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<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Med.</journal-id>
<journal-title>Frontiers in Medicine</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Med.</abbrev-journal-title>
<issn pub-type="epub">2296-858X</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
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<article-meta>
<article-id pub-id-type="doi">10.3389/fmed.2024.1405375</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Medicine</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Study on the effect factors of discharge readiness of total hip arthroplasty patients</article-title>
</title-group>
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<name><surname>Liu</surname> <given-names>Pei</given-names></name>
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<name><surname>Chen</surname> <given-names>Weiqiang</given-names></name>
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<name><surname>Shan</surname> <given-names>Ying</given-names></name>
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<name><surname>Dai</surname> <given-names>Liang</given-names></name>
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<name><surname>Qin</surname> <given-names>Xianglan</given-names></name>
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<name><surname>Yang</surname> <given-names>Haoze</given-names></name>
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<name><surname>Ji</surname> <given-names>Xingchen</given-names></name>
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<name><surname>Tan</surname> <given-names>Zhen</given-names></name>
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<name><surname>Yu</surname> <given-names>Fei</given-names></name>
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<aff id="aff1"><sup>1</sup><institution>Department of Bone &#x0026; Joint Surgery, Peking University Shenzhen Hospital</institution>, <addr-line>Shenzhen</addr-line>, <country>China</country></aff>
<aff id="aff2"><sup>2</sup><institution>National &#x0026; Local Joint Engineering Research Center of Orthopedic Biomaterials</institution>, <addr-line>Shenzhen</addr-line>, <country>China</country></aff>
<aff id="aff3"><sup>3</sup><institution>Shenzhen Key Laboratory of Orthopedic Diseases and Biomaterials Research</institution>, <addr-line>Shenzhen</addr-line>, <country>China</country></aff>
<aff id="aff4"><sup>4</sup><institution>Clinical Research Academy, Peking University Shenzhen Hospital</institution>, <addr-line>Shenzhen</addr-line>, <country>China</country></aff>
<author-notes>
<fn fn-type="edited-by" id="fn0002">
<p>Edited by: Olga Ribeiro, Escola Superior de Enfermagem do Porto, Portugal</p>
</fn>
<fn fn-type="edited-by" id="fn0003">
<p>Reviewed by: Luis Miguel, Escola Superior de Enfermagem do Porto, Portugal</p>
<p>Luis Manuel Mota de Sousa, Universidade Atl&#x00E2;ntica, Portugal</p>
</fn>
<corresp id="c001">&#x002A;Correspondence: Fei Yu, <email>yufei89@pku.edu.cn</email></corresp>
<corresp id="c002">Zhen Tan, <email>tanzeric@bjmu.edu.cn</email></corresp>
<fn fn-type="equal" id="fn0001"><p><sup>&#x2020;</sup>These authors have contributed equally to this work</p></fn>
</author-notes>
<pub-date pub-type="epub">
<day>23</day>
<month>08</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="collection">
<year>2024</year>
</pub-date>
<volume>11</volume>
<elocation-id>1405375</elocation-id>
<history>
<date date-type="received">
<day>22</day>
<month>03</month>
<year>2024</year>
</date>
<date date-type="accepted">
<day>14</day>
<month>08</month>
<year>2024</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x00A9; 2024 Liu, Chen, Shan, Dai, Qin, Yang, Ji, Tan and Yu.</copyright-statement>
<copyright-year>2024</copyright-year>
<copyright-holder>Liu, Chen, Shan, Dai, Qin, Yang, Ji, Tan and Yu</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<abstract>
<sec>
<title>Introduction</title>
<p>In order to explore the correlation between discharge readiness and Harris score or self-care ability of patients undergoing total hip arthroplasty (THA) based on the enhanced recovery after surgery (ERAS) concept. We carried out this single center retrospective study.</p>
</sec>
<sec>
<title>Methods</title>
<p>We enrolled 331 patients who underwent THA. These patients were divided into the higher score group and the lower score group according to median discharge readiness score. After the baseline data of these patients were compared, the effect factors of discharge readiness of these patients was analyzed through univariate and multivariate logistic regression analyses and mixed effects models.</p>
</sec>
<sec>
<title>Results</title>
<p>The results demonstrated that there was a correlation between discharge readiness and changes in Harris score 30 days after discharge (compared with that before surgery) in these patients. Besides, the Harris score and self-care ability 30 days after discharge were higher than those at the time of discharge. In addition, patients in the higher score group exhibited a higher Harris score compared with those in the lower score group. From the evaluation at different time points after discharge, there was a significant difference in the Harris score between both groups.</p>
</sec>
<sec>
<title>Discussion</title>
<p>It can be inferred that the discharge readiness of patients undergoing THA was correlated with the Harris score but not with the self-care ability. These results are expected to provide guidance for the physical and mental recovery of patients undergoing total hip replacement under the ERAS concept. Furthermore, these findings may contribute to higher diagnosis, treatment, and nursing levels of orthopedic medical staff.</p>
</sec>
</abstract>
<kwd-group>
<kwd>total hip arthroplasty</kwd>
<kwd>discharge readiness</kwd>
<kwd>Harris score</kwd>
<kwd>self-care ability</kwd>
<kwd>ERAS concept</kwd>
</kwd-group>
<contract-num rid="cn1">A2022390</contract-num>
<contract-num rid="cn2">JCYJ20220531094401003</contract-num>
<contract-num rid="cn3">LCYJ2020019</contract-num>
<contract-num rid="cn4">82102568</contract-num>
<contract-num rid="cn5">SZXK023</contract-num>
<contract-num rid="cn6">SZSM202211038</contract-num>
<contract-num rid="cn7">2022A1515220111</contract-num>
<contract-num rid="cn7">2021A1515012586</contract-num>
<contract-num rid="cn8">KYQD2021099</contract-num>
<contract-sponsor id="cn1">Guangdong Medical Science and Technology Research Funding</contract-sponsor>
<contract-sponsor id="cn2">Shenzhen Science and Technology Program</contract-sponsor>
<contract-sponsor id="cn3">Research Foundation of Peking University Shenzhen Hospital</contract-sponsor>
<contract-sponsor id="cn4">National Natural Science Foundation of China<named-content content-type="fundref-id">10.13039/501100001809</named-content></contract-sponsor>
<contract-sponsor id="cn5">Shenzhen Key Medical Discipline Construction Fund</contract-sponsor>
<contract-sponsor id="cn6">Shenzhen &#x201C;San-Ming&#x201D; Project of Medicine</contract-sponsor>
<contract-sponsor id="cn7">Guangdong Basic and Applied Basic Research Foundation</contract-sponsor>
<contract-sponsor id="cn8">Peking University Shenzhen Hospital Scientific Research Fund</contract-sponsor>
<counts>
<fig-count count="0"/>
<table-count count="4"/>
<equation-count count="0"/>
<ref-count count="30"/>
<page-count count="8"/>
<word-count count="6065"/>
</counts>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-at-acceptance</meta-name>
<meta-value>Geriatric Medicine</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec sec-type="intro" id="sec1">
<label>1</label>
<title>Introduction</title>
<p>Total hip arthroplasty (THA) is a surgical treatment method for resolving advanced hip joint diseases with obvious pain, severe functional impairment, and ineffective conservative treatment caused by various reasons (<xref ref-type="bibr" rid="ref1">1</xref>). Patients can regain a well-functioning hip joint after THA, which has been considered one of the most successful surgical procedures in the 20th century (<xref ref-type="bibr" rid="ref2">2</xref>). The concept of enhanced recovery after surgery (ERAS) was first proposed by Dr. Kehlet, a Danish doctor, in 1997 and has been popularized worldwide. The ERAS concept was proposed based on multidisciplinary and multimodal methods, ultimately achieving accelerated recovery reduced incidence of complications, and improved prognosis (<xref ref-type="bibr" rid="ref3">3</xref>). The ERAS concept was initially applied to patients undergoing abdominal and colorectal surgery, but later extended to other specialties, such as orthopedic surgery, especially hip and knee joint arthroplasty (<xref ref-type="bibr" rid="ref4">4</xref>). Preoperative education/physical therapy, rational selection of anesthesia technology, optimization of multimodal analgesia, prevention of urinary retention and incidence of catheterization, active management of risks related to blood loss and deep vein thrombosis, and early mobilization of patients are all intervention methods under the ERAS concept. These methods may affect the physical and mental recovery of patients undergoing hip and knee replacement (<xref ref-type="bibr" rid="ref5">5</xref>). Therefore, the ERAS concept can be adopted in any perioperative period for patients undergoing hip replacement surgery.</p>
<p>The concept of discharge readiness was proposed earlier than the ERAS concept. It was initially proposed by Fenwick et al. (<xref ref-type="bibr" rid="ref6">6</xref>) in 1979 to identify whether patients were ready for discharge from both medical and patient perspectives and comprehensively evaluate the physiological, psychological, and social indicators of patients upon discharge through medical staff. Further, it can be employed to analyze the support that families and society can provide to patients and make judgments on their ability to return to society for subsequent rehabilitation. In recent years, discharge readiness has also received increasing attention with the extensive application of the ERAS concept. Additionally, patients with high discharge readiness scores are more significantly correlated with early rehabilitation and better prognosis under the ERAS concept, thus contributing to the comprehensive research on these two concepts (<xref ref-type="bibr" rid="ref7">7</xref>). Discharge readiness can be regarded as an assessment indicator of a patient&#x2019;s state before discharge, and it can be utilized to identify factors that may affect discharge readiness, and, to some extent, affect the promotion of ERAS concepts in related procedures (<xref ref-type="bibr" rid="ref8">8</xref>). The focus of most existing studies is placed on the readiness for discharge in the field of orthopedics. YaDeau et al. (<xref ref-type="bibr" rid="ref9">9</xref>) maintained that general anesthesia may be related to the discharge readiness of patients after foot and ankle surgery. Compared with patients receiving spinal anesthesia, those receiving general anesthesia can be discharged earlier. Sztain et al. (<xref ref-type="bibr" rid="ref10">10</xref>) found that for patients undergoing unicompartmental knee arthroplasty, compared with continuous femoral nerve block, continuous adductor canal block can improve the patient&#x2019;s conformity with predetermined standards and discharge criteria. The Harris score is a relatively objective scoring standard for evaluating hip joint functions. It is often used to evaluate changes in hip joint functions before and after surgery. The higher the Harris score, the better the hip joint function (<xref ref-type="bibr" rid="ref11">11</xref>). The self-care ability of patients is related to their quality of daily life. This indicator can be quantified by the Activities of Daily Living (ADL) score. The higher the ADL score, the stronger the self-care ability (<xref ref-type="bibr" rid="ref12">12</xref>). However, there are few reports on the discharge readiness in patients undergoing THA, especially the correlation between discharge readiness and Harris score or self-care ability.</p>
<p>In this study, we enrolled 331 patients who underwent THA in Department of Bone &#x0026; Joint Surgery at Peking University Shenzhen Hospital from January 2021 to February 2023. These patients were divided into the higher score group and the lower score group according to median discharge readiness score. In order to explore the correlation between discharge readiness and Harris score or self-care ability of these patients. These results are expected to provide guidance for the physical and mental recovery of patients undergoing THA under the ERAS concept. Furthermore, these findings may contribute to higher diagnosis, treatment, and nursing levels of orthopedic medical staff.</p>
</sec>
<sec sec-type="materials|methods" id="sec2">
<label>2</label>
<title>Materials and methods</title>
<sec id="sec3">
<label>2.1</label>
<title>Type of study</title>
<p>Single center retrospective study. A total of 331 patients who underwent THA in Department of Bone &#x0026; Joint Surgery at Peking University Shenzhen Hospital from January 2021 to February 2023 were included in this study.</p>
</sec>
<sec id="sec4">
<label>2.2</label>
<title>Grouping</title>
<p>After sorting based on their discharge readiness score, the median score was selected as the cutoff point. Based on that, these patients were divided into the lower score group (<italic>n</italic>&#x2009;=&#x2009;189) and the higher score group (<italic>n</italic>&#x2009;=&#x2009;142). This study was approved by the Ethics Committee of Peking University Shenzhen Hospital. The study complies with all regulations in clinical research.</p>
</sec>
<sec id="sec5">
<label>2.3</label>
<title>Clinical resources</title>
<p>The baseline data were captured by the HIS system, including the discharge readiness score, age, gender (male or female), BMI, height, weight, education level (illiterate/primary school, technical secondary school/secondary school, and college/university/master&#x2019;s degree), marital status (married, divorced/widowed), length of hospital stay, anesthesia method (general anesthesia, lumbar spinal cord/spinal canal anesthesia), adverse events within 30&#x2009;days after discharge, comorbidities, self-care ability (at admission, discharge, and 30&#x2009;days after discharge), Harris score (at admission, discharge, and 30&#x2009;days after discharge), discharge satisfaction, rehabilitation exercise compliance (discharge and 30&#x2009;days after discharge) of these patients were collected.</p>
</sec>
<sec id="sec6">
<label>2.4</label>
<title>Inclusion and exclusion criteria</title>
<p>The inclusion criteria included: &#x2460; patients aged 18&#x2009;&#x2264;&#x2009;age&#x2009;&#x2264;&#x2009;85&#x2009;years; &#x2461; patients receiving initial unilateral THA; &#x2462; patients with the ability to understand and cooperate with relevant instructions and complete the evaluation; &#x2463; patients without severe organ dysfunction (Organ dysfunction can lead to patient death or poor medical outcomes, and these individuals should prioritize saving lives rather than undergoing total hip arthroplasty to improve their quality of life); &#x2464; patients with the ASA grade&#x2009;&#x2264;&#x2009;3; &#x2465; patients with complete follow-up data within 30&#x2009;days after discharge; and &#x2466;informed consent was obtained from the patient(s) for the PUBLICATION of clinical data and other data. The exclusion criteria included: &#x2460; patients with cognitive disorders, such as Alzheimer&#x2019;s disease, which may hinder their participation and evaluation; and &#x2461; patients with other illnesses that may require treatment during hospitalization.</p>
</sec>
<sec id="sec7">
<label>2.5</label>
<title>Collection of main research data</title>
<p>The discharge readiness score was obtained using the Readiness for Hospital Discharge Scale (RHDS). The Activities of Daily Living (ADL) score can be rated as 0&#x2013;100 points, with higher scores indicating stronger ADL abilities (It is equal to the changing of Barthel index). The Harris score was obtained using the Harris Hip Rehabilitation Scale. The rehabilitation compliance of these patients was evaluated based on the previous research methods of our research group (<xref ref-type="bibr" rid="ref13">13</xref>).</p>
</sec>
<sec id="sec8">
<label>2.6</label>
<title>Statistical methods and data analysis</title>
<p>SPSS 18.0 was used for data analysis. The metrological data that were normally distributed were represented by mean&#x2009;&#x00B1;&#x2009;standard deviation, and the differences between the two groups were compared using the two-sample <italic>t</italic>-test. In contrast, the metrological data that were not normally distributed were represented by the median (interquartile interval), and the differences between the two groups were compared using the Mann&#x2013;Whitney U test. The counting data were expressed in frequency (percentage), and intergroup differences were analyzed through the &#x03C7;2 test. The correlation between discharge readiness and Harris score or self-care ability was analyzed by univariate logistic regression and multivariate logistic regression analyses, respectively. In the multivariate logistic analysis, the adjusted covariates included age, gender, height, weight, marital status, length of hospital stay, anesthesia methods, comorbidities, and postoperative rehabilitation exercise compliance. The correlation between discharge readiness and Harris score or self-care ability over time was analyzed based on a mixed effects model. The adjusted covariates included age, gender, height, weight, marital status, length of hospital stay, anesthesia method, preoperative Harris score/self-care ability upon admission; postoperative rehabilitation exercise compliance; types of comorbidities. <italic>p</italic>&#x2009;&#x003C;&#x2009;0.05 indicated that there was a statistical difference.</p>
</sec>
</sec>
<sec sec-type="results" id="sec9">
<label>3</label>
<title>Results</title>
<sec id="sec10">
<label>3.1</label>
<title>Baseline data evaluation</title>
<p>Compared with patients in the lower score group, patients in the higher score group exhibited higher levels of education, length of hospital stay, Harris score 30&#x2009;days after discharge, satisfaction with discharge, and compliance with rehabilitation exercise, with statistically significant differences (<italic>p</italic>&#x2009;&#x003C;&#x2009;0.05) (<xref ref-type="table" rid="tab1">Table 1</xref>).</p>
<table-wrap position="float" id="tab1">
<label>Table 1</label>
<caption>
<p>Comparison of baseline data between these two groups.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th align="left" valign="top" colspan="2">Item</th>
<th align="center" valign="top">Lower score group (189)</th>
<th align="center" valign="top">Higher score group (142)</th>
<th align="center" valign="top"><italic>p</italic>-value</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="top" colspan="2">Discharge readiness</td>
<td align="center" valign="top">86.27&#x2009;&#x00B1;&#x2009;6.13</td>
<td align="center" valign="top">95.39&#x2009;&#x00B1;&#x2009;3.55</td>
<td align="center" valign="top">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="top" colspan="2">Age (year)</td>
<td align="center" valign="top">66 (60, 71)</td>
<td align="center" valign="top">66 (58, 75.75)</td>
<td align="center" valign="top">0.633</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="2">Gender (%)</td>
<td align="left" valign="top">Male</td>
<td align="center" valign="top">76 (40.2)</td>
<td align="center" valign="top">53 (37.3)</td>
<td align="center" valign="top" rowspan="2">0.675</td>
</tr>
<tr>
<td align="left" valign="top">Female</td>
<td align="center" valign="top">113 (59.8)</td>
<td align="center" valign="top">89 (62.7)</td>
</tr>
<tr>
<td align="left" valign="top" colspan="2">BMI</td>
<td align="center" valign="top">23.72&#x2009;&#x00B1;&#x2009;3.16</td>
<td align="center" valign="top">23.75&#x2009;&#x00B1;&#x2009;3.35</td>
<td align="center" valign="top">0.937</td>
</tr>
<tr>
<td align="left" valign="top" colspan="2">Height (cm)</td>
<td align="center" valign="top">159.93&#x2009;&#x00B1;&#x2009;7.59</td>
<td align="center" valign="top">160.68&#x2009;&#x00B1;&#x2009;8.48</td>
<td align="center" valign="top">0.397</td>
</tr>
<tr>
<td align="left" valign="top" colspan="2">Weight (kg)</td>
<td align="center" valign="top">60.75&#x2009;&#x00B1;&#x2009;9.87</td>
<td align="center" valign="top">61.18&#x2009;&#x00B1;&#x2009;10.24</td>
<td align="center" valign="top">0.701</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="3">Education level (%)</td>
<td align="left" valign="top">Illiterate/Primary school</td>
<td align="center" valign="top">83 (43.9)</td>
<td align="center" valign="top">38 (26.8)</td>
<td align="center" valign="top" rowspan="3">0.004</td>
</tr>
<tr>
<td align="left" valign="top">Technical secondary school/Secondary school</td>
<td align="center" valign="top">80 (42.3)</td>
<td align="center" valign="top">84 (59.1)</td>
</tr>
<tr>
<td align="left" valign="top">College/University/Master&#x2019;s degree</td>
<td align="center" valign="top">26 (13.8)</td>
<td align="center" valign="top">20 (14.1)</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="2">Marital status (%)</td>
<td align="left" valign="top">Married</td>
<td align="center" valign="top">160 (84.7)</td>
<td align="center" valign="top">116 (81.7)</td>
<td align="center" valign="top" rowspan="2">0.57</td>
</tr>
<tr>
<td align="left" valign="top">Divorced/Widowed</td>
<td align="center" valign="top">29 (15.3)</td>
<td align="center" valign="top">26 (18.3)</td>
</tr>
<tr>
<td align="left" valign="top" colspan="2">Length of hospital stay (day)</td>
<td align="center" valign="top">10 (8, 13)</td>
<td align="center" valign="top">11 (9, 15)</td>
<td align="center" valign="top">0.025</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="2">Anesthesia method (%)</td>
<td align="left" valign="top">General anesthesia</td>
<td align="center" valign="top">109 (57.7)</td>
<td align="center" valign="top">70 (49.3)</td>
<td align="center" valign="top" rowspan="2">0.161</td>
</tr>
<tr>
<td align="left" valign="top">Lumbar spinal cord/Spinal canal anesthesia</td>
<td align="center" valign="top">80 (42.3)</td>
<td align="center" valign="top">72 (50.7)</td>
</tr>
<tr>
<td align="left" valign="top">Adverse events within 30&#x2009;days after discharge (%)</td>
<td align="left" valign="top">Yes</td>
<td align="center" valign="top">2 (1)</td>
<td align="center" valign="top">3 (2.1)</td>
<td align="center" valign="top">0.426</td>
</tr>
<tr>
<td align="left" valign="top">Comorbidities (%)</td>
<td align="left" valign="top">Yes</td>
<td align="center" valign="top">119 (63)</td>
<td align="center" valign="top">106 (74.6)</td>
<td align="center" valign="top">0.033</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="3">Self-care ability</td>
<td align="left" valign="top">Admission</td>
<td align="center" valign="top">95 (70, 95)</td>
<td align="center" valign="top">92.5 (55, 95)</td>
<td align="center" valign="top">0.312</td>
</tr>
<tr>
<td align="left" valign="top">Discharge</td>
<td align="center" valign="top">85 (80, 90)</td>
<td align="center" valign="top">85 (80, 90)</td>
<td align="center" valign="top">0.824</td>
</tr>
<tr>
<td align="left" valign="top">30&#x2009;days after discharge</td>
<td align="center" valign="top">95 (90, 100)</td>
<td align="center" valign="top">95 (90, 100)</td>
<td align="center" valign="top">0.525</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="3">Harris score</td>
<td align="left" valign="top">Admission</td>
<td align="center" valign="top">45 (32, 52)</td>
<td align="center" valign="top">46 (26, 50)</td>
<td align="center" valign="top">0.517</td>
</tr>
<tr>
<td align="left" valign="top">Discharge</td>
<td align="center" valign="top">64 (61, 70)</td>
<td align="center" valign="top">65 (60, 71)</td>
<td align="center" valign="top">0.278</td>
</tr>
<tr>
<td align="left" valign="top">30&#x2009;days after discharge</td>
<td align="center" valign="top">77.32&#x2009;&#x00B1;&#x2009;5.73</td>
<td align="center" valign="top">80.8&#x2009;&#x00B1;&#x2009;7.21</td>
<td align="center" valign="top">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="top" colspan="2">Discharge satisfaction</td>
<td align="center" valign="top">91.1 (89.3, 94.6)</td>
<td align="center" valign="top">92.9 (89.4, 96.35)</td>
<td align="center" valign="top">0.001</td>
</tr>
<tr>
<td align="left" valign="top" rowspan="2">Rehabilitation exercise compliance</td>
<td align="left" valign="top">Postoperative</td>
<td align="center" valign="top">53 (48, 56)</td>
<td align="center" valign="top">56 (52, 58)</td>
<td align="center" valign="top">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="top">30&#x2009;days after discharge</td>
<td align="center" valign="top">54 (49, 59)</td>
<td align="center" valign="top">58 (55, 60)</td>
<td align="center" valign="top">&#x003C;0.001</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
<sec id="sec11">
<label>3.2</label>
<title>Logistic regression analysis of the correlation between discharge readiness and Harris score or self-care ability</title>
<p>There was no significant difference in preoperative Harris score between the higher score group and the lower score group (<italic>p</italic>&#x2009;=&#x2009;0.083). The multivariate regression results showed a correlation between the discharge readiness and changes in the Harris score 30&#x2009;days after discharge (compared with that before surgery) of patients undergoing THA (<italic>p</italic>&#x2009;&#x003C;&#x2009;0.001). However, no sufficient evidence was observed to prove that discharge readiness was related to changes in Harris score at discharge, self-care ability at admission, self-care ability at discharge, and self-care ability 30&#x2009;days after discharge (compared with that before surgery) (<italic>p</italic>&#x2009;&#x003E;&#x2009;0.05) (<xref ref-type="table" rid="tab2">Table 2</xref>).</p>
<table-wrap position="float" id="tab2">
<label>Table 2</label>
<caption>
<p>Correlation between discharge readiness and Harris score or self-care ability.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th/>
<th align="center" valign="top">Coefficient</th>
<th align="center" valign="top">Standard deviation</th>
<th align="center" valign="top"><italic>T</italic> value</th>
<th align="center" valign="top"><italic>p</italic>-value</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle">Preoperative Harris score</td>
<td align="center" valign="middle">0.012</td>
<td align="center" valign="middle">0.090</td>
<td align="center" valign="middle">0.132</td>
<td align="center" valign="middle">0.895</td>
</tr>
<tr>
<td align="left" valign="middle">Harris score changes at discharge<sup>&#x002A;</sup></td>
<td align="center" valign="middle">0.120</td>
<td align="center" valign="middle">0.095</td>
<td align="center" valign="middle">1.258</td>
<td align="center" valign="middle">0.209</td>
</tr>
<tr>
<td align="left" valign="middle">Harris score changes 30&#x2009;days after discharge<sup>&#x002A;</sup></td>
<td align="center" valign="middle">0.336</td>
<td align="center" valign="middle">0.093</td>
<td align="center" valign="middle">3.624</td>
<td align="center" valign="middle">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="middle">Self-care ability at admission</td>
<td align="center" valign="middle">&#x2212;0.093</td>
<td align="center" valign="middle">0.151</td>
<td align="center" valign="middle">&#x2212;0.616</td>
<td align="center" valign="middle">0.538</td>
</tr>
<tr>
<td align="left" valign="middle">Self-care ability changes at admission<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="middle">0.110</td>
<td align="center" valign="middle">0.143</td>
<td align="center" valign="middle">0.772</td>
<td align="center" valign="middle">0.441</td>
</tr>
<tr>
<td align="left" valign="middle">Self-care ability changes 30&#x2009;days after discharge<sup>&#x002A;&#x002A;</sup></td>
<td align="center" valign="middle">0.089</td>
<td align="center" valign="middle">0.141</td>
<td align="center" valign="middle">0.633</td>
<td align="center" valign="middle">0.527</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<p>&#x002A;It refers to the change in Harris score compared with that before surgery. &#x002A;&#x002A;It refers to the change in self-care ability compared with that before surgery.</p>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="sec12">
<label>3.3</label>
<title>Mixed effects model analysis of the correlation between discharge readiness and Harris score or self-care ability over time</title>
<p>Patients undergoing THA had a 12.95-point higher Harris score 30&#x2009;days after discharge than that at discharge (<italic>p</italic>&#x2009;&#x003C;&#x2009;0.001). The Harris score of the higher score group was on average 4.002 points higher than that of the lower score group (<italic>p</italic>&#x2009;=&#x2009;0.004). From the evaluation at different time points after discharge, there was a significant difference in the Harris score between both groups (interaction term <italic>p</italic>&#x2009;&#x003C;&#x2009;0.001) (<xref ref-type="table" rid="tab3">Table 3</xref>).</p>
<table-wrap position="float" id="tab3">
<label>Table 3</label>
<caption>
<p>Correlation between discharge readiness and Harris score over time.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th/>
<th align="center" valign="top">Coefficient</th>
<th align="center" valign="top">Standard deviation</th>
<th align="center" valign="top"><italic>T</italic> value</th>
<th align="center" valign="top"><italic>p</italic>-value</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle">Time</td>
<td align="center" valign="middle">12.952</td>
<td align="center" valign="middle">0.531</td>
<td align="center" valign="middle">24.390</td>
<td align="center" valign="middle">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="middle">Discharge readiness grouping</td>
<td align="center" valign="middle">4.002</td>
<td align="center" valign="middle">1.394</td>
<td align="center" valign="middle">2.871</td>
<td align="center" valign="middle">0.004</td>
</tr>
<tr>
<td align="left" valign="middle">Age</td>
<td align="center" valign="middle">&#x2212;0.015</td>
<td align="center" valign="middle">0.041</td>
<td align="center" valign="middle">&#x2212;0.369</td>
<td align="center" valign="middle">0.712</td>
</tr>
<tr>
<td align="left" valign="middle">Gender</td>
<td align="center" valign="middle">&#x2212;0.111</td>
<td align="center" valign="middle">0.889</td>
<td align="center" valign="middle">&#x2212;0.125</td>
<td align="center" valign="middle">0.901</td>
</tr>
<tr>
<td align="left" valign="middle">Height</td>
<td align="center" valign="middle">0.051</td>
<td align="center" valign="middle">0.063</td>
<td align="center" valign="middle">0.807</td>
<td align="center" valign="middle">0.420</td>
</tr>
<tr>
<td align="left" valign="middle">Weight</td>
<td align="center" valign="middle">&#x2212;0.040</td>
<td align="center" valign="middle">0.041</td>
<td align="center" valign="middle">&#x2212;0.957</td>
<td align="center" valign="middle">0.339</td>
</tr>
<tr>
<td align="left" valign="middle">Anesthesia method</td>
<td align="center" valign="middle">&#x2212;0.445</td>
<td align="center" valign="middle">0.666</td>
<td align="center" valign="middle">&#x2212;0.669</td>
<td align="center" valign="middle">0.504</td>
</tr>
<tr>
<td align="left" valign="middle">Marital status</td>
<td align="center" valign="middle">&#x2212;0.080</td>
<td align="center" valign="middle">0.908</td>
<td align="center" valign="middle">&#x2212;0.088</td>
<td align="center" valign="middle">0.930</td>
</tr>
<tr>
<td align="left" valign="middle">Length of hospital stay</td>
<td align="center" valign="middle">&#x2212;0.118</td>
<td align="center" valign="middle">0.084</td>
<td align="center" valign="middle">&#x2212;1.399</td>
<td align="center" valign="middle">0.163</td>
</tr>
<tr>
<td align="left" valign="middle">Comorbidities</td>
<td align="center" valign="middle">0.263</td>
<td align="center" valign="middle">0.747</td>
<td align="center" valign="middle">0.352</td>
<td align="center" valign="middle">0.725</td>
</tr>
<tr>
<td align="left" valign="middle">Postoperative rehabilitation exercise compliance</td>
<td align="center" valign="middle">0.059</td>
<td align="center" valign="middle">0.060</td>
<td align="center" valign="middle">0.973</td>
<td align="center" valign="middle">0.331</td>
</tr>
<tr>
<td align="left" valign="middle">Preoperative Harris score</td>
<td align="center" valign="middle">0.186</td>
<td align="center" valign="middle">0.032</td>
<td align="center" valign="middle">5.905</td>
<td align="center" valign="middle">&#x003C;0.001</td>
</tr>
<tr>
<td align="left" valign="middle">Time: Discharge readiness</td>
<td align="center" valign="middle">3.843</td>
<td align="center" valign="middle">0.811</td>
<td align="center" valign="middle">4.740</td>
<td align="center" valign="middle">&#x003C;0.001</td>
</tr>
</tbody>
</table>
</table-wrap>
<p>Patients undergoing THA had a self-care ability score 30&#x2009;days after discharge of 11.53 points higher compared with that at discharge (<italic>p</italic>&#x2009;&#x2009;&#x003C;&#x2009;0.001). However, there was insufficient evidence to prove that there was a significant difference in the average self-care ability score between both groups (<italic>p</italic>&#x2009;=&#x2009;0.888). From the evaluation at different time points after discharge, a significant difference in self-care ability score between both groups cannot be observed (interaction term <italic>p</italic>&#x2009;=&#x2009;0.792) (<xref ref-type="table" rid="tab4">Table 4</xref>).</p>
<table-wrap position="float" id="tab4">
<label>Table 4</label>
<caption>
<p>Correlation between discharge readiness and self-care ability over time.</p>
</caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th/>
<th align="center" valign="top">Coefficient</th>
<th align="center" valign="top">Standard deviation</th>
<th align="center" valign="top"><italic>T</italic> value</th>
<th align="center" valign="top"><italic>p</italic>-value</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left" valign="middle">Time</td>
<td align="center" valign="middle">11.534</td>
<td align="center" valign="middle">0.579</td>
<td align="center" valign="middle">19.910</td>
<td align="center" valign="middle">0.001</td>
</tr>
<tr>
<td align="left" valign="middle">Discharge readiness grouping</td>
<td align="center" valign="middle">0.203</td>
<td align="center" valign="middle">1.441</td>
<td align="center" valign="middle">0.141</td>
<td align="center" valign="middle">0.888</td>
</tr>
<tr>
<td align="left" valign="middle">Age</td>
<td align="center" valign="middle">&#x2212;0.076</td>
<td align="center" valign="middle">0.034</td>
<td align="center" valign="middle">&#x2212;2.206</td>
<td align="center" valign="middle">0.028</td>
</tr>
<tr>
<td align="left" valign="middle">Gender</td>
<td align="center" valign="middle">&#x2212;0.407</td>
<td align="center" valign="middle">0.741</td>
<td align="center" valign="middle">&#x2212;0.549</td>
<td align="center" valign="middle">0.583</td>
</tr>
<tr>
<td align="left" valign="middle">Height</td>
<td align="center" valign="middle">&#x2212;0.097</td>
<td align="center" valign="middle">0.053</td>
<td align="center" valign="middle">&#x2212;1.828</td>
<td align="center" valign="middle">0.068</td>
</tr>
<tr>
<td align="left" valign="middle">Weight</td>
<td align="center" valign="middle">0.043</td>
<td align="center" valign="middle">0.034</td>
<td align="center" valign="middle">1.264</td>
<td align="center" valign="middle">0.207</td>
</tr>
<tr>
<td align="left" valign="middle">Anesthesia method</td>
<td align="center" valign="middle">&#x2212;0.365</td>
<td align="center" valign="middle">0.548</td>
<td align="center" valign="middle">&#x2212;0.667</td>
<td align="center" valign="middle">0.505</td>
</tr>
<tr>
<td align="left" valign="middle">Marital status</td>
<td align="center" valign="middle">2.038</td>
<td align="center" valign="middle">0.738</td>
<td align="center" valign="middle">2.761</td>
<td align="center" valign="middle">0.006</td>
</tr>
<tr>
<td align="left" valign="middle">Length of hospital stay</td>
<td align="center" valign="middle">&#x2212;0.063</td>
<td align="center" valign="middle">0.071</td>
<td align="center" valign="middle">&#x2212;0.894</td>
<td align="center" valign="middle">0.372</td>
</tr>
<tr>
<td align="left" valign="middle">Comorbidities</td>
<td align="center" valign="middle">&#x2212;0.088</td>
<td align="center" valign="middle">0.608</td>
<td align="center" valign="middle">&#x2212;0.145</td>
<td align="center" valign="middle">0.885</td>
</tr>
<tr>
<td align="left" valign="middle">Postoperative rehabilitation exercise compliance</td>
<td align="center" valign="middle">&#x2212;0.071</td>
<td align="center" valign="middle">0.050</td>
<td align="center" valign="middle">&#x2212;1.426</td>
<td align="center" valign="middle">0.155</td>
</tr>
<tr>
<td align="left" valign="middle">Self-care ability changes at admission</td>
<td align="center" valign="middle">0.131</td>
<td align="center" valign="middle">0.015</td>
<td align="center" valign="middle">8.439</td>
<td align="center" valign="middle">0.001</td>
</tr>
<tr>
<td align="left" valign="middle">Time: discharge readiness</td>
<td align="center" valign="middle">0.233</td>
<td align="center" valign="middle">0.884</td>
<td align="center" valign="middle">0.264</td>
<td align="center" valign="middle">0.792</td>
</tr>
</tbody>
</table>
</table-wrap>
</sec>
</sec>
<sec sec-type="discussion" id="sec13">
<label>4</label>
<title>Discussion</title>
<p>Total hip arthroplasty (THA) is suitable for patients with advanced hip joint diseases, severe functional impairment, and ineffective conservative treatment caused by various reasons (<xref ref-type="bibr" rid="ref14">14</xref>). With the advancement of medicine, the ERAS concept proposed by Kehlet has been widely applied in orthopedic fields, such as THA, thus bringing good news to patients and challenges to medical staff (<xref ref-type="bibr" rid="ref15">15</xref>). The discharge readiness of patients is closely related to the ERAS concept (<xref ref-type="bibr" rid="ref16">16</xref>), and medical staff can evaluate the physical, mental, and social conditions of patients during hospitalization, thereby guiding their further recovery after discharge. However, in the field of orthopedics, especially THA, there are few reports on the relationship between the discharge readiness and functional indicators of patients. In view of this, a single-center retrospective cohort study was conducted based on the ERAS concept to explore the correlation between discharge readiness and Harris score or self-care ability in patients undergoing THA. These scientific efforts may provide new strategies and plans for orthopedic medical staff to achieve higher diagnosis, treatment, and nursing levels. This is also conducive to the postoperative physical and mental recovery of patients.</p>
<p>In this study, the information on 331 patients undergoing THA was retrospectively collected, and these patients were divided into the lower score group and the higher score group based on their discharge readiness scores. The baseline data (age, gender, height, weight, and BMI) were consistent between the two groups with no significant differences. However, patients with higher discharge readiness scores exhibited higher levels of education, length of stay, Harris score 30&#x2009;days after discharge, satisfaction with discharge, and compliance with rehabilitation exercises. Kaya et al. (<xref ref-type="bibr" rid="ref17">17</xref>) found that age, gender, marital status, educational status, the presence or absence of caregivers at home after discharge, and length of hospital stay were predictive factors for discharge readiness. Insufficient preparation for discharge increased the risk of 30-day unplanned readmission and 30-day death. Yang et al. (<xref ref-type="bibr" rid="ref18">18</xref>) verified that the education at discharge and the discharge status of rehabilitation institutions were related to the readiness of colorectal cancer patients for discharge readiness. Medical staff should improve the quality of discharge guidance and pay more attention to patients who are transferred to rehabilitation institutions for further treatment after discharge. Similar to this study, Heine et al. (<xref ref-type="bibr" rid="ref19">19</xref>) explored the influencing factors of discharge readiness in patients undergoing THA. They confirmed that &#x201C;confidence,&#x201D; &#x201C;family and friends,&#x201D; and &#x201C;feeling safe&#x201D; were important factors that affected the discharge readiness of these patients. These patients hoped to be safe in the hospital and at home, and their confidence and sense of security from friends and family at home were very important. Patients with a sense of security presented better preparation for discharge. Scatizzi et al. (<xref ref-type="bibr" rid="ref20">20</xref>) found that age and cancer risks can affect the discharge preparation time of patients with colorectal cancer after surgery. Borgwardt et al. (<xref ref-type="bibr" rid="ref21">21</xref>) made an exploration based on patients with unicompartmental knee arthroplasty in the field of orthopedics and found that adopting accelerated care procedures could shorten the hospitalization time of such patients, which also demonstrated the importance of discharge readiness under the ERAS concept. Based on existing studies, there were consistent baseline data for the basic situation of patients with high and low discharge readiness scores after THA. However, education level, length of hospital stay, Harris score 30&#x2009;days after discharge, discharge satisfaction, and rehabilitation exercise compliance might be influencing factors on the discharge readiness of patients undergoing THA. Overall, the higher the education level of patients, the easier it was for patients to understand the medical advice of medical staff and follow the doctor&#x2019;s instructions for preoperative preparation and postoperative exercise. This contributed to the recovery of hip joint functions. Therefore, patients with a higher education level regained better hip joint functions, and they were more likely to meet discharge standards. Besides, these patients presented higher satisfaction with diagnosis and treatment and more trust in medical staff, and they were more likely to cooperate with subsequent rehabilitation plans. Their confidence and trust in friends and family were also stronger. This also gave us a reminder that medical staff needed to be more patient with patients with low discharge readiness scores, communicate with them in plain language, help them correctly understand the disease, increase their compliance with medical advice, enhance their confidence in facing the disease, and improve their discharge readiness, which contributed to their recovery after discharge. For patients with high discharge readiness scores, medical staff could spend more time on developing more precise perioperative diagnosis and treatment plans. When communicating with these patients, they needed to improve their awareness and implement the collaborative diagnosis and treatment to transform the patients with low discharge readiness scores into those with high discharge readiness ones, which conduced to better recovery of these patients. Therefore, it is necessary to improve the discharge preparation of all patients under the guidance of the ERAS concept, which would be of great significance for the rehabilitation of patients undergoing THA.</p>
<p>In this study, it was also found that there was a correlation between discharge readiness and changes in the Harris score 30&#x2009;days after discharge (compared with that before THA). The Harris score 30&#x2009;days after discharge was higher than that at discharge. Patients with higher discharge readiness scores also had higher Harris scores compared with those with low discharge readiness scores. From the evaluation at different time points after discharge, there was a significant difference in the Harris score between the higher and lower score groups. However, there was no sufficient evidence to prove that discharge readiness was related to changes in the Harris score at discharge (compared with that before surgery). S&#x00F6;derman et al. (<xref ref-type="bibr" rid="ref22">22</xref>) evaluated the effectiveness of the Harris score in THA. They compared the results with that of the Western Ontario and McMaster University Osteoarthritis Index and the Medical Outcomes Study 36-Item Short Form Health Survey. Eventually, they concluded that the Harris score could be applied to patients undergoing THA. Kladny et al. (<xref ref-type="bibr" rid="ref23">23</xref>) demonstrated that the Harris score increased significantly in patients after hip arthroplasty, and it was not related to the gender, age, comorbidities, and weight of patients. Hersnase et al. (<xref ref-type="bibr" rid="ref24">24</xref>) analyzed the Harris score and SF-36 score in the 5-year follow-up after THA with two different prostheses. They found that both scores were effective in relevant assessments. Weel et al. (<xref ref-type="bibr" rid="ref25">25</xref>) evaluated the effectiveness of the Harris score in THA. They maintained that compared with the Oxford score, the Harris score presented higher evaluation effectiveness, while the Oxford score exhibited better internal consistency and reliability. From this, it could be observed that the Harris score was very important in the evaluation of THA. In this study, the Harris score generally increased after THA, and hence the Harris score at discharge and 30&#x2009;days after discharge would be higher than that at admission. The higher the Harris score, the better the recovery of hip joint functions. In addition, these patients also exhibited higher satisfaction with diagnosis and treatment, and they presented more confidence in obtaining better exercise outcomes after discharge. Further, they also obtained higher discharge readiness scores, which constituted a virtuous cycle. As a result, there were significant differences in the Harris score at different time points after discharge between both groups of patients.</p>
<p>The results of this study also validated that the self-care ability of patients was significantly improved 30&#x2009;days after discharge compared with that at discharge. There was no significant difference in the self-care ability at different time points after discharge between both groups. No sufficient evidence was observed to prove that discharge readiness was related to self-care ability at admission, self-care ability at discharge, and changes in self-care ability at 30&#x2009;days after discharge (compared with that before surgery). This indicated that THA could affect the patient&#x2019;s self-care ability, possibly due to the fact that the original symptoms of patients could be resolved within 30&#x2009;days after discharge, which improved the subjective feeling of patients compared with that before surgery and at discharge, thereby improving their self-care ability. From the completion of the surgery to discharge, patients might experience certain stress reactions and postoperative discomfort, such as hip joint pain, due to the influence of surgery. This affected the subjective feeling and self-care ability of these patients, resulting in a lack of significant improvement in their self-care ability before and after discharge. The discharge readiness level of patients was only determined by their readiness to return to society, but their subjective perception or tolerance of hip joint symptoms would not change with the discharge readiness level. Only when it became apparent that hip joint symptoms were mitigated could their self-care ability be improved. This also explained that the discharge readiness level did not affect the self-care ability of these patients. In addition, the changes in time points would not affect the self-care ability of the two groups of patients. Konnyu et al. (<xref ref-type="bibr" rid="ref26">26</xref>) conducted a systematic review of different rehabilitation plans after hip arthroplasty and found that different rehabilitation plans did not affect the self-care ability or quality of life of patients. Sakia et al. (<xref ref-type="bibr" rid="ref27">27</xref>) also investigated hip surface arthroplasty, THA through the anterolateral approach, and THA through the posterolateral approach. They found that there was no significant difference in postoperative self-care ability among these three groups. Ren et al. (<xref ref-type="bibr" rid="ref28">28</xref>) confirmed that early rehabilitation care could significantly improve the self-care ability of older adult patients undergoing hip arthroplasty. Su et al. (<xref ref-type="bibr" rid="ref29">29</xref>) found that the comprehensive care for patients undergoing THA through the anterolateral approach could significantly improve their comfort level during treatment and their self-care ability after surgery. Based on domestic and foreign studies, it could be found that the self-care ability of patients undergoing THA contributed to the recovery of their hip joint functions. However, when patients did not receive relevant intervention on their self-care ability during the perioperative period, their self-care ability changes would not be affected. This could also provide indirect explanations for the relationship between the discharge readiness and the self-care ability of patients in this study. We believe that with a clear understanding of the relationship between discharge readiness and Harris score or self-care ability, and even other influencing factors in patients undergoing total hip replacement surgery, we could contribute to the rapid recovery program, also known as &#x201C;Fast-Track&#x201D; in patients undergoing THA (<xref ref-type="bibr" rid="ref30">30</xref>). This will be beneficial for us to develop rehabilitation plans to similar patients, allowing them to be discharged as soon as possible and return to society.</p>
<p>Of course, there are certain limitations in this study. Firstly, this is a retrospective study, with a relatively low level of evidence in evidence-based medicine. Hence, it is necessary to design prospective studies to validate the results of this study. Secondly, it is a single-center study, which may lead to some bias in the research data. Therefore, it is required to conduct joint multicenter studies in different regions and institutions in the future.</p>
<p>In conclusion, there was a correlation between discharge readiness and changes in Harris score 30&#x2009;days after discharge (compared with that before surgery) in THA patients. The Harris score and self-care ability 30&#x2009;days after discharge were higher than those at the time of discharge. Patients in the higher score group exhibited a higher Harris score compared with those in the lower score group. From the evaluation at different time points after discharge, there was a significant difference in the Harris score between both groups. These results are expected to provide guidance for the physical and mental recovery of patients undergoing THA under the ERAS concept. Furthermore, these findings may contribute to higher diagnosis, treatment, and nursing levels of orthopedic medical staff.</p>
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</body>
<back>
<sec sec-type="data-availability" id="sec14">
<title>Data availability statement</title>
<p>The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.</p>
</sec>
<sec sec-type="ethics-statement" id="sec15">
<title>Ethics statement</title>
<p>The studies involving humans were approved by Ethics Committee of Peking University Shenzhen Hospital. The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study.</p>
</sec>
<sec sec-type="author-contributions" id="sec16">
<title>Author contributions</title>
<p>PL: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing &#x2013; original draft. WC: Data curation, Formal analysis, Methodology, Resources, Software, Writing &#x2013; original draft. YS: Data curation, Formal analysis, Software, Writing &#x2013; original draft. LD: Data curation, Formal analysis, Software, Writing &#x2013; original draft. XQ: Data curation, Software, Writing &#x2013; original draft. HY: Data curation, Formal analysis, Writing &#x2013; original draft. XJ: Data curation, Formal analysis, Writing &#x2013; original draft. ZT: Conceptualization, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing &#x2013; original draft. FY: Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing &#x2013; original draft, Writing &#x2013; review &#x0026; editing.</p>
</sec>
<sec sec-type="funding-information" id="sec17">
<title>Funding</title>
<p>The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was supported by grants from Guangdong Medical Science and Technology Research Funding (No. A2022390), Shenzhen Science and Technology Program (No. JCYJ20220531094401003), Research Foundation of Peking University Shenzhen Hospital (No. LCYJ2020019), National Natural Science Foundation of China (No. 82102568), Shenzhen Key Medical Discipline Construction Fund (No. SZXK023), Shenzhen &#x201C;San-Ming&#x201D; Project of Medicine (No. SZSM202211038), Guangdong Basic and Applied Basic Research Foundation (No. 2022A1515220111; No. 2021A1515012586), and Peking University Shenzhen Hospital Scientific Research Fund (No. KYQD2021099).</p>
</sec>
<sec sec-type="COI-statement" id="sec18">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec sec-type="disclaimer" id="sec19">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
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