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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Med.</journal-id>
<journal-title>Frontiers in Medicine</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Med.</abbrev-journal-title>
<issn pub-type="epub">2296-858X</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fmed.2014.00050</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Medicine</subject>
<subj-group>
<subject>Mini Reviews in Medicine</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>A Different Approach of Dizziness in Older Patients: Away from the Diagnostic Dance between Patient and Physician</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Maarsingh</surname> <given-names>Otto R.</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<xref ref-type="corresp" rid="cor1">&#x0002A;</xref>
<uri xlink:href="http://frontiersin.org/people/u/158221"/>
</contrib>
<contrib contrib-type="author">
<name><surname>Stam</surname> <given-names>Hanneke</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<uri xlink:href="http://frontiersin.org/people/u/158838"/>
</contrib>
<contrib contrib-type="author">
<name><surname>van der Horst</surname> <given-names>Henri&#x000EB;tte E.</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref>
<uri xlink:href="http://frontiersin.org/people/u/159286"/>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup><institution>Department of General Practice and Elderly Care Medicine, VU University Medical Center</institution>, <addr-line>Amsterdam</addr-line>, <country>Netherlands</country></aff>
<aff id="aff2"><sup>2</sup><institution>EMGO Institute for Health and Care Research, VU University Medical Center</institution>, <addr-line>Amsterdam</addr-line>, <country>Netherlands</country></aff>
<author-notes>
<fn fn-type="edited-by"><p>Edited by: Frank Sullivan, University of Toronto, Canada</p></fn>
<fn fn-type="edited-by"><p>Reviewed by: Kees Van Boven, Radboud University Nijmegen, Netherlands; Jos&#x000E9; Luis Ballv&#x000E9;, Hospitalet de Llobregat, Spain</p></fn>
<corresp content-type="corresp" id="cor1">&#x0002A;Correspondence: Otto R. Maarsingh, Department of General Practice and Elderly Care Medicine, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room D528, Amsterdam 1081 BT, Netherlands e-mail: <email>o.maarsingh&#x00040;vumc.nl</email></corresp>
<fn fn-type="other" id="fn001"><p>This article was submitted to Family Medicine and Primary Care, a section of the journal Frontiers in Medicine.</p></fn>
</author-notes>
<pub-date pub-type="epreprint">
<day>04</day>
<month>11</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub">
<day>01</day>
<month>12</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="collection">
<year>2014</year>
</pub-date>
<volume>1</volume>
<elocation-id>50</elocation-id>
<history>
<date date-type="received">
<day>06</day>
<month>07</month>
<year>2014</year>
</date>
<date date-type="accepted">
<day>17</day>
<month>11</month>
<year>2014</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#x000A9; 2014 Maarsingh, Stam and van der Horst.</copyright-statement>
<copyright-year>2014</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<abstract>
<p>Although the etiology of dizziness in older patients differs significantly from that of younger patients, most guidelines on dizziness advocate the same diagnosis-oriented approach for all patients regardless of their age. However, this diagnosis-oriented approach may be insufficient for older patients presenting with dizziness in general practice, because (1) general practitioners are often not able to identify an underlying cause of dizziness, (2) general practitioners regularly identify causes of dizziness that cannot be treated, and (3) general practitioners may identify causes of dizziness for which treatment is available but not desirable. In this article, the authors present a simultaneous diagnosis- and prognosis-oriented approach for older dizzy patients. This approach may enable general practitioners to improve their care for a voluminous group of impaired older patients, even if a diagnosis is not available (yet).</p>
</abstract>
<kwd-group>
<kwd>dizziness</kwd>
<kwd>older people</kwd>
<kwd>prognosis</kwd>
<kwd>diagnosis</kwd>
<kwd>general practice</kwd>
</kwd-group>
<counts>
<fig-count count="1"/>
<table-count count="0"/>
<equation-count count="0"/>
<ref-count count="23"/>
<page-count count="3"/>
<word-count count="2158"/>
</counts>
</article-meta>
</front>
<body>
<p>Dizziness &#x02013; like falling and incontinence &#x02013; is one of the geriatric giants. Thirty percent of people above 65&#x02009;years of age experience some form of dizziness, increasing to 50% in persons above 85&#x02009;years (<xref ref-type="bibr" rid="B1">1</xref>). Nine percent of all persons above 65&#x02009;years visit their general practitioner (GP) at least once a year because of dizziness (<xref ref-type="bibr" rid="B2">2</xref>). The complaint dizziness can lead to severe limitations in daily functioning (<xref ref-type="bibr" rid="B3">3</xref>). Dizziness is also a major risk factor for falling (<xref ref-type="bibr" rid="B4">4</xref>), thus leading to further limitation of activities, fractures, and high healthcare costs (<xref ref-type="bibr" rid="B5">5</xref>).</p>
<p>Although the etiology of dizziness in older patients differs significantly from that of younger patients, most guidelines on dizziness advocate the same diagnosis-oriented approach for all patients regardless of their age. However, this diagnosis-oriented approach may be insufficient for older patients presenting with dizziness. Firstly, GPs are often not able to identify an underlying cause of dizziness [40&#x02013;80% of older dizzy patients in general practice; (<xref ref-type="bibr" rid="B2">2</xref>, <xref ref-type="bibr" rid="B6">6</xref>)]. Secondly, GPs regularly identify causes of dizziness that cannot be treated (e.g., polyneuropathy, 19% of older dizzy patients in general practice) or hardly treated [e.g., orthostatic hypotension, 24% of older dizzy patients; (<xref ref-type="bibr" rid="B7">7</xref>)]. Finally, GPs may identify causes of dizziness for which treatment is available but not desirable [e.g., Epley maneuver for benign paroxysmal positional vertigo in patients with severe cervical arthrosis; (<xref ref-type="bibr" rid="B8">8</xref>)].</p>
<p>When applied to older patients with <italic>chronic</italic> dizziness [70% of older dizzy patients in primary care have a dizziness onset of &#x02265;6&#x02009;months ago; (<xref ref-type="bibr" rid="B7">7</xref>)], the current diagnosis-oriented approach is not only insufficient but may also have negative side-effects. When a GP is not able to identify an underlying cause of dizziness, patient and GP may persist in a diagnostic dance, leading to extensive testing and unnecessary referral (<xref ref-type="bibr" rid="B9">9</xref>, <xref ref-type="bibr" rid="B10">10</xref>). An absent diagnosis and &#x02013; consequently &#x02013; clues for therapeutic interventions may also lead to inappropriate drug prescribing. Data from the Second Dutch National Survey of General Practice (DNSGP-2) show that GPs prescribed ineffective drugs to 10% of dizzy older patients during the first consultation (<xref ref-type="bibr" rid="B11">11</xref>). Eventually, a GP may indulge in therapeutic nihilism: &#x0201C;dizziness comes with age&#x0201D; or &#x0201C;you will have to live with this.&#x0201D;</p>
<p>Previously, other researchers emphasized the limitations of the current diagnosis-oriented approach of dizziness. In 1999, Sloane and Dallara already expressed the need for strategies that more effectively reduce symptoms and dizziness-related disability (<xref ref-type="bibr" rid="B12">12</xref>). In 2000, Tinetti and others suggested that considering dizziness, a geriatric syndrome might lay the groundwork for such an impairment reduction strategy (<xref ref-type="bibr" rid="B3">3</xref>). Geriatric syndromes are multifactorial health conditions that occur when the accumulated effect of impairments in multiple systems renders a person vulnerable to situational challenges. More recently, other researchers supported this concept of dizziness as a geriatric syndrome (<xref ref-type="bibr" rid="B13">13</xref>&#x02013;<xref ref-type="bibr" rid="B16">16</xref>).</p>
<p>When focusing on underlying causes of dizziness, it is easy to neglect individual prognostic differences. Dros and others found that 34% of older dizzy patients in general practice will experience persistent dizziness-related impairment after 6&#x02009;months (<xref ref-type="bibr" rid="B17">17</xref>). They found dizziness-related impairment at baseline [as measured with the Dizziness Handicap Inventory, DHI; (<xref ref-type="bibr" rid="B18">18</xref>)] to be the strongest predictor of persistent dizziness-related impairment. Additionally, they identified seven predictors of persistent dizziness-related impairment, namely (1) dizziness onset of more than 6&#x02009;months ago, (2) dizziness provoked by standing still, (3) associated trouble with walking, (4) polypharmacy, (5) absence of diabetes mellitus (explanation: diabetes may be a marker for attentive medical care), (6) presence of anxiety or depression, and (7) impaired functional mobility (<xref ref-type="bibr" rid="B17">17</xref>). The research group also constructed a seven-item sum score to calculate the probability of persistent dizziness-related impairment (<xref ref-type="bibr" rid="B17">17</xref>). An example, when applying the score calculation in a patient X with chronic dizziness provoked by standing still and associated with walking, using six drugs and having a comorbid depression and impaired functional mobility, the probability of persistent dizziness-related impairment in patient X changes from 34 to 85%. Even if patient X&#x02019;s GP is not able to identify an underlying cause of dizziness (yet), patient X has three predictors of persistent impairment that are amenable to treatment, namely (1) polypharmacy (treatment: medication reduction), (2) depression (psychotherapy and/or antidepressants), and (3) impaired functional mobility (physiotherapy).</p>
<p>For the clinical approach of <italic>chronic</italic> dizziness in older patients in primary care, we would like to suggest to replace the current &#x0201C;serial connection&#x0201D; between diagnosis and prognosis by a &#x0201C;parallel connection,&#x0201D; i.e., the diagnosis-oriented phase and prognosis-oriented phase start at the same time (see Figure <xref ref-type="fig" rid="F1">1</xref>). Currently, GPs are used to focus on prognosis <italic>after</italic> diagnosing a specific disease, for example, investigating the presence of albuminuria &#x02013; as a marker for kidney disease &#x02013; after diagnosing diabetes mellitus. In other words, the prognosis-oriented phase (&#x0201C;is this patient at risk of an unfavorable outcome and, if so, how to improve this outcome?&#x0201D;) follows the diagnosis-oriented phase (&#x0201C;what is the underlying cause of the presented complaint?&#x0201D;). We believe that the suggested &#x0201C;parallel connection&#x0201D; of diagnosis and prognosis is crucial for older dizzy patients in primary care, because many older dizzy patients remain undiagnosed but have clues for impairment reduction (<xref ref-type="bibr" rid="B3">3</xref>, <xref ref-type="bibr" rid="B13">13</xref>, <xref ref-type="bibr" rid="B14">14</xref>).</p>
<fig position="float" id="F1">
<label>Figure 1</label>
<caption><p><bold>Schematic representation of current and suggested approach of chronic dizziness in older patients in general practice (D, diagnosis-oriented phase; P, prognosis-oriented phase)</bold>.</p></caption>
<graphic xlink:href="fmed-01-00050-g001.tif"/>
</fig>
<p>For daily clinical practice, the suggested additional prognosis-oriented approach could imply that a GP tries (1) to estimate if an older dizzy patient is at risk of persistent impairment [by using the DHI and the seven-item sum score; (<xref ref-type="bibr" rid="B17">17</xref>, <xref ref-type="bibr" rid="B18">18</xref>)] and, if so, (2) to identify modifiable predictors of an unfavorable course of dizziness. Examples of previously identified modifiable predictors are impaired functional mobility [treatment: physical exercise or physiotherapy; (<xref ref-type="bibr" rid="B17">17</xref>)], comorbid anxiety [psychotherapy and/or anxiolytics; (<xref ref-type="bibr" rid="B17">17</xref>, <xref ref-type="bibr" rid="B19">19</xref>)], comorbid depression [psychotherapy and/or antidepressants; (<xref ref-type="bibr" rid="B17">17</xref>)], dizziness due to psychiatric causes [psychotherapy and/or psychotropic drugs; (<xref ref-type="bibr" rid="B20">20</xref>)], polypharmacy [medication reduction; (<xref ref-type="bibr" rid="B17">17</xref>)], and the presence of avoidance [cognitive behavioral therapy; (<xref ref-type="bibr" rid="B21">21</xref>)].</p>
<p>Finally, we do not want to advocate diagnostic nihilism. The suggested approach should not be at the expense of a thorough diagnostic evaluation. Benign paroxysmal positional vertigo, for example, is a cause of dizziness in older patients that can be easily diagnosed [history taking and Hallpike maneuver; (<xref ref-type="bibr" rid="B22">22</xref>)] and effectively treated [Epley maneuver; (<xref ref-type="bibr" rid="B8">8</xref>, <xref ref-type="bibr" rid="B23">23</xref>)]. The clinical approach of dizziness in older patients requires personalized care, though, in which it is necessary to find a delicate balance between excessive testing and diagnostic nihilism.</p>
<sec id="S1">
<title>Conclusion</title>
<p>The current diagnosis-oriented approach does not suit older patients presenting with dizziness. A simultaneous diagnosis- and prognosis-oriented approach for older dizzy patients may enable GPs to improve their care for a voluminous group of impaired older patients, even if a diagnosis is not available (yet). Hopefully, such an approach will not only improve the patient&#x02019;s quality of life, but also reduce inappropriate drug prescribing and unnecessary referral.</p>
</sec>
<sec id="S2">
<title>Conflict of Interest Statement</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
</body>
<back>
<ack>
<p>The first author (Otto R. Maarsingh) was supported by an individual grant of the Stichting Beroepsopleiding Huisartsen (SBOH) in The Netherlands.</p>
</ack>
<ref-list>
<title>References</title>
<ref id="B1"><label>1</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Jonsson</surname> <given-names>R</given-names></name> <name><surname>Sixt</surname> <given-names>E</given-names></name> <name><surname>Landahl</surname> <given-names>S</given-names></name> <name><surname>Rosenhall</surname> <given-names>U</given-names></name></person-group>. <article-title>Prevalence of dizziness and vertigo in an urban elderly population</article-title>. <source>J Vestib Res</source> (<year>2004</year>) <volume>14</volume>:<fpage>47</fpage>&#x02013;<lpage>52</lpage>.<pub-id pub-id-type="pmid">15156096</pub-id></citation></ref>
<ref id="B2"><label>2</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Maarsingh</surname> <given-names>OR</given-names></name> <name><surname>Dros</surname> <given-names>J</given-names></name> <name><surname>Schellevis</surname> <given-names>FG</given-names></name> <name><surname>van Weert</surname> <given-names>HC</given-names></name> <name><surname>Bindels</surname> <given-names>PJ</given-names></name> <name><surname>van der Horst</surname> <given-names>HE</given-names></name></person-group>. <article-title>Dizziness reported by elderly patients in family practice: prevalence, incidence, and clinical characteristics</article-title>. <source>BMC Fam Pract</source> (<year>2010</year>) <volume>11</volume>:<fpage>2</fpage>.<pub-id pub-id-type="doi">10.1186/1471-2296-11-2</pub-id><pub-id pub-id-type="pmid">20064231</pub-id></citation></ref>
<ref id="B3"><label>3</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Tinetti</surname> <given-names>ME</given-names></name> <name><surname>Williams</surname> <given-names>CS</given-names></name> <name><surname>Gill</surname> <given-names>TM</given-names></name></person-group>. <article-title>Dizziness among older adults: a possible geriatric syndrome</article-title>. <source>Ann Intern Med</source> (<year>2000</year>) <volume>132</volume>(<issue>5</issue>):<fpage>337</fpage>&#x02013;<lpage>44</lpage>.<pub-id pub-id-type="doi">10.7326/0003-4819-132-5-200003070-00026</pub-id></citation></ref>
<ref id="B4"><label>4</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Agrawal</surname> <given-names>Y</given-names></name> <name><surname>Carey</surname> <given-names>JP</given-names></name> <name><surname>La Santina</surname> <given-names>CC</given-names></name> <name><surname>Schubert</surname> <given-names>MC</given-names></name> <name><surname>Minor</surname> <given-names>LB</given-names></name></person-group>. <article-title>Disorders of balance and vestibular function in US adults: data from the National Health and Nutrition Examination Survey, 2001-2004</article-title>. <source>Arch Intern Med</source> (<year>2009</year>) <volume>169</volume>:<fpage>938</fpage>&#x02013;<lpage>44</lpage>.<pub-id pub-id-type="doi">10.1001/archinternmed.2009.66</pub-id><pub-id pub-id-type="pmid">19468085</pub-id></citation></ref>
<ref id="B5"><label>5</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Scuffham</surname> <given-names>P</given-names></name> <name><surname>Chaplin</surname> <given-names>S</given-names></name> <name><surname>Legood</surname> <given-names>R</given-names></name></person-group>. <article-title>Incidence and costs of unintentional falls in older people in the United Kingdom</article-title>. <source>J Epidemiol Community Health</source> (<year>2003</year>) <volume>57</volume>:<fpage>740</fpage>&#x02013;<lpage>4</lpage>.<pub-id pub-id-type="doi">10.1136/jech.57.9.740</pub-id><pub-id pub-id-type="pmid">12933783</pub-id></citation></ref>
<ref id="B6"><label>6</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kruschinski</surname> <given-names>C</given-names></name> <name><surname>Kersting</surname> <given-names>M</given-names></name> <name><surname>Breull</surname> <given-names>A</given-names></name> <name><surname>Kochen</surname> <given-names>MM</given-names></name> <name><surname>Koschack</surname> <given-names>J</given-names></name> <name><surname>Hummers-Pradier</surname> <given-names>E</given-names></name></person-group>. <article-title>Frequency of dizziness-related diagnoses and prescriptions in a general practice database</article-title>. <source>Z Evid Fortbild Qual Gesundhwes</source> (<year>2008</year>) <volume>102</volume>(<issue>5</issue>):<fpage>313</fpage>&#x02013;<lpage>9</lpage>.<pub-id pub-id-type="doi">10.1016/j.zefq.2008.05.001</pub-id><pub-id pub-id-type="pmid">19006919</pub-id></citation></ref>
<ref id="B7"><label>7</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Maarsingh</surname> <given-names>OR</given-names></name> <name><surname>Dros</surname> <given-names>J</given-names></name> <name><surname>Schellevis</surname> <given-names>FG</given-names></name> <name><surname>van Weert</surname> <given-names>HC</given-names></name> <name><surname>van der Windt</surname> <given-names>DA</given-names></name> <name><surname>Ter Riet</surname> <given-names>G</given-names></name> <etal/></person-group> <article-title>Causes of persistent dizziness in elderly patients in primary care</article-title>. <source>Ann Fam Med</source> (<year>2010</year>) <volume>8</volume>(<issue>3</issue>):<fpage>196</fpage>&#x02013;<lpage>205</lpage>.<pub-id pub-id-type="doi">10.1370/afm.1116</pub-id><pub-id pub-id-type="pmid">20458102</pub-id></citation></ref>
<ref id="B8"><label>8</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Hilton</surname> <given-names>MP</given-names></name> <name><surname>Pinder</surname> <given-names>DK</given-names></name></person-group>. <article-title>The Epley (canalith repositioning) manoeuvre for benign paroxysmal positional vertigo (2004, update 2010)</article-title>. <source>Cochrane Database Syst Rev</source> (<year>2010</year>).<pub-id pub-id-type="doi">10.1002/14651858.CD003162.pub2</pub-id></citation></ref>
<ref id="B9"><label>9</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Van der Weijden</surname> <given-names>T</given-names></name> <name><surname>Van Bokhoven</surname> <given-names>MA</given-names></name> <name><surname>Dinant</surname> <given-names>GJ</given-names></name> <name><surname>Van Hasselt</surname> <given-names>CM</given-names></name> <name><surname>Grol</surname> <given-names>RP</given-names></name></person-group>. <article-title>Understanding laboratory testing in diagnostic uncertainty: a qualitative study in general practice</article-title>. <source>Br J Gen Pract</source> (<year>2002</year>) <volume>52</volume>(<issue>485</issue>):<fpage>974</fpage>&#x02013;<lpage>80</lpage>.<pub-id pub-id-type="pmid">12528582</pub-id></citation></ref>
<ref id="B10"><label>10</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Van der Weijden</surname> <given-names>T</given-names></name> <name><surname>Van Velzen</surname> <given-names>M</given-names></name> <name><surname>Dinant</surname> <given-names>GJ</given-names></name> <name><surname>Van Hasselt</surname> <given-names>CM</given-names></name> <name><surname>Grol</surname> <given-names>RP</given-names></name></person-group>. <article-title>Unexplained complaints in general practice: prevalence, patients&#x02019; expectations, and professionals&#x02019; test-ordering behavior</article-title>. <source>Med Decis Making</source> (<year>2003</year>) <volume>23</volume>(<issue>3</issue>):<fpage>226</fpage>&#x02013;<lpage>31</lpage>.<pub-id pub-id-type="doi">10.1177/0272989X03023003004</pub-id><pub-id pub-id-type="pmid">12809320</pub-id></citation></ref>
<ref id="B11"><label>11</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Maarsingh</surname> <given-names>OR</given-names></name> <name><surname>Schellevis</surname> <given-names>FG</given-names></name> <name><surname>van der Horst</surname> <given-names>HE</given-names></name></person-group>. <article-title>Looks vestibular: irrational prescribing of antivertiginous drugs for older dizzy patients in general practice</article-title>. <source>Br J Gen Pract</source> (<year>2012</year>) <volume>62</volume>(<issue>603</issue>):<fpage>518</fpage>&#x02013;<lpage>20</lpage>.<pub-id pub-id-type="doi">10.3399/bjgp12X656757</pub-id></citation></ref>
<ref id="B12"><label>12</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Sloane</surname> <given-names>PD</given-names></name> <name><surname>Dallara</surname> <given-names>J</given-names></name></person-group>. <article-title>Clinical research and geriatric dizziness: the blind men and the elephant</article-title>. <source>J Am Geriatr Soc</source> (<year>1999</year>) <volume>47</volume>:<fpage>113</fpage>&#x02013;<lpage>4</lpage>.</citation></ref>
<ref id="B13"><label>13</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Gassmann</surname> <given-names>KG</given-names></name> <name><surname>Rupprecht</surname> <given-names>R</given-names></name></person-group>. <article-title>Dizziness in an older community dwelling population: a multifactorial syndrome</article-title>. <source>J Nutr Health Aging</source> (<year>2009</year>) <volume>13</volume>:<fpage>278</fpage>&#x02013;<lpage>82</lpage>.<pub-id pub-id-type="doi">10.1007/s12603-009-0073-2</pub-id><pub-id pub-id-type="pmid">19262968</pub-id></citation></ref>
<ref id="B14"><label>14</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Gomez</surname> <given-names>F</given-names></name> <name><surname>Curcio</surname> <given-names>CL</given-names></name> <name><surname>Duque</surname> <given-names>G</given-names></name></person-group>. <article-title>Dizziness as a geriatric condition among rural community-dwelling older adults</article-title>. <source>J Nutr Health Aging</source> (<year>2011</year>) <volume>15</volume>:<fpage>490</fpage>&#x02013;<lpage>7</lpage>.<pub-id pub-id-type="doi">10.1007/s12603-011-0050-4</pub-id><pub-id pub-id-type="pmid">21623472</pub-id></citation></ref>
<ref id="B15"><label>15</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>de Moraes</surname> <given-names>SA</given-names></name> <name><surname>Soares</surname> <given-names>WJ</given-names></name> <name><surname>Ferriolli</surname> <given-names>E</given-names></name> <name><surname>Perracini</surname> <given-names>MR</given-names></name></person-group>. <article-title>Prevalence and correlates of dizziness in community-dwelling older people: a cross sectional population based study</article-title>. <source>BMC Geriatr</source> (<year>2013</year>) <volume>13</volume>:<fpage>4</fpage>.<pub-id pub-id-type="doi">10.1186/1471-2318-13-4</pub-id><pub-id pub-id-type="pmid">23290128</pub-id></citation></ref>
<ref id="B16"><label>16</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Stevens</surname> <given-names>KN</given-names></name> <name><surname>Lang</surname> <given-names>IA</given-names></name> <name><surname>Guralnik</surname> <given-names>JM</given-names></name> <name><surname>Melzer</surname> <given-names>D</given-names></name></person-group>. <article-title>Epidemiology of balance and dizziness in a national population: findings from the English Longitudinal Study of Ageing</article-title>. <source>Age Ageing</source> (<year>2008</year>) <volume>37</volume>:<fpage>300</fpage>&#x02013;<lpage>5</lpage>.<pub-id pub-id-type="doi">10.1093/ageing/afn019</pub-id><pub-id pub-id-type="pmid">18270246</pub-id></citation></ref>
<ref id="B17"><label>17</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Dros</surname> <given-names>J</given-names></name> <name><surname>Maarsingh</surname> <given-names>OR</given-names></name> <name><surname>van der Windt</surname> <given-names>DA</given-names></name> <name><surname>Oort</surname> <given-names>FJ</given-names></name> <name><surname>ter Riet</surname> <given-names>G</given-names></name> <name><surname>de Rooij</surname> <given-names>SE</given-names></name> <etal/></person-group> <article-title>Functional prognosis of dizziness in older primary care patients: a prospective cohort study</article-title>. <source>J Am Geriatr Soc</source> (<year>2012</year>) <volume>60</volume>(<issue>12</issue>):<fpage>2263</fpage>&#x02013;<lpage>9</lpage>.<pub-id pub-id-type="doi">10.1111/jgs.12031</pub-id><pub-id pub-id-type="pmid">23231549</pub-id></citation></ref>
<ref id="B18"><label>18</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Jacobson</surname> <given-names>GP</given-names></name> <name><surname>Newman</surname> <given-names>CW</given-names></name></person-group>. <article-title>The development of the Dizziness Handicap Inventory</article-title>. <source>Arch Otolaryngol Head Neck Surg</source> (<year>1990</year>) <volume>116</volume>(<issue>4</issue>):<fpage>424</fpage>&#x02013;<lpage>7</lpage>.<pub-id pub-id-type="doi">10.1001/archotol.1990.01870040046011</pub-id><pub-id pub-id-type="pmid">2317323</pub-id></citation></ref>
<ref id="B19"><label>19</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bailey</surname> <given-names>KE</given-names></name> <name><surname>Sloane</surname> <given-names>PD</given-names></name> <name><surname>Mitchell</surname> <given-names>M</given-names></name> <name><surname>Preisser</surname> <given-names>J</given-names></name></person-group>. <article-title>Which primary care patients with dizziness will develop persistent impairment?</article-title> <source>Arch Fam Med</source> (<year>1993</year>) <volume>2</volume>(<issue>8</issue>):<fpage>847</fpage>&#x02013;<lpage>52</lpage>.<pub-id pub-id-type="doi">10.1001/archfami.2.8.847</pub-id><pub-id pub-id-type="pmid">8111514</pub-id></citation></ref>
<ref id="B20"><label>20</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kroenke</surname> <given-names>K</given-names></name> <name><surname>Lucas</surname> <given-names>C</given-names></name> <name><surname>Rosenberg</surname> <given-names>ML</given-names></name> <name><surname>Scherokman</surname> <given-names>B</given-names></name> <name><surname>Herbers</surname> <given-names>JE</given-names></name></person-group>. <article-title>One-year outcome for patients with a chief complaint of dizziness</article-title>. <source>J Gen Intern Med</source> (<year>1994</year>) <volume>9</volume>(<issue>12</issue>):<fpage>684</fpage>&#x02013;<lpage>9</lpage>.<pub-id pub-id-type="doi">10.1007/BF02599010</pub-id><pub-id pub-id-type="pmid">7876951</pub-id></citation></ref>
<ref id="B21"><label>21</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Nazareth</surname> <given-names>I</given-names></name> <name><surname>Yardley</surname> <given-names>L</given-names></name> <name><surname>Owen</surname> <given-names>N</given-names></name> <name><surname>Luxon</surname> <given-names>L</given-names></name></person-group>. <article-title>Outcome of symptoms of dizziness in a general practice community sample</article-title>. <source>Fam Pract</source> (<year>1999</year>) <volume>16</volume>(<issue>6</issue>):<fpage>616</fpage>&#x02013;<lpage>8</lpage>.<pub-id pub-id-type="doi">10.1093/fampra/16.6.616</pub-id><pub-id pub-id-type="pmid">10625139</pub-id></citation></ref>
<ref id="B22"><label>22</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Barraclough</surname> <given-names>K</given-names></name> <name><surname>Bronstein</surname> <given-names>A</given-names></name></person-group>. <article-title>Vertigo</article-title>. <source>BMJ</source> (<year>2009</year>) <volume>339</volume>:<fpage>b3493</fpage>.<pub-id pub-id-type="doi">10.1136/bmj.b3493</pub-id></citation></ref>
<ref id="B23"><label>23</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Glasziou</surname> <given-names>P</given-names></name> <name><surname>Heneghan</surname> <given-names>C</given-names></name></person-group>. <article-title>Epley and the slow boat from research to practice</article-title>. <source>Evid Based Med</source> (<year>2008</year>) <volume>13</volume>(<issue>2</issue>):<fpage>34</fpage>&#x02013;<lpage>5</lpage>.<pub-id pub-id-type="doi">10.1136/ebm.13.2.34-a</pub-id></citation></ref>
</ref-list>
</back>
</article>