Front. Immunol. Frontiers in Immunology Front. Immunol. 1664-3224 Frontiers Media S.A. 10.3389/fimmu.2025.1595885 Immunology Correction Corrigendum: Extracellular vesicles from human breast cancer-resistant cells promote acquired drug resistance and pro-inflammatory macrophage response Santos Patrick 1 Rezende Caroline P. 1 Piraine Renan 1 Oliveira Bianca 1 Ferreira Francielle B. 1 Carvalho Vinicius S. 2 Calado Rodrigo T. 2 Pellegrini Matteo 3 Almeida Fausto 1 * 1 Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil 2 Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil 3 Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA, United States

Edited and Reviewed by: Anirban Ganguly, All India Institute of Medical Sciences Deoghar, India

*Correspondence: Fausto Almeida, fbralmeida@usp.br

16 04 2025 2025 16 1595885 18 03 2025 04 04 2025 Copyright © 2025 Santos, Rezende, Piraine, Oliveira, Ferreira, Carvalho, Calado, Pellegrini and Almeida 2025 Santos, Rezende, Piraine, Oliveira, Ferreira, Carvalho, Calado, Pellegrini and Almeida

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 A Corrigendum on Extracellular vesicles from human breast cancer-resistant cells promote acquired drug resistance and pro-inflammatory macrophage response by Santos P, Rezende CP, Piraine R, Oliveira B, Ferreira FB, Carvalho VS, Calado RT, Pellegrini M and Almeida F (2024). Front. Immunol. 15:1468229. doi: 10.3389/fimmu.2024.1468229 chemoresistance tamoxifen doxorubicin immunomodulation membrane transporters Conselho Nacional de Desenvolvimento Científico e Tecnológico10.13039/501100003593 Fundação de Amparo à Pesquisa do Estado de São Paulo10.13039/501100001807 section-in-acceptance Cancer Immunity and Immunotherapy

In the published article, there was an error in Figure 6 as published. In panel A and B of Figure 6 , the color in the graph legend corresponding to MCF-7 and MDA-MB-231 sensitive EVs should be in grey, not in blue. The corrected Figure 6 and its caption “Figure 6. Resistant extracellular vesicles (EVs) induce the upregulation of genes associated with acquired drug resistance and increase the sensitive cells’ survivability. The quantification of several genes by quantitative polymerase chain reaction (qPCR) of (A) sensitive MCF-7 exposed to tamoxifen-resistant (TAM-R) and doxorubicin-resistant (DOX-R) EVs. (B) The gene expression level of sensitive MDA-MB-231 cells exposed to TAM-R and DOX-R. (C) The apoptotic rate by annexin V/propidium iodide labeling in sensitive MCF-7 and sensitive MDA-MB-231 previously exposed to resistant EVs and treated with TAM and DOX. (D) Representative images and the clonogenic surviving fraction of MCF-7 cells previously exposed to TAM-R and (E) DOX-R EVs treated with the respective drug. (F) Representative images and the clonogenic surviving fraction of MDA-MB-231 cells previously exposed to TAM-R and (G) DOX-R EVs treated with the respective drug. Values are displayed as the mean ± standard deviation from three independent experiments. The asterisks indicate a significant difference between TAM-R EVs or DOX-R EVs exposure compared to sensitive EV effects (unpaired t-test). *p < 0.05, **p < 0.01, ***p < 0.001, ns, not significant.” appear below.

Resistant extracellular vesicles (EVs) induce the upregulation of genes associated with acquired drug resistance and increase the sensitive cells’ survivability. The quantification of several genes by quantitative polymerase chain reaction (qPCR) of (A) sensitive MCF-7 exposed to tamoxifen-resistant (TAM-R) and doxorubicin-resistant (DOX-R) EVs. (B) The gene expression level of sensitive MDA-MB-231 cells exposed to TAM-R and DOX-R. (C) The apoptotic rate by annexin V/propidium iodide labeling in sensitive MCF-7 and sensitive MDA-MB-231 previously exposed to resistant EVs and treated with TAM and DOX. (D) Representative images and the clonogenic surviving fraction of MCF-7 cells previously exposed to TAM-R and (E) DOX-R EVs treated with the respective drug. (F) Representative images and the clonogenic surviving fraction of MDA-MB-231 cells previously exposed to TAM-R and (G) DOX-R EVs treated with the respective drug. Values are displayed as the mean ± standard deviation from three independent experiments. The asterisks indicate a significant difference between TAM-R EVs or DOX-R EVs exposure compared to sensitive EV effects (unpaired t-test). *p < 0.05, **p < 0.01, ***p < 0.001, ns, not significant..

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

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