health Campus, Kelantan, Kota Bharu. The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study.</p>
</sec>
<sec sec-type="author-contributions" id="sec21">
<title>Author contributions</title>
<p>KS: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing &#x2013; original draft, Writing &#x2013; review &#x0026; editing. SM: Visualization, Writing &#x2013; review &#x0026; editing, Funding acquisition. MY: Visualization, Writing &#x2013; review &#x0026; editing, Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Validation.</p>
</sec>
<sec sec-type="funding-information" id="sec22">
<title>Funding</title>
<p>The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. King Saud University, Riyadh, Saudi Arabia [RSP 2024 R47].</p>
</sec>
<ack>
<p>The authors thank the researchers supporting project number RSP 2024 R47, King Saud University, Riyadh, Saudi Arabia.</p>
</ack>
<sec sec-type="COI-statement" id="sec23">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
<p>The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.</p>
</sec>
<sec sec-type="disclaimer" id="sec24">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<sec sec-type="supplementary-material" id="sec25">
<title>Supplementary material</title>
<p>The Supplementary material for this article can be found online at: <ext-link xlink:href="https://www.frontiersin.org/articles/10.3389/fmed.2024.1468654/full#supplementary-material" ext-link-type="uri">https://www.frontiersin.org/articles/10.3389/fmed.2024.1468654/full#supplementary-material</ext-link></p>
<supplementary-material xlink:href="Data_Sheet_1.docx" id="SM1" mimetype="application/vnd.openxmlformats-officedocument.wordprocessingml.document" xmlns:xlink="http://www.w3.org/1999/xlink"/>
</sec>
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