AUTHOR=Dong Xingwang , Fu Xiaobao , Zhang Hanghao , Ma Yingjun , Wang Cheng , Li Ye , Zhang Su 

TITLE=Durable complete response to PD-1 inhibitor in vesical calculus-associated squamous cell carcinoma: a case report

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1688443

DOI=10.3389/fimmu.2025.1688443

ISSN=1664-3224

ABSTRACT=BackgroundBladder squamous cell carcinoma (SCC) is a rare histological subtype of bladder cancer (1%–5% of cases), with radical cystectomy as the primary recommended treatment. However, evidence for neoadjuvant/adjuvant chemotherapy or immunotherapy remains limited, especially for calculus-associated SCC.Case presentationA 45-year-old male with vesical calculus-associated bladder SCC refused surgery and radiotherapy, and discontinued gemcitabine-cisplatin chemotherapy due to severe toxicity. He received tislelizumab (programmed death-1/PD-1 inhibitor, 200 mg q3w) and achieved a complete response (CR) after 8 cycles. Suprapubic cystolithotomy was safely performed during immunotherapy, and no tumor recurrence was observed for >24 months. Throughout the entire immunotherapy course, no severe immune-related adverse events occurred.ConclusionTislelizumab monotherapy may be a viable option for surgery-ineligible or chemotherapy-intolerant calculus-associated bladder SCC. Definitive stone removal under immunological tumor control is feasible, supporting further exploration of PD-1 inhibitors in this rare subtype.