Front. Immunol. Frontiers in Immunology Front. Immunol. 1664-3224 Frontiers Media S.A. 10.3389/fimmu.2025.1629629 Immunology Correction Corrigendum: 17β-Estradiol promotes trained immunity in female against sepsis via regulating nucleus translocation of RelB Sun Zhiheng 1 Pan Yuchen 1 Qu Junxing 1 Xu Yujun 1 Dou Huan 1 2 * Hou Yayi 1 2 * 1 The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing, China 2 Jiangsu Key Laboratory of Molecular Medicine, Division of Immunology, Medical School, Nanjing University, Nanjing, China

Edited and Reviewed by: Francesca Granucci, University of Milano-Bicocca, Italy

*Correspondence: Huan Dou, douhaun@nju.edu.cn; Yayi Hou, yayihou@nju.edu.cn

13 06 2025 2025 16 1629629 16 05 2025 29 05 2025 Copyright © 2025 Sun, Pan, Qu, Xu, Dou and Hou 2025 Sun, Pan, Qu, Xu, Dou and Hou

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 A Corrigendum on 17β-Estradiol promotes trained immunity in female against sepsis via regulating nucleus translocation of RelB By Sun Z, Pan Y, Qu J, Xu Y, Dou H and Hou Y (2020). Front. Immunol. 11:1591. doi: 10.3389/fimmu.2020.01591 estradiol gender difference macrophages sepsis trained immunity section-in-acceptance Molecular Innate Immunity

In the original article, there was a mistake in Figure 6F as published. The incorrect flow-cytometry results pictures were used in E2+TI+LPS group due to the inconsistent use of gating strategy and the misuse of the same picture. The corrected Figure 6F appears below.

E2 is verified to facilitate trained immunity in primary BMDMs from female and male mice. (A) In vitro trained immunity model for BMDMs. (B) Flow cytometry was used for testing the purity of BMDMs induced by in vitro culture. (C) The mRNA levels of TNFα and IL-6 in male/female BMDMs were detected by qPCR to determine the different intensity of trained immunity between genders. (D) The protein concentrations of TNFα and IL-6 from the supernatant from male/female BMDM cultures were detected by ELISA to determine the different intensity of trained immunity between genders. (E) E2 activated hallmarks of trained immunity, such as Akt, 4EBP1, and S6 by western blot. (F) E2 promoted M1 polarization in TI + LPS group from male and female mice. Meanwhile, E2 maintained the M2 polarization to inhibit the effect of TI (n ≥ 3/group). #p < 0.05, ##p < 0.01, and ###p < 0.001, paired Student’s t-test comparing β-glucan + LPS group and LPS group. *p < 0.05, **p < 0.01, and ***p < 0.001, paired Student's t-test comparing with control group. ^^p < 0.01, paired Student’s t-test comparing between β-glucan + LPS groups with or without E2.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

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