AUTHOR=Qin Ziwen , Liu Wenjuan , Huang Chuanjun , Zhang Wei 

TITLE=Metabolic reprogramming of macrophages in chronic obstructive pulmonary disease

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1684075

DOI=10.3389/fimmu.2025.1684075

ISSN=1664-3224

ABSTRACT=Chronic obstructive pulmonary disease (COPD) is currently one of the major causes of death and hospitalization globally. Pulmonary inflammation and oxidative stress are considered important mechanisms underlying the disease. Recent studies have indicated that the metabolic processes of immune cells in COPD, notably alveolar macrophages (AMs), may undergo significant alterations, exhibiting distinct metabolic characteristics related to their functional state and polarization phenotype. This phenomenon is known as the immunometabolic reprogramming of macrophages. In this article, we review the polarization phenotype and metabolic characteristics of macrophages in COPD, as well as the mechanisms affecting macrophage metabolism, and discuss the potential significance of pathways targeting immunometabolism of AMs in the treatment of COPD.