Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering dermatosis, which typically develops in patients older than 70 years (1). The global incidence of BP was reported as 0.0419 per 1000 person-years (2). The severity of itch and cutaneous lesions significantly disturbs the quality of life in affected patients. BP is mediated by tissue-bound and circulating autoantibodies directed against BP antigen 180 (BP180) and BP antigen 230 (BP230) which are hemidesmosomes proteins (1). Recent evidence has linked the pathogenesis of BP to Th2 inflammation, and this relationship is mediated by Th2-related cytokines, such as interleukin(IL)-4 and IL-13 which are found elevated in the skin, sera and blister fluid of BP patients. Studies identified that these Th2-related cytokines could induce IgE production in B cells contributing to the loss of tolerance against BP antigens and eosinophilia (3).

Dupilumab inhibits both IL-4 and IL-13 signaling by blocking the IL-4 receptor alpha subunit. Dual blockade of IL-4 and IL-13 elicits two key anti-inflammatory effects: it not only impedes the migration and subsequent recruitment of eosinophils to inflammatory foci, but also restricts B-cell proliferation and class-switching, ultimately resulting in decreased IgE production (3). Decreased eosinophil infiltration at inflammatory sites markedly mitigates pruritus driven by eosinophil degranulation. Concurrently, diminished IgE synthesis not only abrogates its T-cell activation-promoting capacity, but also attenuates degranulation of eosinophils and mast cells, leading to amelioration of erythema, blisters and pruritus in patients (4).

Systemic corticosteroids are widely used in the treatment of bullous pemphigoid, which is recommended by several clinical practice guidelines (1, 5, 6). However, long-term application of corticosteroids may cause serious side effects, especially in elderly population. New therapeutic pharmacologic biologic agents such as dupilumab can selectively inhibit inflammatory cascade and it may be a safer and effective treatment option. Satisfactory therapeutic effect of dupilumab in BP has been observed in several studies (please refer to the Supplementary Table S2).

To date, there remains a paucity of meta-analyses addressing dupilumab use in BP. No randomized controlled trial (RCT) on dupilumab for BP has been published up till now. Additionally, the potential severity of the disease poses significant challenges for conducting randomized placebo-controlled trials in this patient population. Based on the clinical studies that have been published so far, we conducted a single-arm meta-analysis assessing the efficacy and safety of dupilumab in BP to provide comprehensive evidence for clinical practice.

The systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (7). The study protocol has been registered with PROSPERO (CRD420251048550).

This systematic review examines the effectiveness and safety of dupilumab in BP treatment.

For the treatment of bullous pemphigoid, systemic corticosteroids represent a widely used therapeutic option, and this approach is recommended in several clinical practice guidelines (1, 5, 6). However, the long-term use of systemic corticosteroids is also associated with relapse and increased mortality. Off-label immunosuppressants (e.g. methotrexate, azathioprine, mycophenolate mofetil) and antibiotics with anti-inflammatory properties (e.g. doxycycline, minocycline) can also be used. However, all of them are associated with various side effects and limited therapeutic efficacy.

The mechanisms of BP development are not completely understood. However, mounting evidence indicates that a type 2 inflammatory response may play a key role in BP development. Studies demonstrate elevated levels of the type 2 cytokines IL-4, IL-5 and IL-13, elevated levels of the chemokine eotaxin-1 and greater numbers of eosinophils in BP lesions and peripheral blood as well as increased serum IgE in patients with BP (30). Dupilumab, a fully humanized monoclonal antibody, can block the shared receptor component for IL-4 and IL-13 which are key and central drivers for type 2 inflammation in multiple diseases.

Given these findings, dupilumab may be effective in BP. Several observational studies explored the use of dupilumab in BP. Cao et al. conducted a systemic review using descriptive statistics exploring efficiency of biologic treatment in BP in 2022 (31). In this systemic review, dupilumab led to complete remission in 66.7% (n=24/36) and partial remission in 19.4% (n=7/36) of patients without any reported adverse events in the 36 patients from 11 studies (including 7 case reports) included (31). What’s more, Abduelmula et al. also conducted a descriptive systemic review in 2022 (32). Abduelmula et al. included 39 patients from 12 studies (including 8 case reports) using dupilumab with/without other systemic therapy in BP, leading to complete remission in 82.1% (n=32/39) of patients (32). Previous reviews were systemic review using descriptive statistics which didn’t apply meta-analysis of treatment outcomes. Reporting only a single value of “overall effective rate” fails to reflect the impact of inter-study heterogeneity on the results. Our study applied weighted pooled analysis of “effective rate” from different studies and excluded studies with excessively small sample sizes (n<5)to control the quality of included studies. Meta-analysis can report standardized effect sizes and 95% confidence intervals (95% CI) so as to reflect the relative differences in treatment efficacy and the precision of the results.

Given the limited studies in this field, Nunes da Silva et al. performed a meta-analysis of comparative studies of dupilumab combined with corticosteroids and conventional corticosteroid therapy alone in patients with moderate-to-severe bullous pemphigoid (33). This meta-analysis included 127 patients from 4 non-randomized studies, demonstrating dupilumab combined with corticosteroids a greater reduction in BPDAI compared with patients who received conventional therapy (33).

Results from our study are consistent with previous reports. Our study included more recent studies from 2022 to 2025, and quantitatively synthesized data from these researches (including 23 retrospective studies and 1 case series). Pooled analysis revealed a complete response rate of 68% (95% CI 60%∼78%) and disease control rate of 95% (95% CI 92%~98%) in BP treated with dupilumab with/without other systemic therapy.

At present, dupilumab has no indication for bullous pemphigoid, and its clinical efficacy has not been verified in large-sample randomized controlled trials (RCTs). Therefore, it is often used in combination with oral glucocorticoids, immunosuppressants, or other therapies in clinical practice. However, in the studies included in our analysis, a subset of patients received dupilumab as the sole systemic therapeutic agent due to multiple factors such as elderly age or comorbidities, yet still achieved favorable clinical outcomes. Complete response rate achieved 63% (95% CI 49%∼81%) in patients with dupilumab without other systemic therapy.

Furthermore, we observed that 17.9% (n=97/541) of patients experienced adverse events (AEs), while most AEs were mild and did not lead to treatment discontinuation. Some of the AEs such as diabetes, osteoporosis and deep vein thrombosis are considered more related to concomitant use of systemic corticosteroids. Dupilumab generally have a strong safety profile for the treatment of BP.

Meanwhile, the first randomized controlled clinical trial (NCT04206553), designed to investigate the efficacy and safety of dupilumab in patients with BP is in progress (34). The results of this study will provide more information for the use of dupilumab in BP.

This study should be interpreted with several limitations. Information on specific demographic characteristics is not available for certain studies which is marked as “NR” in Table 1, Supplementary Table S2. If a study didn’t report data on a specific demographic characteristic, the data from that study shall be excluded from the descriptive statistics of this demographic characteristic. As a result, there may be a discrepancy between the statistical data and the actual baseline situation.

Moderate heterogeneity may affect the reliability of the results. The included studies were sourced from 7 distinct countries and encompassed multiple ethnic populations, thus introducing potential demographic heterogeneity. In addition, it should be noted that 408 patients (69.5%) among the included subjects were concurrently receiving other systemic therapies. Besides, efficacy assessments across the included studies were based on investigator-reported outcomes, and inter-investigator variability may have existed in the evaluation of cutaneous symptoms including erythema, vesiculation and pruritus. Finally, the included clinical studies varied in follow-up duration, which may also have resulted in differences in the observation of treatment efficacy and adverse events.

What’s more, publication bias is a common concern undermining the accuracy of meta-analyses. Studies with positive results are more likely to be published, while those with negative results may fail to be submitted or accepted. We plotted the funnel plot to assess the potential publication bias. As shown in Supplementary files Figures S1-S3, funnel plot asymmetry observed in this study suggests the potential non-publication of small-sample studies with negative findings. More large-sample, high-quality clinical studies should be performed in this field to further confirm the therapeutic efficacy of dupilumab.

No randomized controlled trials have yet been published in this field. Published studies are mostly single-center with limited sample size. And limited data on BP treated with dupilumab monotherapy is available. These limitations highlight the need for future studies to better address these issues.

This meta-analysis highlights the efficacy and safety of dupilumab in BP treatment, offering evidence for future clinical application. Future randomized controlled trials and well-designed observational studies with larger sample size are required to provide higher level evidence-based support.