AUTHOR=Chen Xinru , Liu Xinyu , Xu Jiaqi , Zhu Xingyu , Liu Bingyao , Yang Xinhao , Cong Ge , Lin Xiaoyan , Chong Wei , Chen Hao 

TITLE=The inspiration of methyltransferase in RNA methylation modification for targeted therapy of malignant tumors

JOURNAL=Frontiers in Immunology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1663423

DOI=10.3389/fimmu.2025.1663423

ISSN=1664-3224

ABSTRACT=RNA methylation modification has always been a research hotspot. RNA methylation modification can regulate processes such as transcription, translation, splicing, stability, and degradation of RNA, in which effector proteins play an important role, including ‘writers’, ‘erasers’, and ‘readers’. There are various types of proteins involved in cancer progression, and in recent years, research on their mechanisms of action has been increasing, providing new ideas for targeted cancer therapy. By regulating the expression of related genes and affecting signaling pathways, protein writing plays a role in promoting or inhibiting cancer in the proliferation, invasion, migration, and metastasis of different tumors, providing direction for the treatment of malignant tumors. This article reviews the mechanisms of common RNA methylation modified writers and their prospects in targeted cancer therapy.