AUTHOR=Xing Xiaokang , Wang Qianwen , Zhang Yueyue , Zhang Ge 

TITLE=Prognostic value of presepsin in sepsis and septic shock: a meta-analysis

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1680877

DOI=10.3389/fimmu.2025.1680877

ISSN=1664-3224

ABSTRACT=BackgroundPresepsin, an innate immune activation biomarker, shows potential for predicting the prognosis of sepsis, but its predictive accuracy remains unclear. This meta-analysis aims to evaluate its efficiency for predicting the risk of mortality in sepsis and septic shock.MethodsPer PRISMA guidelines, four databases were searched until January 2025. Sixteen observational studies with 2,066 patients were included. Pooled sensitivity, specificity, DOR, and AUC were calculated using bivariate random-effects models. The sources of heterogeneity were explored via subgroup analyses and meta-regression. Study quality was assessed with QUADAS-2.ResultsPresepsin showed moderate accuracy for predicting the risk of mortality (pooled AUC 0.80, 95% CI: 0.76-0.83). The pooled sensitivity and specificity were 76% (95% CI: 69-82%) and 70% (95% CI: 59-78%), respectively. Sensitivity was notably higher in patients with septic shock (90%) compared to those with sepsis (75%), whereas specificity was comparatively lower (50% vs. 77%). Substantial heterogeneity stemmed from threshold variability and geographic differences (particularly in Korean cohorts). Prospective studies had higher sensitivity (80%) than retrospective studies (60%). No publication bias was detected.ConclusionsPresepsin is a pragmatic biomarker for predicting the risk of mortality, with enhanced sensitivity in septic shock. Presepsin may be integrated into clinical decision-making for early intervention.Systematic Review Registration
PROSPERO, identifier CRD42025639268.